SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		5 / 11 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 TRE  A 301 (-2.7A)
TRE  A 301 (-2.6A)
None
None
None
 1.34A 1mjqA-4zrwA:
undetectable
1mjqB-4zrwA:
undetectable		 1mjqA-4zrwA:
18.12
1mjqB-4zrwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		5 / 10 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 TRE  A 301 (-2.7A)
TRE  A 301 (-2.6A)
None
None
None
 1.31A 1mjqC-4zrwA:
undetectable
1mjqD-4zrwA:
undetectable		 1mjqC-4zrwA:
18.12
1mjqD-4zrwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		5 / 11 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 TRE  A 301 (-2.7A)
TRE  A 301 (-2.6A)
None
None
None
 1.32A 1mjqI-4zrwA:
undetectable
1mjqJ-4zrwA:
undetectable		 1mjqI-4zrwA:
18.12
1mjqJ-4zrwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		5 / 12 ALA A 102
LEU A 104
PHE A 197
SER A  99
TYR A 137
 None
 1.44A 3bxoB-4zrwA:
undetectable		 3bxoB-4zrwA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4zrw MINCLE PROTEIN
(Bos
taurus) 		4 / 6 TYR A  91
GLU A 121
THR A 119
GLN A  87
 None
 1.38A 4qztA-4zrwA:
undetectable		 4qztA-4zrwA:
22.15