SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 6 PHE A  75
PHE A  64
GLU A  55
LEU A  54
 None
 0.94A 1hk1A-4zq8A:
undetectable		 1hk1A-4zq8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 SER A 161
PRO A 158
ALA A 132
ALA A 103
 None
 1.03A 1k5qA-4zq8A:
undetectable
1k5qB-4zq8A:
undetectable		 1k5qA-4zq8A:
20.05
1k5qB-4zq8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		3 / 3 ARG A 323
GLY A  87
PRO A  86
 None
 0.58A 2hreD-4zq8A:
undetectable		 2hreD-4zq8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		5 / 12 ASN A 276
ASP A 260
GLN A 347
GLY A  29
ASN A 259
 None
 1.06A 3eeyB-4zq8A:
undetectable		 3eeyB-4zq8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		5 / 12 ILE A  50
GLY A  78
ARG A  79
ALA A  42
ALA A  73
 None
 1.10A 3jb1A-4zq8A:
undetectable		 3jb1A-4zq8A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 5 LEU A 238
SER A 318
LEU A 234
PRO A 235
 None
 1.19A 3onnA-4zq8A:
undetectable		 3onnA-4zq8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 TYR A 346
ARG A 214
HIS A 274
HIS A 339
 None
 1.05A 3zodA-4zq8A:
undetectable		 3zodA-4zq8A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 8 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.46A 4tzcB-4zq8A:
undetectable
4tzcD-4zq8A:
undetectable		 4tzcB-4zq8A:
16.29
4tzcD-4zq8A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.41A 4tzuB-4zq8A:
undetectable
4tzuC-4zq8A:
undetectable		 4tzuB-4zq8A:
17.33
4tzuC-4zq8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.36A 4tzuB-4zq8A:
undetectable
4tzuC-4zq8A:
undetectable		 4tzuB-4zq8A:
17.33
4tzuC-4zq8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		6 / 9 ARG A 214
ASN A 259
SER A 263
ARG A 266
GLU A 267
TYR A 346
 None
 0.68A 5dz2A-4zq8A:
31.6		 5dz2A-4zq8A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		6 / 9 ARG A 214
ASN A 259
SER A 263
GLU A 267
ARG A 345
TYR A 346
 None
 1.06A 5dz2A-4zq8A:
31.6		 5dz2A-4zq8A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		6 / 9 ARG A 214
ASN A 259
SER A 263
ARG A 266
GLU A 267
TYR A 346
 None
 0.85A 5dz2B-4zq8A:
31.6		 5dz2B-4zq8A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		5 / 9 ASN A 259
SER A 263
GLU A 267
ARG A 345
TYR A 346
 None
 0.99A 5dz2B-4zq8A:
31.6		 5dz2B-4zq8A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		5 / 9 ASN A 259
SER A 263
GLU A 267
ARG A 345
TYR A 346
 None
 0.93A 5ermB-4zq8A:
10.4		 5ermB-4zq8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.37A 5yizG-4zq8A:
undetectable
5yizY-4zq8A:
undetectable		 5yizG-4zq8A:
13.89
5yizY-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.43A 5yizk-4zq8A:
undetectable
5yizt-4zq8A:
undetectable		 5yizk-4zq8A:
13.89
5yizt-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.40A 5yizk-4zq8A:
undetectable
5yizt-4zq8A:
undetectable		 5yizk-4zq8A:
13.89
5yizt-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.41A 5yizG-4zq8A:
undetectable
5yizY-4zq8A:
undetectable		 5yizG-4zq8A:
13.89
5yizY-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.40A 5yj0G-4zq8A:
undetectable
5yj0Y-4zq8A:
undetectable		 5yj0G-4zq8A:
13.89
5yj0Y-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.42A 5yj0k-4zq8A:
undetectable
5yj0t-4zq8A:
undetectable		 5yj0k-4zq8A:
13.89
5yj0t-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.39A 5yj0k-4zq8A:
undetectable
5yj0t-4zq8A:
undetectable		 5yj0k-4zq8A:
13.89
5yj0t-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.40A 5yj0G-4zq8A:
undetectable
5yj0Y-4zq8A:
undetectable		 5yj0G-4zq8A:
13.89
5yj0Y-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 8 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.37A 5yj1G-4zq8A:
undetectable
5yj1Y-4zq8A:
undetectable		 5yj1G-4zq8A:
16.30
5yj1Y-4zq8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.46A 5yj1k-4zq8A:
undetectable
5yj1t-4zq8A:
undetectable		 5yj1k-4zq8A:
16.30
5yj1t-4zq8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 8 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.32A 5yj1k-4zq8A:
undetectable
5yj1t-4zq8A:
undetectable		 5yj1k-4zq8A:
16.30
5yj1t-4zq8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 7 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.44A 5yj1G-4zq8A:
undetectable
5yj1Y-4zq8A:
undetectable		 5yj1G-4zq8A:
16.30
5yj1Y-4zq8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 6 ASP A 108
VAL A 107
GLU A 113
ALA A 199
 None
 1.12A 6djzB-4zq8A:
undetectable		 6djzB-4zq8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4zq8 ISOPRENOID SYNTHASE
(Streptomyces
lydicus) 		4 / 5 TYR A 346
GLU A 267
TYR A 192
HIS A 274
 None
 1.16A 6ep4A-4zq8A:
undetectable		 6ep4A-4zq8A:
10.70