SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 5 ARG A 111
SER A 381
ASN A 392
SER A 405
 None
 1.42A 1kiaB-4zr5A:
undetectable		 1kiaB-4zr5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 6 ARG A 111
SER A 381
ASN A 392
SER A 405
 None
 1.43A 1kiaC-4zr5A:
undetectable		 1kiaC-4zr5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 4 ASP A 651
HIS A 584
ARG A 718
GLU A 647
 None
ZN  A 801 ( 3.3A)
RDF  A 802 (-2.7A)
ZN  A 801 ( 2.2A)
 1.07A 1lqtA-4zr5A:
undetectable		 1lqtA-4zr5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 ASP A 632
PRO A 714
THR A 644
PHE A 717
GLY A 627
 None
 1.32A 1nw5A-4zr5A:
undetectable		 1nw5A-4zr5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 GLY A 654
GLY A 656
TYR A 659
LEU A  69
PRO A 563
 None
 1.10A 1p91B-4zr5A:
undetectable		 1p91B-4zr5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 10 ASP A 220
ARG A 293
LEU A 299
ILE A 308
ILE A 201
 None
 1.17A 1q6iB-4zr5A:
undetectable		 1q6iB-4zr5A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 6 PHE A 690
PHE A 687
ASN A 652
GLN A 724
 None
 1.50A 1t9uA-4zr5A:
2.8		 1t9uA-4zr5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		3 / 3 ILE A 511
ASP A 378
PHE A 375
 None
 0.63A 1uwjB-4zr5A:
undetectable		 1uwjB-4zr5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.79A 1v7zA-4zr5A:
undetectable		 1v7zA-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.80A 1v7zB-4zr5A:
undetectable		 1v7zB-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.80A 1v7zC-4zr5A:
undetectable		 1v7zC-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.81A 1v7zD-4zr5A:
undetectable		 1v7zD-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.82A 1v7zE-4zr5A:
undetectable		 1v7zE-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.81A 1v7zF-4zr5A:
undetectable		 1v7zF-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 GLY A 654
ILE A 578
GLY A 577
GLY A 576
ILE A 447
 None
 0.74A 2avvA-4zr5A:
undetectable		 2avvA-4zr5A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 ALA A 544
HIS A 584
GLU A 585
HIS A 588
GLU A 647
 RDF  A 802 (-4.1A)
ZN  A 801 ( 3.3A)
RDF  A 802 (-2.7A)
ZN  A 801 ( 3.2A)
ZN  A 801 ( 2.2A)
 0.36A 2c6nA-4zr5A:
4.3		 2c6nA-4zr5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 7 GLY A 594
ASP A 591
ASN A 593
ASP A 651
 None
 0.84A 2g72B-4zr5A:
undetectable		 2g72B-4zr5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 LEU A 314
PHE A 321
LEU A 359
ILE A 219
LEU A 370
 None
 1.25A 2po7B-4zr5A:
undetectable		 2po7B-4zr5A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 7 LEU A 688
LEU A 675
MET A  73
GLN A 692
 None
 1.07A 2qqcG-4zr5A:
undetectable
2qqcJ-4zr5A:
undetectable		 2qqcG-4zr5A:
5.24
2qqcJ-4zr5A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 7 LEU A 688
LEU A 675
MET A  73
GLN A 692
 None
 1.06A 2qqcI-4zr5A:
undetectable
2qqcL-4zr5A:
undetectable		 2qqcI-4zr5A:
5.24
2qqcL-4zr5A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 9 LEU A 200
ILE A 358
ALA A 286
GLY A 225
LEU A 224
 None
 1.18A 2v0mB-4zr5A:
undetectable		 2v0mB-4zr5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 VAL A 439
SER A 436
PHE A 565
ASN A 571
TYR A 665
 None
 1.38A 2y04B-4zr5A:
undetectable		 2y04B-4zr5A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 6 SER A 187
PRO A 162
GLY A 166
TRP A 174
 None
 1.42A 2y7pA-4zr5A:
undetectable		 2y7pA-4zr5A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.79A 3a6jA-4zr5A:
undetectable		 3a6jA-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 7 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.77A 3a6jB-4zr5A:
