SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4zq0 14-3-3 PROTEIN
(Giardia
intestinalis) 		4 / 4 ASP A 104
LEU A 109
LEU A 106
LEU A 108
 None
 1.41A 1u18A-4zq0A:
undetectable		 1u18A-4zq0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4zq0 14-3-3 PROTEIN
(Giardia
intestinalis) 		4 / 5 ALA A 150
ALA A 138
TYR A 134
GLN A 110
 None
 1.09A 1xl6A-4zq0A:
2.5
1xl6B-4zq0A:
3.0		 1xl6A-4zq0A:
20.39
1xl6B-4zq0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4zq0 14-3-3 PROTEIN
(Giardia
intestinalis) 		4 / 5 ARG A  31
ASP A 104
ILE A 101
GLU A  28
 None
 1.22A 2xrzA-4zq0A:
undetectable
2xrzB-4zq0A:
1.5		 2xrzA-4zq0A:
17.93
2xrzB-4zq0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4zq0 14-3-3 PROTEIN
(Giardia
intestinalis) 		5 / 11 ARG A  60
LEU A  98
LEU A 106
GLY A 131
ASP A 132
 None
 1.36A 3sfuC-4zq0A:
undetectable		 3sfuC-4zq0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4zq0 14-3-3 PROTEIN
(Giardia
intestinalis) 		4 / 6 ARG A  45
ASP A 121
HIS A 171
ILE A 173
 None
 1.04A 5a06A-4zq0A:
undetectable		 5a06A-4zq0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4zq0 14-3-3 PROTEIN
(Giardia
intestinalis) 		5 / 10 LEU A 198
ALA A 202
LEU A 175
LEU A 177
LEU A 232
 None
 1.40A 5hyrA-4zq0A:
undetectable		 5hyrA-4zq0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4zq0 14-3-3 PROTEIN
(Giardia
intestinalis) 		4 / 6 TYR A 127
VAL A 124
ILE A 163
GLU A 162
 None
 0.74A 5z3jA-4zq0A:
undetectable		 5z3jA-4zq0A:
21.99