SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 11 SER A  69
LEU A  77
ILE A  49
ALA A  48
LEU A  58
 None
 1.13A 1eqgB-4zqbA:
undetectable		 1eqgB-4zqbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 217
ALA A 240
GLY A 247
LEU A 251
LEU A 237
 None
 1.07A 1nr6A-4zqbA:
undetectable		 1nr6A-4zqbA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 10 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 0.99A 1pxxA-4zqbA:
undetectable		 1pxxA-4zqbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 0.98A 1pxxC-4zqbA:
undetectable		 1pxxC-4zqbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 11 ARG A 155
LEU A 154
ILE A 173
ARG A 157
GLY A 165
 None
 1.32A 2bxmA-4zqbA:
undetectable		 2bxmA-4zqbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 5 LEU A  58
PHE A  34
VAL A  45
ALA A  48
 None
 1.11A 2cizA-4zqbA:
undetectable		 2cizA-4zqbA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		3 / 3 ARG A 168
SER A 169
TYR A 313
 None
NAP  A 401 (-2.7A)
NAP  A 401 (-3.7A)
 0.76A 2q2hA-4zqbA:
undetectable
2q2hB-4zqbA:
undetectable		 2q2hA-4zqbA:
18.47
2q2hB-4zqbA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 148
GLY A 149
ASP A 252
ILE A 223
LEU A 111
 NAP  A 401 (-3.8A)
None
NAP  A 401 (-3.9A)
None
None
 1.11A 3eeoA-4zqbA:
4.5		 3eeoA-4zqbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.74A 3ln1A-4zqbA:
undetectable		 3ln1A-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.74A 3ln1B-4zqbA:
undetectable		 3ln1B-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.74A 3ln1C-4zqbA:
undetectable		 3ln1C-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.74A 3ln1D-4zqbA:
undetectable		 3ln1D-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A  22
LEU A  10
LEU A  96
LEU A  91
ALA A 279
 None
None
None
None
NAP  A 401 (-4.0A)
 1.16A 3vw7A-4zqbA:
undetectable		 3vw7A-4zqbA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.06A 4coxA-4zqbA:
undetectable		 4coxA-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.05A 4coxB-4zqbA:
undetectable		 4coxB-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.06A 4coxD-4zqbA:
undetectable		 4coxD-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.08A 4otyA-4zqbA:
undetectable		 4otyA-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.08A 4otyB-4zqbA:
undetectable		 4otyB-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.05A 4rrwC-4zqbA:
undetectable		 4rrwC-4zqbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.03A 4rrwD-4zqbA:
undetectable		 4rrwD-4zqbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.05A 4rrzC-4zqbA:
undetectable		 4rrzC-4zqbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.03A 4rrzD-4zqbA:
undetectable		 4rrzD-4zqbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 11 ILE A   4
LEU A  58
LEU A   6
GLY A  33
ALA A  51
 None
 1.24A 5fctA-4zqbA:
undetectable		 5fctA-4zqbA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 7 ILE A 289
HIS A  21
LEU A  22
ALA A  25
 None
 0.92A 5hrqE-4zqbA:
undetectable
5hrqF-4zqbA:
undetectable
5hrqJ-4zqbA:
undetectable		 5hrqE-4zqbA:
6.31
5hrqF-4zqbA:
7.97
5hrqJ-4zqbA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 0.99A 5ikqA-4zqbA:
undetectable		 5ikqA-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 0.96A 5ikqB-4zqbA:
undetectable		 5ikqB-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
 None
 1.01A 5iktA-4zqbA:
undetectable		 5iktA-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.74A 5jw1A-4zqbA:
undetectable		 5jw1A-4zqbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.80A 5kirA-4zqbA:
undetectable		 5kirA-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 176
ALA A 180
GLY A 149
ALA A 150
LEU A 154
 None
 0.86A 5kirB-4zqbA:
undetectable		 5kirB-4zqbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		4 / 6 SER A 278
ARG A 228
ALA A 227
ALA A  72
 NAP  A 401 (-3.0A)
SO4  A 402 ( 2.8A)
None
NAP  A 401 ( 3.9A)
 1.18A 6ma6A-4zqbA:
undetectable		 6ma6A-4zqbA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4zqb NADP-DEPENDENT
DEHYDROGENASE
(Rhodobacter
sphaeroides) 		5 / 11 ILE A   4
LEU A  58
LEU A   6
GLY A  33
ALA A  51
 None
 1.28A 6r2eF-4zqbA:
undetectable		 6r2eF-4zqbA:
22.74