SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 345
HIS A 326
ASP A 323
HIS A 349
HIS A 348
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
None
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.25A 1a4lA-4zr1A:
undetectable		 1a4lA-4zr1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 345
HIS A 326
ASP A 323
HIS A 349
HIS A 348
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
None
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.27A 1a4lC-4zr1A:
undetectable		 1a4lC-4zr1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 313
VAL A 233
TRP A 236
 None
 0.97A 1c4dA-4zr1A:
undetectable
1c4dB-4zr1A:
undetectable		 1c4dA-4zr1A:
5.26
1c4dB-4zr1A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 249
HIS A 345
HIS A 349
HIS A 272
 ZN  A 402 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.5A)
 0.96A 1e9yB-4zr1A:
undetectable		 1e9yB-4zr1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 8 PHE A 357
HIS A 272
HIS A 271
HIS A 268
HIS A 348
 None
ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
 1.49A 1ei6D-4zr1A:
undetectable		 1ei6D-4zr1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.70A 1rjoA-4zr1A:
undetectable		 1rjoA-4zr1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.65A 1rkyA-4zr1A:
undetectable		 1rkyA-4zr1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.70A 1w2zB-4zr1A:
undetectable		 1w2zB-4zr1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.72A 1w2zC-4zr1A:
undetectable		 1w2zC-4zr1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.69A 1w2zD-4zr1A:
undetectable		 1w2zD-4zr1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.73A 2oqeA-4zr1A:
undetectable		 2oqeA-4zr1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.72A 2oqeC-4zr1A:
undetectable		 2oqeC-4zr1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.68A 2w0qA-4zr1A:
undetectable		 2w0qA-4zr1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 349
HIS A 345
HIS A 348
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.69A 2w0qA-4zr1A:
undetectable		 2w0qA-4zr1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.70A 2w0qB-4zr1A:
undetectable		 2w0qB-4zr1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 244
HIS A 249
HIS A 268
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
 0.82A 2wkoA-4zr1A:
undetectable		 2wkoA-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 272
HIS A 271
HIS A 268
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 0.85A 2wkoA-4zr1A:
undetectable		 2wkoA-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 326
HIS A 330
HIS A 345
HIS A 271
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.4A)
 0.83A 2wkoA-4zr1A:
undetectable		 2wkoA-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 345
HIS A 330
HIS A 349
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.98A 2wkoA-4zr1A:
undetectable		 2wkoA-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 349
HIS A 348
HIS A 345
HIS A 272
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
 0.99A 2wkoA-4zr1A:
undetectable		 2wkoA-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 244
HIS A 249
HIS A 268
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
 0.86A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 272
HIS A 271
HIS A 268
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 0.90A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 326
HIS A 330
HIS A 345
HIS A 271
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.4A)
 0.89A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 345
HIS A 330
HIS A 349
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 0.99A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 348
HIS A 345
VAL A 359
HIS A 244
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
None
ZN  A 402 (-3.5A)
 0.97A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 349
HIS A 348
HIS A 345
HIS A 272
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
 1.04A 2wkoF-4zr1A:
undetectable		 2wkoF-4zr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.78A 2zxwA-4zr1A:
2.6		 2zxwA-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.74A 3abkA-4zr1A:
2.7		 3abkA-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.73A 3abkN-4zr1A:
2.8		 3abkN-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.73A 3ag2A-4zr1A:
1.6		 3ag2A-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.75A 3ag3N-4zr1A:
undetectable		 3ag3N-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.75A 3asoA-4zr1A:
2.3		 3asoA-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 173
HIS A 348
HIS A 349
HIS A 345
VAL A 359
 None
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
None
 1.17A 3bl1A-4zr1A:
undetectable		 3bl1A-4zr1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 380
TYR A 273
ASP A 251
GLN A 354
 None
 1.45A 3dh0A-4zr1A:
undetectable		 3dh0A-4zr1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.72A 3hiiB-4zr1A:
undetectable		 3hiiB-4zr1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 247
HIS A 268
HIS A 272
HIS A 348
LEU A 243
 None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
None
 1.02A 3hy7A-4zr1A:
undetectable		 3hy7A-4zr1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 247
HIS A 268
HIS A 272
HIS A 348
LEU A 243
 None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
None
 1.11A 3hy7B-4zr1A:
undetectable		 3hy7B-4zr1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 277
HIS A 348
LEU A 154
LEU A 274
 None
ZN  A 402 (-3.3A)
None
None
 1.04A 3lm8B-4zr1A:
undetectable
3lm8D-4zr1A:
undetectable		 3lm8B-4zr1A:
20.13
3lm8D-4zr1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 0.87A 3mihA-4zr1A:
undetectable		 3mihA-4zr1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 244
HIS A 348
HIS A 268
ASP A 251
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
None
 1.17A 3nvcA-4zr1A:
undetectable		 3nvcA-4zr1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 272
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 0.79A 3s39A-4zr1A:
undetectable		 3s39A-4zr1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 272
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 0.79A 3s3cA-4zr1A:
