SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zrq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.23A 1hrkB-4zrqA:
undetectable		 1hrkB-4zrqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zrq CD320 ANTIGEN
TRANSCOBALAMIN-2
(Homo
sapiens) 		3 / 3 TRP C  72
HIS A  56
LYS A  59
 None
 1.48A 1l7xA-4zrqC:
undetectable		 1l7xA-4zrqC:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4zrq CD320 ANTIGEN
TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 LEU A  94
HIS A 104
GLY A 106
ASP C  75
ASP C  79
 None
None
None
CA  C 202 (-3.2A)
CA  C 202 (-3.3A)
 1.02A 1zz1C-4zrqA:
undetectable		 1zz1C-4zrqA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.20A 2hrcA-4zrqA:
undetectable		 2hrcA-4zrqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.18A 2hrcB-4zrqA:
undetectable		 2hrcB-4zrqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 10 LEU A 250
ALA A 248
LEU A 245
MET A   2
LEU A 232
 None
 1.45A 2ocfA-4zrqA:
undetectable		 2ocfA-4zrqA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 11 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.30A 2po5B-4zrqA:
undetectable		 2po5B-4zrqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.27A 2qd4B-4zrqA:
undetectable		 2qd4B-4zrqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 5 LEU A 256
ARG A 253
ALA A 255
ILE A   5
 None
 1.01A 2qhfA-4zrqA:
undetectable		 2qhfA-4zrqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 5 LEU A 260
GLN A 266
THR A 228
HIS A 221
 None
 1.20A 2zj0B-4zrqA:
undetectable		 2zj0B-4zrqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.29A 3aqiB-4zrqA:
undetectable		 3aqiB-4zrqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 5 PRO A 229
SER A 227
LEU A 260
SER A 259
 None
CNC  A 501 (-3.2A)
None
None
 1.39A 3iluH-4zrqA:
undetectable		 3iluH-4zrqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 6 LEU A 162
GLU A 166
PRO A 167
ARG A 200
 None
 1.48A 3ltwA-4zrqA:
undetectable		 3ltwA-4zrqA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		3 / 3 HIS A 345
SER A 365
GLU A 353
 None
 0.86A 3s8pA-4zrqA:
undetectable		 3s8pA-4zrqA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 4 PRO A 229
LEU A 232
ILE A   5
ARG A 253
 None
 1.37A 3w1wA-4zrqA:
undetectable		 3w1wA-4zrqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 GLY A 142
GLY A 140
LEU A 183
SER A 135
ALA A  88
 None
None
None
CNC  A 501 ( 4.0A)
None
 1.09A 4qtuB-4zrqA:
undetectable		 4qtuB-4zrqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 9 LEU A 388
GLU A 219
ALA A 264
SER A 259
ALA A 258
 None
 1.40A 4wnuB-4zrqA:
undetectable		 4wnuB-4zrqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 10 LEU A 250
ALA A 248
LEU A 245
MET A   2
LEU A 232
 None
 1.41A 5dxeB-4zrqA:
undetectable		 5dxeB-4zrqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 8 PRO A 276
MET A  24
LEU A 298
LEU A 260
 None
 0.95A 5ieoA-4zrqA:
undetectable		 5ieoA-4zrqA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		3 / 3 LEU A 358
TYR A  62
SER A  83
 CNC  A 501 (-3.6A)
None
CNC  A 501 ( 4.3A)
 0.89A 5iktA-4zrqA:
0.7		 5iktA-4zrqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4zrq TRANSCOBALAMIN-2
CD320 ANTIGEN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TYR A 139
VAL A 110
LEU A 188
TRP C 150
VAL A 153
 None
 1.20A 5ubbA-4zrqA:
undetectable		 5ubbA-4zrqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 5 LEU A 113
LEU A 144
ALA A  88
LEU A  89
 None
 0.87A 5vkqA-4zrqA:
2.5
5vkqB-4zrqA:
2.5		 5vkqA-4zrqA:
14.46
5vkqB-4zrqA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 5 LEU A 113
LEU A 144
ALA A  88
LEU A  89
 None
 0.83A 5vkqB-4zrqA:
2.5
5vkqC-4zrqA:
2.5		 5vkqB-4zrqA:
14.46
5vkqC-4zrqA:
14.46