SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4zry KERATIN, TYPE I
CYTOSKELETAL 10
KERATIN, TYPE II
CYTOSKELETAL 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLN A 387
LEU A 389
GLU A 390
LEU B 422
 None
 0.86A 3h5gA-4zryA:
undetectable
3h5gC-4zryA:
undetectable		 3h5gA-4zryA:
16.13
3h5gC-4zryA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4zry KERATIN, TYPE I
CYTOSKELETAL 10
KERATIN, TYPE II
CYTOSKELETAL 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU B 422
GLN A 387
LEU A 389
GLU A 390
 None
 1.02A 3h5gB-4zryB:
undetectable
3h5gC-4zryB:
undetectable		 3h5gB-4zryB:
15.00
3h5gC-4zryB:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4zry KERATIN, TYPE II
CYTOSKELETAL 1
(Homo
sapiens) 		3 / 3 LYS B 441
LEU B 437
ALA B 440
 None
 0.59A 4ikiA-4zryB:
undetectable		 4ikiA-4zryB:
20.15