2.8		 3s3cA-4zr1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.80A 3s3cA-4zr1A:
2.8		 3s3cA-4zr1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 272
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 0.76A 3s3dA-4zr1A:
undetectable		 3s3dA-4zr1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 264
GLY A 269
ASP A 251
HIS A 249
HIS A 348
 None
None
None
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 1.17A 4bz6C-4zr1A:
undetectable		 4bz6C-4zr1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 344
HIS A 268
HIS A 249
HIS A 272
HIS A 345
 None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
 1.28A 4c1dB-4zr1A:
undetectable		 4c1dB-4zr1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 272
HIS A 173
HIS A 268
HIS A 249
 ZN  A 402 (-3.5A)
None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
 1.17A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.10A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 349
HIS A 345
HIS A 272
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
 1.10A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 244
HIS A 249
HIS A 349
HIS A 348
HIS A 272
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.25A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 1.39A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.25A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.28A 4ef3A-4zr1A:
undetectable		 4ef3A-4zr1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 249
HIS A 345
HIS A 349
HIS A 272
 ZN  A 402 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.5A)
 0.96A 4h9mA-4zr1A:
undetectable		 4h9mA-4zr1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 268
HIS A 244
HIS A 345
HIS A 326
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
 0.92A 4p6sA-4zr1A:
undetectable		 4p6sA-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 7 HIS A 345
HIS A 326
HIS A 268
HIS A 244
VAL A 359
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
 1.05A 4p6sA-4zr1A:
undetectable		 4p6sA-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 268
HIS A 244
HIS A 345
HIS A 326
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
 0.90A 4p6sB-4zr1A:
undetectable		 4p6sB-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 7 HIS A 345
HIS A 326
HIS A 268
HIS A 244
VAL A 359
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
 1.05A 4p6sB-4zr1A:
undetectable		 4p6sB-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 243
TYR A 322
TYR A 319
PHE A 288
LEU A 291
 None
None
None
TRD  A 409 (-4.7A)
TRD  A 409 ( 4.4A)
 1.33A 5cymA-4zr1A:
undetectable		 5cymA-4zr1A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 243
TYR A 322
TYR A 319
PHE A 288
LEU A 291
 None
None
None
TRD  A 409 (-4.7A)
TRD  A 409 ( 4.4A)
 1.32A 5cyqA-4zr1A:
undetectable		 5cyqA-4zr1A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 281
CYH A 325
HIS A 331
LEU A 329
 None
BOG  A 405 ( 4.9A)
None
None
 1.48A 5hrqD-4zr1A:
undetectable
5hrqG-4zr1A:
undetectable
5hrqH-4zr1A:
undetectable		 5hrqD-4zr1A:
9.23
5hrqG-4zr1A:
5.04
5hrqH-4zr1A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 7 HIS A 345
HIS A 326
HIS A 268
HIS A 244
VAL A 359
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
 1.04A 5i3aA-4zr1A:
undetectable		 5i3aA-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 268
HIS A 244
HIS A 345
HIS A 326
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
 0.91A 5i3aB-4zr1A:
undetectable		 5i3aB-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 7 HIS A 345
HIS A 326
HIS A 268
HIS A 244
VAL A 359
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
 1.02A 5i3aB-4zr1A:
undetectable		 5i3aB-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 7 HIS A 345
HIS A 326
HIS A 268
HIS A 244
VAL A 359
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
 1.07A 5i3bA-4zr1A:
undetectable		 5i3bA-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 345
HIS A 326
HIS A 244
VAL A 359
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.5A)
None
 1.04A 5i3bB-4zr1A:
undetectable		 5i3bB-4zr1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 149
ASP A 118
ARG A 174
GLN A 171
 None
 1.24A 5l6eA-4zr1A:
undetectable		 5l6eA-4zr1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 7 HIS A 326
HIS A 268
HIS A 244
LEU A 243
VAL A 359
 ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
None
 1.40A 5m8rA-4zr1A:
undetectable		 5m8rA-4zr1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 8 HIS A 326
HIS A 268
HIS A 244
LEU A 243
VAL A 359
 ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
None
 1.41A 5m8rB-4zr1A:
undetectable		 5m8rB-4zr1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 326
HIS A 349
HIS A 272
GLY A 269
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.5A)
None
 0.91A 5m8rC-4zr1A:
undetectable		 5m8rC-4zr1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 1.39A 5mejA-4zr1A:
undetectable		 5mejA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.15A 5mejA-4zr1A:
undetectable		 5mejA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.18A 5mejA-4zr1A:
undetectable		 5mejA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 271
HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.29A 5mejA-4zr1A:
undetectable		 5mejA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 1.38A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.14A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.18A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 271
HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.29A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.14A 5mhuA-4zr1A:
undetectable		 5mhuA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.18A 5mhuA-4zr1A:
undetectable		 5mhuA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 271
HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.30A 5mhuA-4zr1A:
undetectable		 5mhuA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.15A 5mhvA-4zr1A:
undetectable		 5mhvA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.19A 5mhvA-4zr1A:
undetectable		 5mhvA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 271
HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.30A 5mhvA-4zr1A:
