SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		5 / 12 SER A 223
LEU A 125
LEU A 176
LEU A 188
TYR A 177
 None
 1.28A 1fm6D-4zsbA:
undetectable		 1fm6D-4zsbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		5 / 12 GLY A 135
ASP A 122
LYS A 161
ILE A 131
ASP A 130
 None
 1.39A 4pghB-4zsbA:
undetectable		 4pghB-4zsbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 5 THR A  99
GLU A 154
THR A 156
LEU A 188
 None
 1.25A 5hm8A-4zsbA:
undetectable		 5hm8A-4zsbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 5 THR A  99
GLU A 154
THR A 156
LEU A 188
 None
 1.26A 5hm8B-4zsbA:
undetectable		 5hm8B-4zsbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 5 THR A  99
GLU A 154
THR A 156
LEU A 188
 None
 1.26A 5hm8C-4zsbA:
undetectable		 5hm8C-4zsbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 5 THR A  99
GLU A 154
THR A 156
LEU A 188
 None
 1.26A 5hm8D-4zsbA:
undetectable		 5hm8D-4zsbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 5 THR A  99
GLU A 154
THR A 156
LEU A 188
 None
 1.26A 5hm8E-4zsbA:
undetectable		 5hm8E-4zsbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 5 THR A  99
GLU A 154
THR A 156
LEU A 188
 None
 1.26A 5hm8H-4zsbA:
undetectable		 5hm8H-4zsbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		5 / 12 ILE A 116
GLY A 117
LEU A 176
LEU A 180
LEU A 166
 None
 1.25A 5nfjB-4zsbA:
undetectable		 5nfjB-4zsbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR
(Streptomyces
coelicolor) 		4 / 5 THR A  99
GLU A 154
THR A 156
LEU A 188
 None
 1.19A 5utuH-4zsbA:
undetectable		 5utuH-4zsbA:
16.13