SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zrx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 12 THR A 590
ASP A 588
ILE A 560
PHE A 557
ALA A 523
 None
 1.33A 1oltA-4zrxA:
undetectable		 1oltA-4zrxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		4 / 6 ASN A 493
ASN A 492
ARG A 496
GLY A 600
 None
 1.02A 1oniA-4zrxA:
undetectable
1oniB-4zrxA:
undetectable		 1oniA-4zrxA:
12.98
1oniB-4zrxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		4 / 6 ASN A 493
ASN A 492
ARG A 496
GLY A 600
 None
 1.00A 1oniD-4zrxA:
undetectable
1oniF-4zrxA:
undetectable		 1oniD-4zrxA:
12.98
1oniF-4zrxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		4 / 6 ARG A 496
GLY A 600
PRO A 566
THR A 568
 None
 1.26A 2m2oB-4zrxA:
undetectable		 2m2oB-4zrxA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 12 LEU A 299
ARG A 419
ALA A  47
ALA A  46
VAL A  43
 None
 0.98A 2oc8A-4zrxA:
undetectable		 2oc8A-4zrxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 12 PRO A  91
LEU A  94
ILE A 356
VAL A 111
LEU A  67
 None
 1.27A 3a51B-4zrxA:
undetectable		 3a51B-4zrxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 10 PHE A  66
ASP A 204
ILE A 238
HIS A  68
HIS A 117
 None
EDO  A 701 ( 3.5A)
EDO  A 701 (-4.5A)
EDO  A 703 (-3.9A)
EDO  A 703 (-4.1A)
 1.09A 3o1cA-4zrxA:
undetectable		 3o1cA-4zrxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 10 PHE A  66
ASP A 204
ILE A 238
HIS A  68
HIS A 117
 None
EDO  A 701 ( 3.5A)
EDO  A 701 (-4.5A)
EDO  A 703 (-3.9A)
EDO  A 703 (-4.1A)
 1.09A 3o1xA-4zrxA:
undetectable		 3o1xA-4zrxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 10 PHE A  66
ASP A 204
ILE A 238
HIS A  68
HIS A 117
 None
EDO  A 701 ( 3.5A)
EDO  A 701 (-4.5A)
EDO  A 703 (-3.9A)
EDO  A 703 (-4.1A)
 1.08A 3qgzA-4zrxA:
undetectable		 3qgzA-4zrxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 12 TYR A 180
ALA A 222
THR A 226
GLU A 190
THR A 189
 None
 1.22A 4fiaA-4zrxA:
undetectable		 4fiaA-4zrxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 12 TYR A 180
ALA A 222
THR A 226
GLU A 190
THR A 189
 None
 1.22A 4fiaA-4zrxA:
undetectable		 4fiaA-4zrxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 11 GLU A 148
LEU A  67
ASP A 351
LEU A 355
GLY A 354
 None
 1.31A 4foxC-4zrxA:
undetectable		 4foxC-4zrxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 12 ILE A 238
PHE A  66
PHE A 108
LEU A 330
LEU A 364
 EDO  A 701 (-4.5A)
None
None
None
None
 1.06A 4j03A-4zrxA:
2.7		 4j03A-4zrxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		4 / 6 ILE A 227
ILE A 185
PHE A 203
LEU A 164
 None
 0.86A 4m51A-4zrxA:
4.8		 4m51A-4zrxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		4 / 7 GLY A 443
SER A 472
ARG A 254
ASN A 259
 None
 1.09A 5n5dB-4zrxA:
undetectable		 5n5dB-4zrxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 4zrx F5/8 TYPE C DOMAIN
PROTEIN
(Bacteroides
ovatus) 		5 / 12 THR A 114
ASP A 119
HIS A 131
LEU A 123
PHE A 315
 None
 1.38A 6f3mB-4zrxA:
undetectable		 6f3mB-4zrxA:
22.26