undetectable		 5mhvA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 0.99A 5mhwA-4zr1A:
undetectable		 5mhwA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.00A 5mhxA-4zr1A:
undetectable		 5mhxA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.00A 5mhyA-4zr1A:
undetectable		 5mhyA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.00A 5mhzA-4zr1A:
undetectable		 5mhzA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.00A 5mi1A-4zr1A:
undetectable		 5mi1A-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.00A 5mi2A-4zr1A:
undetectable		 5mi2A-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.01A 5miaA-4zr1A:
undetectable		 5miaA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 268
HIS A 244
HIS A 348
HIS A 272
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.23A 5miaA-4zr1A:
undetectable		 5miaA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.00A 5mibA-4zr1A:
undetectable		 5mibA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.01A 5micA-4zr1A:
undetectable		 5micA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 268
HIS A 244
HIS A 348
HIS A 272
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.23A 5micA-4zr1A:
undetectable		 5micA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.01A 5midA-4zr1A:
undetectable		 5midA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.01A 5mieA-4zr1A:
undetectable		 5mieA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 268
HIS A 244
HIS A 348
HIS A 272
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.23A 5migA-4zr1A:
undetectable		 5migA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 269
HIS A 173
ASP A 251
HIS A 244
 None
None
None
ZN  A 402 (-3.5A)
 1.07A 5nnwD-4zr1A:
undetectable		 5nnwD-4zr1A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 173
HIS A 272
HIS A 268
 None
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 0.76A 5oexA-4zr1A:
undetectable		 5oexA-4zr1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.74A 5waua-4zr1A:
undetectable		 5waua-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.73A 5x19A-4zr1A:
undetectable		 5x19A-4zr1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 249
HIS A 268
HIS A 244
HIS A 348
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.04A 5zrdB-4zr1A:
undetectable		 5zrdB-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 330
HIS A 345
HIS A 326
HIS A 271
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
 1.07A 5zrdB-4zr1A:
undetectable		 5zrdB-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 345
HIS A 326
HIS A 330
HIS A 349
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.01A 5zrdB-4zr1A:
undetectable		 5zrdB-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 349
HIS A 345
HIS A 330
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.4A)
 1.04A 5zrdB-4zr1A:
undetectable		 5zrdB-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 244
HIS A 348
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 1.14A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 249
HIS A 268
HIS A 244
HIS A 348
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.05A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 268
HIS A 244
HIS A 249
HIS A 272
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
 1.13A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 272
HIS A 268
HIS A 249
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 1.10A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 330
HIS A 326
HIS A 271
HIS A 349
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 401 (-3.2A)
 1.13A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 330
HIS A 345
HIS A 326
HIS A 271
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
 1.09A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 330
HIS A 349
HIS A 345
HIS A 326
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
 1.09A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 345
HIS A 326
HIS A 330
HIS A 349
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 0.99A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 349
HIS A 345
HIS A 330
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.4A)
 1.03A 5zrdC-4zr1A:
2.5		 5zrdC-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 244
HIS A 348
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 1.13A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 249
HIS A 268
HIS A 244
HIS A 348
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.04A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 268
HIS A 244
HIS A 249
HIS A 272
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
 1.14A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 272
HIS A 268
HIS A 249
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 1.08A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 330
HIS A 326
HIS A 271
HIS A 349
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 401 (-3.2A)
 1.10A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 330
HIS A 345
HIS A 326
HIS A 271
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
 1.09A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 330
HIS A 349
HIS A 345
HIS A 326
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
 1.10A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 345
HIS A 326
HIS A 330
HIS A 349
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 0.98A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 349
HIS A 345
HIS A 330
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.4A)
 1.01A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 150
ASP A 149
GLN A 157
VAL A 282
 None
 1.24A 6bzoF-4zr1A:
2.7		 6bzoF-4zr1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 243
TYR A 322
TYR A 319
PHE A 288
LEU A 291
 None
None
None
TRD  A 409 (-4.7A)
TRD  A 409 ( 4.4A)
 1.31A 6eliA-4zr1A:
undetectable		 6eliA-4zr1A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 272
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 0.74A 6giqa-4zr1A:
2.4		 6giqa-4zr1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.75A 6giqa-4zr1A:
2.4		 6giqa-4zr1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.76A 6nmpA-4zr1A:
2.5		 6nmpA-4zr1A:
20.12