SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zrs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 9 GLY A 172
HIS A 167
ALA A 177
THR A 218
ILE A 174
 None
 1.49A 1c9sL-4zrsA:
undetectable
1c9sM-4zrsA:
undetectable		 1c9sL-4zrsA:
14.43
1c9sM-4zrsA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 9 GLY A 172
HIS A 167
ALA A 177
THR A 218
ILE A 174
 None
 1.48A 1gtfA-4zrsA:
undetectable
1gtfB-4zrsA:
undetectable		 1gtfA-4zrsA:
14.43
1gtfB-4zrsA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 9 GLY A 172
HIS A 167
ALA A 177
THR A 218
ILE A 174
 None
 1.49A 1gtnG-4zrsA:
undetectable
1gtnH-4zrsA:
undetectable		 1gtnG-4zrsA:
14.43
1gtnH-4zrsA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 9 GLY A 172
HIS A 167
ALA A 177
THR A 218
ILE A 174
 None
 1.48A 1gtnS-4zrsA:
undetectable
1gtnT-4zrsA:
undetectable		 1gtnS-4zrsA:
14.43
1gtnT-4zrsA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 THR A 225
VAL A 226
SER A 227
GLY A 182
GLY A  75
 None
None
None
SEB  A 151 ( 3.7A)
SEB  A 151 ( 3.8A)
 1.04A 1jg4A-4zrsA:
undetectable		 1jg4A-4zrsA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 TYR A 184
PHE A 234
SER A 227
ALA A 158
ALA A 154
 None
SEB  A 151 ( 4.5A)
None
None
SEB  A 151 ( 3.3A)
 1.28A 1q23A-4zrsA:
undetectable
1q23B-4zrsA:
undetectable		 1q23A-4zrsA:
19.38
1q23B-4zrsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zrs ESTERASE
(uncultured
bacterium) 		3 / 3 GLU A 273
THR A 272
LEU A   5
 None
 0.57A 1v8bC-4zrsA:
5.1		 1v8bC-4zrsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 GLY A 149
ILE A 270
ILE A 277
ALA A  97
ILE A  93
 None
 0.87A 2b60A-4zrsA:
undetectable		 2b60A-4zrsA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A  16
LEU A  21
GLY A  76
ALA A 152
ALA A 155
 SEB  A 151 ( 4.8A)
None
SEB  A 151 ( 3.5A)
SEB  A 151 ( 3.4A)
SEB  A 151 ( 4.0A)
 1.17A 2bm9D-4zrsA:
undetectable		 2bm9D-4zrsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 8 GLY A  75
GLY A  76
ALA A 152
HIS A 263
 SEB  A 151 ( 3.8A)
SEB  A 151 ( 3.5A)
SEB  A 151 ( 3.4A)
SEB  A 151 ( 4.1A)
 0.17A 2ha4A-4zrsA:
21.3		 2ha4A-4zrsA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  75
GLY A  76
ALA A 152
HIS A 263
 SEB  A 151 ( 3.8A)
SEB  A 151 ( 3.5A)
SEB  A 151 ( 3.4A)
SEB  A 151 ( 4.1A)
 0.16A 2ha4B-4zrsA:
21.7		 2ha4B-4zrsA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 8 ASP A  50
HIS A 115
SER A 119
HIS A 156
 None
 1.13A 2q0iA-4zrsA:
undetectable		 2q0iA-4zrsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  -1
GLY A 283
GLN A 100
PHE A  96
 None
 0.97A 2qwxA-4zrsA:
undetectable
2qwxB-4zrsA:
undetectable		 2qwxA-4zrsA:
21.15
2qwxB-4zrsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4zrs ESTERASE
(uncultured
bacterium) 		3 / 3 TRP A 245
VAL A 288
ARG A 286
 GOL  A 301 (-4.3A)
None
None
 0.87A 3b0wA-4zrsA:
undetectable		 3b0wA-4zrsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 PHE A  71
VAL A 103
GLY A 104
GLY A  94
LEU A 131
 None
 0.97A 3dh0A-4zrsA:
