SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 10 PHE A  71
VAL A  16
VAL A  70
ILE A 236
TYR A 170
 None
None
None
None
NAD  A 401 (-4.7A)
 1.47A 13gsA-4zrmA:
undetectable		 13gsA-4zrmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 9 PHE A  71
VAL A  16
VAL A  70
ILE A 236
TYR A 170
 None
None
None
None
NAD  A 401 (-4.7A)
 1.47A 13gsB-4zrmA:
undetectable		 13gsB-4zrmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 12 MET A  58
LEU A 100
PHE A 112
LEU A   4
VAL A  17
 None
 1.43A 1hrkB-4zrmA:
3.2		 1hrkB-4zrmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 9 GLY A 119
GLU A 124
GLY A 123
GLY A 269
ASP A 270
 None
 1.13A 1mxdA-4zrmA:
undetectable		 1mxdA-4zrmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 11 GLY A 119
GLU A 124
GLY A 123
GLY A 269
ASP A 270
 None
 1.13A 1mxgA-4zrmA:
2.5		 1mxgA-4zrmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 12 LEU A  20
GLY A   7
ILE A  12
TYR A 170
ILE A 236
 None
NAD  A 401 (-3.5A)
NAD  A 401 (-4.0A)
NAD  A 401 (-4.7A)
None
 0.98A 1pbkA-4zrmA:
undetectable		 1pbkA-4zrmA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		4 / 7 GLU A 135
LYS A 280
ASN A 235
PRO A 132
 None
 1.36A 2ejgB-4zrmA:
undetectable		 2ejgB-4zrmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 11 GLY A 119
ILE A 236
ALA A 221
VAL A 173
ILE A  12
 None
None
None
NAD  A 401 (-3.8A)
NAD  A 401 (-4.0A)
 1.14A 2nnhA-4zrmA:
undetectable		 2nnhA-4zrmA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 12 SER A 104
LEU A   4
VAL A  30
LEU A 154
LEU A 163
 None
 1.37A 2prgB-4zrmA:
undetectable		 2prgB-4zrmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		3 / 3 ARG A 220
ASN A 172
THR A 238
 None
None
GOL  A 402 ( 4.1A)
 0.89A 2q63A-4zrmA:
undetectable		 2q63A-4zrmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		4 / 8 VAL A 219
VAL A   5
HIS A  15
VAL A 215
 None
 1.01A 3fhxB-4zrmA:
2.7		 3fhxB-4zrmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		4 / 5 ILE A 121
PRO A 139
LYS A 147
GLY A 144
 None
None
NAD  A 401 (-2.8A)
None
 0.96A 3tkdB-4zrmA:
undetectable		 3tkdB-4zrmA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		4 / 5 ILE A 121
PRO A 139
LYS A 147
GLY A 144
 None
None
NAD  A 401 (-2.8A)
None
 0.94A 3tkdA-4zrmA:
undetectable		 3tkdA-4zrmA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 12 MET A  58
LEU A 100
PHE A 112
LEU A   4
VAL A  17
 None
 1.42A 3w1wB-4zrmA:
2.0		 3w1wB-4zrmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		4 / 5 HIS A 201
VAL A 200
GLU A 199
LYS A 264
 None
 1.47A 4p6vB-4zrmA:
undetectable
4p6vE-4zrmA:
undetectable		 4p6vB-4zrmA:
20.19
4p6vE-4zrmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		5 / 12 GLY A 162
LYS A 164
GLU A 102
LEU A 101
LEU A 154
 None
 1.24A 5nwvA-4zrmA:
undetectable		 5nwvA-4zrmA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4zrm UDP-GLUCOSE
4-EPIMERASE
(Thermotoga
maritima) 		4 / 8 GLY A 237
ARG A 220
VAL A 213
ASP A 217
 None
 1.06A 5vlmA-4zrmA:
1.0		 5vlmA-4zrmA:
19.49