SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zs6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zs6 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.44A 2y03A-4zs6H:
undetectable		 2y03A-4zs6H:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zs6 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.48A 2y03B-4zs6H:
undetectable		 2y03B-4zs6H:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zs6 FAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG H  98
HIS H 110
TYR H  32
 None
 1.05A 4fu8A-4zs6H:
undetectable		 4fu8A-4zs6H:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zs6 FAB HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG H  98
HIS H 110
TYR H  32
 None
 1.02A 4fu9A-4zs6H:
undetectable		 4fu9A-4zs6H:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zs6 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLY H 198
GLN H 200
VAL H 192
SER H 195
 None
 1.27A 5vunA-4zs6H:
undetectable		 5vunA-4zs6H:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4zs6 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.45A 6h7mB-4zs6H:
undetectable		 6h7mB-4zs6H:
15.42