undetectable		 3dh0A-4zrsA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 VAL A  72
VAL A  70
LEU A  69
GLY A 176
LEU A 124
 None
 1.09A 3n8yB-4zrsA:
undetectable		 3n8yB-4zrsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  75
GLY A  76
PHE A 234
HIS A 263
 SEB  A 151 ( 3.8A)
SEB  A 151 ( 3.5A)
SEB  A 151 ( 4.5A)
SEB  A 151 ( 4.1A)
 0.41A 3o9mA-4zrsA:
21.5		 3o9mA-4zrsA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A  55
ILE A 145
VAL A  70
LEU A 147
VAL A 157
 None
 1.10A 3w68A-4zrsA:
3.3		 3w68A-4zrsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A  55
ILE A 145
VAL A  70
LEU A 147
VAL A 157
 None
 1.12A 3w68C-4zrsA:
0.0		 3w68C-4zrsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 7 TYR A  47
ASP A 123
HIS A  73
HIS A  53
 None
 1.24A 3zodA-4zrsA:
undetectable		 3zodA-4zrsA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 8 PHE A 102
SER A 148
ARG A 286
VAL A 146
 None
 1.38A 4d32A-4zrsA:
undetectable
4d32B-4zrsA:
undetectable		 4d32A-4zrsA:
22.30
4d32B-4zrsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 11 LEU A 147
ASP A 123
GLY A 120
PHE A 117
ALA A 126
 None
 1.19A 4fogD-4zrsA:
undetectable		 4fogD-4zrsA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 7 ASP A  50
ASP A 123
SER A 119
HIS A 115
 None
 0.95A 4k7gB-4zrsA:
0.5		 4k7gB-4zrsA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 8 MET A 255
MET A 223
MET A 280
LEU A 258
 None
 0.99A 4ok1A-4zrsA:
undetectable		 4ok1A-4zrsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4zrs ESTERASE
(uncultured
bacterium) 		6 / 12 LEU A 124
GLY A 149
GLY A 153
ILE A 174
LEU A 179
ALA A 177
 None
None
SEB  A 151 ( 4.0A)
None
None
None
 1.40A 5l0zA-4zrsA:
3.0		 5l0zA-4zrsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 4 GLN A  26
THR A  25
THR A 272
LEU A   5
 None
 1.34A 5m66B-4zrsA:
undetectable		 5m66B-4zrsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 8 ALA A 155
ILE A 161
ALA A 162
LEU A 215
 SEB  A 151 ( 4.0A)
None
None
None
 0.68A 5te8B-4zrsA:
undetectable		 5te8B-4zrsA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 ALA A 282
ALA A 162
THR A 218
LEU A 222
MET A 223
 None
None
None
GOL  A 301 (-4.5A)
None
 1.23A 5tl8A-4zrsA:
undetectable		 5tl8A-4zrsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zrs ESTERASE
(uncultured
bacterium) 		5 / 12 ALA A  97
GLN A 100
ARG A 286
ALA A 282
VAL A 135
 None
 0.96A 5uanA-4zrsA:
undetectable		 5uanA-4zrsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 5 LEU A 224
LEU A 222
MET A 280
TYR A 257
 None
GOL  A 301 (-4.5A)
None
None
 1.41A 5uc3A-4zrsA:
undetectable		 5uc3A-4zrsA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zrs ESTERASE
(uncultured
bacterium) 		3 / 3 SER A 159
HIS A 156
TYR A 198
 None
 0.91A 5y2tA-4zrsA:
undetectable		 5y2tA-4zrsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 4zrs ESTERASE
(uncultured
bacterium) 		4 / 4 MET A  79
GLY A  80
HIS A  73
GLY A  75
 None
None
None
SEB  A 151 ( 3.8A)
 1.45A 6fgdA-4zrsA:
3.7		 6fgdA-4zrsA:
22.00