SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 5 GLY A 146
LEU A 151
THR A 150
VAL A 189
 None
 0.90A 1ekjF-4zr8A:
undetectable
1ekjG-4zr8A:
undetectable		 1ekjF-4zr8A:
20.22
1ekjG-4zr8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 6 LEU A 292
THR A  21
ALA A 326
LEU A 328
 None
 0.91A 1etb2-4zr8A:
undetectable		 1etb2-4zr8A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 263
ALA A 264
ASP A 265
ILE A 230
THR A 249
 None
 0.90A 1k6cB-4zr8A:
undetectable		 1k6cB-4zr8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		3 / 3 ARG A  31
VAL A 336
TRP A 335
 None
 1.20A 1qwcA-4zr8A:
undetectable		 1qwcA-4zr8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 10 GLY A 263
ALA A 264
ASP A 265
ILE A 230
THR A 249
 None
 0.80A 1t7iA-4zr8A:
undetectable		 1t7iA-4zr8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 11 GLY A 263
ALA A 264
ASP A 265
ILE A 230
THR A 249
 None
 0.80A 1t7jA-4zr8A:
undetectable		 1t7jA-4zr8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		3 / 3 ARG A  31
VAL A 336
TRP A 335
 None
 1.26A 1vagA-4zr8A:
undetectable		 1vagA-4zr8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 11 GLU A 320
GLY A 323
PRO A  22
SER A 352
TYR A 355
 None
 1.46A 2h21C-4zr8A:
undetectable		 2h21C-4zr8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		3 / 3 ARG A  27
VAL A 124
THR A  80
 EDO  A 403 ( 3.8A)
None
None
 0.82A 2nmzA-4zr8A:
undetectable		 2nmzA-4zr8A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 11 GLY A 263
ALA A 264
ASP A 265
ILE A 204
PRO A 148
 None
 0.96A 2nnpA-4zr8A:
undetectable		 2nnpA-4zr8A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 6 THR A 249
ASP A 270
THR A 272
ASP A 293
 None
 1.12A 2okcB-4zr8A:
undetectable		 2okcB-4zr8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 LEU A  10
ARG A  11
ILE A 243
ALA A 203
ASP A   7
 None
 1.13A 3axtA-4zr8A:
2.4		 3axtA-4zr8A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		3 / 3 LEU A  14
GLU A 237
ILE A 243
 None
 0.49A 3czhA-4zr8A:
undetectable		 3czhA-4zr8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 263
ALA A 264
ASP A 265
ILE A 230
THR A 249
 None
 0.81A 3el5B-4zr8A:
undetectable		 3el5B-4zr8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 10 GLY A 263
ALA A 264
ASP A 265
ILE A 230
THR A 249
 None
 0.89A 3el9B-4zr8A:
undetectable		 3el9B-4zr8A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 10 GLY A 263
ALA A 264
ASP A 265
ILE A 246
ILE A 230
 None
 1.06A 3el9B-4zr8A:
undetectable		 3el9B-4zr8A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 6 VAL A 247
LEU A 328
MET A  26
ILE A 206
 None
 0.96A 3gcsA-4zr8A:
undetectable		 3gcsA-4zr8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 263
ALA A 264
ASP A 265
ILE A 204
PRO A 148
 None
 0.92A 3oxcA-4zr8A:
undetectable		 3oxcA-4zr8A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 7 GLY A 263
ALA A 264
ASP A 265
ILE A 230
 None
 0.74A 3t3cA-4zr8A:
undetectable		 3t3cA-4zr8A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 7 ASP A 208
GLY A 268
SER A 147
THR A 150
 None
 0.72A 4ac9C-4zr8A:
2.8		 4ac9C-4zr8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 LEU A  13
LEU A  10
LEU A   4
ILE A 246
GLN A 205
 None
 1.12A 4f4dA-4zr8A:
undetectable		 4f4dA-4zr8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 SER A 188
LEU A 115
PRO A 113
GLY A  88
LEU A  87
 None
 1.25A 4j7xB-4zr8A:
3.9		 4j7xB-4zr8A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 193
VAL A 189
MET A 227
ILE A 230
ALA A 264
 None
 1.07A 4ltwA-4zr8A:
undetectable		 4ltwA-4zr8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 10 GLY A 263
ALA A 264
ASP A 265
ILE A 230
THR A 249
 None
 0.81A 4njtB-4zr8A:
undetectable		 4njtB-4zr8A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 9 GLY A 263
ALA A 264
ASP A 265
ILE A 230
THR A 249
 None
 0.83A 4njtD-4zr8A:
undetectable		 4njtD-4zr8A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 MET A 227
ILE A 206
THR A 153
LEU A 178
LEU A 182
 None
 1.26A 4qynB-4zr8A:
undetectable		 4qynB-4zr8A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 256
GLY A 290
GLY A 329
LEU A 292
LEU A 275
 None
 1.20A 4x61A-4zr8A:
10.8		 4x61A-4zr8A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 7 LEU A 292
THR A  21
ALA A 326
LEU A 328
 None
 0.96A 5bojB-4zr8A:
undetectable		 5bojB-4zr8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 4 ALA A 117
PRO A  82
LEU A 181
HIS A 184
 None
None
None
MG  A 401 ( 4.8A)
 1.49A 5eskA-4zr8A:
undetectable		 5eskA-4zr8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		3 / 3 ARG A  31
VAL A 336
TRP A 335
 None
 1.17A 5fvoA-4zr8A:
undetectable		 5fvoA-4zr8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 7 GLY A 251
TRP A 210
TYR A 154
ASP A 208
 None
 1.29A 5vlmG-4zr8A:
undetectable		 5vlmG-4zr8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 10 ILE A 246
GLN A 289
GLN A 205
ALA A 201
ILE A  73
 None
None
None
None
CL  A 404 ( 4.4A)
 1.39A 5zovA-4zr8A:
0.0		 5zovA-4zr8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		5 / 12 ILE A 246
GLN A 289
GLN A 205
ALA A 201
ILE A  73
 None
None
None
None
CL  A 404 ( 4.4A)
 1.46A 5zovB-4zr8A:
undetectable		 5zovB-4zr8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		3 / 3 GLN A 205
TRP A  24
VAL A 325
 None
 1.07A 6auuA-4zr8A:
undetectable		 6auuA-4zr8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4zr8 UROPORPHYRINOGEN
DECARBOXYLASE
(Acinetobacter
baumannii) 		4 / 8 LEU A 356
GLU A 320
THR A  21
ASN A 318
 None
 1.22A 6c71B-4zr8A:
undetectable		 6c71B-4zr8A:
13.46