SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4zro 3C-LIKE PROTEINASE
(Alphacoronavirus
1) 		3 / 3 ASN A  25
LEU A  27
HIS A  41
 None
 0.72A 2q6fB-4zroA:
38.6		 2q6fB-4zroA:
42.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4zro 3C-LIKE PROTEINASE
(Alphacoronavirus
1) 		3 / 3 TYR A 125
TYR A 160
GLY A 137
 None
 0.63A 3eteB-4zroA:
undetectable
3eteD-4zroA:
undetectable
3eteF-4zroA:
undetectable		 3eteB-4zroA:
21.76
3eteD-4zroA:
21.76
3eteF-4zroA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4zro 3C-LIKE PROTEINASE
(Alphacoronavirus
1) 		4 / 5 PHE A 158
ILE A 113
ASN A  96
PHE A 111
 None
 1.27A 3octA-4zroA:
undetectable		 3octA-4zroA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4zro 3C-LIKE PROTEINASE
(Alphacoronavirus
1) 		4 / 7 PHE A 238
VAL A 203
ILE A 265
SER A 282
 None
 0.99A 3pglA-4zroA:
undetectable		 3pglA-4zroA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4zro 3C-LIKE PROTEINASE
(Alphacoronavirus
1) 		4 / 5 HIS A 163
GLY A 173
TYR A 181
GLU A 179
 None
 1.42A 4ae1B-4zroA:
undetectable		 4ae1B-4zroA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EU8_B_010B6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4zro 3C-LIKE PROTEINASE
(Alphacoronavirus
1) 		4 / 5 ASN A  25
LEU A  27
THR A  47
CYH A 144
 None
 0.74A 5eu8A-4zroA:
43.1		 5eu8A-4zroA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4zro 3C-LIKE PROTEINASE
(Alphacoronavirus
1) 		3 / 3 GLY A 169
ASN A 168
ARG A 130
 None
 0.75A 5w7bD-4zroA:
undetectable		 5w7bD-4zroA:
12.59