SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zqv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 ARG A 157
ILE A  50
GLY A 153
ALA A 154
 None
 0.81A 1wmqA-4zqvA:
undetectable		 1wmqA-4zqvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 ARG A 157
ILE A  50
GLY A 153
ALA A 154
 None
 0.81A 1wmqB-4zqvA:
undetectable		 1wmqB-4zqvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 ARG A 157
ILE A  50
GLY A 153
ALA A 154
 None
 0.80A 1wpuA-4zqvA:
undetectable		 1wpuA-4zqvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 ARG A 157
ILE A  50
GLY A 153
ALA A 154
 None
 0.81A 1wpuB-4zqvA:
undetectable		 1wpuB-4zqvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 ARG A 157
ILE A  50
GLY A 153
ALA A 154
 None
 0.80A 1wrqA-4zqvA:
undetectable		 1wrqA-4zqvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 ARG A 157
ILE A  50
GLY A 153
ALA A 154
 None
 0.79A 1wrqB-4zqvA:
undetectable		 1wrqB-4zqvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 PHE A  73
SER A  69
GLY A  26
ARG A  31
 None
 1.20A 2f7fA-4zqvA:
undetectable		 2f7fA-4zqvA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 5 LEU A 156
GLY A  51
ILE A 117
ILE A 119
 None
 0.74A 2q9rA-4zqvA:
undetectable		 2q9rA-4zqvA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 4 ARG A 133
GLY A 132
GLU A 125
SER A 138
 None
 1.00A 2xctS-4zqvA:
undetectable
2xctU-4zqvA:
undetectable		 2xctS-4zqvA:
13.29
2xctU-4zqvA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 5 SER A 138
ARG A 133
GLY A 132
GLU A 125
 None
 1.24A 3k9fA-4zqvA:
undetectable
3k9fB-4zqvA:
undetectable
3k9fC-4zqvA:
undetectable		 3k9fA-4zqvA:
17.71
3k9fB-4zqvA:
17.71
3k9fC-4zqvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 5 GLY A 134
ARG A 123
GLY A 132
GLU A 125
 None
 1.11A 4z2eB-4zqvA:
undetectable
4z2eC-4zqvA:
undetectable		 4z2eB-4zqvA:
18.00
4z2eC-4zqvA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		3 / 3 ASN A 107
SER A  11
ARG A  32
 None
 0.94A 5b2qA-4zqvA:
undetectable		 5b2qA-4zqvA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 SER A 138
ARG A 133
GLY A 132
GLU A 125
 None
 1.03A 5btaA-4zqvA:
undetectable
5btaB-4zqvA:
undetectable
5btaC-4zqvA:
undetectable		 5btaA-4zqvA:
18.55
5btaB-4zqvA:
20.61
5btaC-4zqvA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 SER A 138
ARG A 133
GLY A 132
GLU A 125
 None
 0.98A 5btcA-4zqvA:
undetectable
5btcC-4zqvA:
undetectable
5btcD-4zqvA:
undetectable		 5btcA-4zqvA:
18.55
5btcC-4zqvA:
18.55
5btcD-4zqvA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 SER A 138
ARG A 133
GLY A 132
GLU A 125
 None
 1.01A 5btcA-4zqvA:
undetectable
5btcB-4zqvA:
undetectable
5btcC-4zqvA:
undetectable		 5btcA-4zqvA:
18.55
5btcB-4zqvA:
20.61
5btcC-4zqvA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		3 / 3 ILE A 143
PRO A 144
ILE A 117
 None
 0.42A 5hw8F-4zqvA:
undetectable		 5hw8F-4zqvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 5 LEU A 156
LEU A  58
THR A 118
ARG A  29
 None
 1.09A 6ew0F-4zqvA:
undetectable		 6ew0F-4zqvA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4zqv CDII IMMUNITY
PROTEIN
(Yersinia
kristensenii) 		4 / 6 LEU A 156
LEU A  58
THR A 118
ARG A  29
 None
 1.09A 6ew0G-4zqvA:
undetectable		 6ew0G-4zqvA:
18.42