SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zs8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4zs8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		5 / 12 SER A 223
LEU A 125
LEU A 176
LEU A 188
TYR A 177
 None
 1.29A 1fm6D-4zs8A:
undetectable		 1fm6D-4zs8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4zs8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 6 ALA A 126
ARG A 139
LEU A 129
TRP A 233
 None
 1.15A 1gahA-4zs8A:
undetectable		 1gahA-4zs8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 4zs8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		3 / 3 LEU A  31
HIS A  30
MET A  34
 None
 0.62A 3thrD-4zs8A:
undetectable		 3thrD-4zs8A:
22.98