undetectable		 3a6jB-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.77A 3a6jC-4zr5A:
undetectable		 3a6jC-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.81A 3a6jE-4zr5A:
undetectable		 3a6jE-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.76A 3a6jF-4zr5A:
undetectable		 3a6jF-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 ILE A 447
GLY A 583
ALA A 544
ALA A 650
ILE A 578
 None
None
RDF  A 802 (-4.1A)
ZN  A 801 ( 4.9A)
None
 0.96A 3jayA-4zr5A:
undetectable		 3jayA-4zr5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 PHE A 203
ILE A 219
PHE A 326
VAL A 344
 None
 0.74A 3me6B-4zr5A:
undetectable		 3me6B-4zr5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 11 LEU A 314
GLU A 185
PHE A 321
LEU A 200
ILE A 188
 None
 1.46A 3o94B-4zr5A:
undetectable		 3o94B-4zr5A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 11 LEU A 314
GLU A 185
PHE A 321
LEU A 200
ILE A 188
 None
 1.47A 3o94C-4zr5A:
undetectable		 3o94C-4zr5A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 11 LEU A 314
GLU A 185
PHE A 321
LEU A 200
ILE A 188
 None
 1.46A 3o94D-4zr5A:
undetectable		 3o94D-4zr5A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 11 ILE A 707
ALA A 634
GLY A 636
GLY A 236
TYR A 238
 None
 1.23A 4e47C-4zr5A:
undetectable		 4e47C-4zr5A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 5 THR A 171
GLY A 166
VAL A 164
PRO A 162
 None
 1.17A 4grkA-4zr5A:
undetectable		 4grkA-4zr5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 4 VAL A 344
THR A 304
GLU A 342
GLU A 341
 None
 1.35A 4l78A-4zr5A:
undetectable		 4l78A-4zr5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 TYR A 626
PHE A 629
ILE A 719
ILE A 655
PRO A  79
 None
 1.30A 4nnrA-4zr5A:
undetectable
4nnrB-4zr5A:
undetectable		 4nnrA-4zr5A:
11.94
4nnrB-4zr5A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 PRO A  98
ILE A  97
TYR A 698
ASN A  72
ASP A 108
 None
None
None
None
RDF  A 802 (-3.7A)
 1.35A 4xe0A-4zr5A:
3.1		 4xe0A-4zr5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 10 ASP A 208
TYR A 347
TYR A 300
GLY A 601
PHE A 597
 None
 1.39A 4xpbA-4zr5A:
undetectable		 4xpbA-4zr5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 11 ILE A 707
ALA A 634
GLY A 636
GLY A 236
TYR A 238
 None
 1.18A 5ayfA-4zr5A:
undetectable		 5ayfA-4zr5A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 ILE A 336
LYS A 525
VAL A 334
GLN A 522
 None
 1.13A 5dqyA-4zr5A:
undetectable		 5dqyA-4zr5A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 ASP A 632
PRO A 714
THR A 644
PHE A 717
GLY A 627
 None
 1.38A 5hfjC-4zr5A:
undetectable		 5hfjC-4zr5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 ASP A 632
PRO A 714
THR A 644
PHE A 717
GLY A 627
 None
 1.40A 5hfjH-4zr5A:
undetectable		 5hfjH-4zr5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 9 ILE A 219
ILE A 201
VAL A 344
THR A 327
ILE A 330
 None
 1.28A 5mvnB-4zr5A:
1.8		 5mvnB-4zr5A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 10 ILE A 219
ILE A 201
VAL A 344
THR A 327
ILE A 330
 None
 1.30A 5mvnD-4zr5A:
undetectable		 5mvnD-4zr5A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 6 ARG A 550
THR A 207
ASP A 208
ASP A 602
 None
 1.09A 5tdzA-4zr5A:
undetectable		 5tdzA-4zr5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 7 ALA A 397
GLY A 400
TYR A 399
TYR A 702
 None
 0.98A 5uxdA-4zr5A:
1.8		 5uxdA-4zr5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 5 LEU A 367
LYS A 361
LEU A 279
GLU A 282
 None
 1.06A 5weaA-4zr5A:
undetectable		 5weaA-4zr5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 GLY A 579
SER A 566
LEU A 573
GLY A 576
GLY A 577
 None
 0.99A 5wyqB-4zr5A:
undetectable		 5wyqB-4zr5A:
16.16