SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zsl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 TRP A 226
HIS A 145
LYS A 184
 GOL  A 406 (-3.7A)
None
None
 1.36A 1l7xA-4zslA:
1.0		 1l7xA-4zslA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 TYR A 164
TYR A 161
GLU A 356
PRO A 353
 None
 1.28A 1q13A-4zslA:
undetectable		 1q13A-4zslA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 7 LEU A 234
TYR A 297
MET A 275
ILE A 274
 None
 1.07A 1tuvA-4zslA:
undetectable		 1tuvA-4zslA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 229
GLU A 231
GLN A 241
LEU A 170
VAL A 248
 None
 1.29A 1u72A-4zslA:
undetectable		 1u72A-4zslA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 ILE A  61
VAL A  69
ILE A 114
ASP A 200
 None
 0.73A 1uwhA-4zslA:
21.2		 1uwhA-4zslA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 ALA A  82
ILE A 115
LEU A 137
ASP A 143
LEU A 189
 None
 0.91A 1yi4A-4zslA:
22.4		 1yi4A-4zslA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 ARG A 181
ASP A 200
ASP A 143
 None
 0.80A 2ejtA-4zslA:
undetectable		 2ejtA-4zslA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 None
 0.70A 2y7jA-4zslA:
26.1		 2y7jA-4zslA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 10 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 None
 0.63A 2y7jB-4zslA:
26.1		 2y7jB-4zslA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 10 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 None
 0.66A 2y7jC-4zslA:
26.2		 2y7jC-4zslA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 10 ILE A  61
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
LEU A 189
 None
 0.61A 2y7jD-4zslA:
26.1		 2y7jD-4zslA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A 341
LEU A 245
LEU A 170
ILE A 251
LEU A 188
 None
 1.19A 3datA-4zslA:
undetectable		 3datA-4zslA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A  82
GLU A 102
LEU A 106
ILE A 115
ASP A 200
 None
4QZ  A 401 (-4.3A)
4QZ  A 401 ( 4.7A)
None
None
 1.01A 3gcsA-4zslA:
34.7		 3gcsA-4zslA:
44.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 VAL A  69
ALA A  82
GLU A 102
LEU A 106
ILE A 115
 None
None
4QZ  A 401 (-4.3A)
4QZ  A 401 ( 4.7A)
None
 0.88A 3gcsA-4zslA:
34.7		 3gcsA-4zslA:
44.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 VAL A  69
ALA A  82
GLU A 102
LEU A 106
ILE A 115
ASP A 200
 None
None
4QZ  A 401 (-4.3A)
4QZ  A 401 ( 4.7A)
None
None
 1.24A 3hegA-4zslA:
35.7		 3hegA-4zslA:
45.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		7 / 12 ALA A  82
LEU A 137
LEU A 139
MET A 140
ASP A 143
LEU A 189
GLY A 199
 None
 0.88A 3zbfA-4zslA:
22.6		 3zbfA-4zslA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 PHE A  90
ILE A  86
PRO A  87
PHE A 130
 None
4QZ  A 401 (-4.4A)
None
None
 1.09A 4fgkA-4zslA:
undetectable		 4fgkA-4zslA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 7 GLY A  67
ASP A 143
ASN A 187
LEU A 189
ASP A 200
 4QZ  A 401 ( 4.1A)
None
None
None
None
 1.11A 4ogrE-4zslA:
29.7		 4ogrE-4zslA:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 ASP A  53
ARG A 392
ARG A 122
 None
 0.61A 4x5iA-4zslA:
undetectable		 4x5iA-4zslA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 ALA A  82
LEU A 139
MET A 140
LEU A 189
 None
 0.40A 4xoyA-4zslA:
37.6		 4xoyA-4zslA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 ALA A  82
LEU A 139
MET A 140
LEU A 189
 None
 0.42A 4xp3A-4zslA:
38.4		 4xp3A-4zslA:
48.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		3 / 3 ASP A  53
ARG A 392
ARG A 122
 None
 0.78A 5eajB-4zslA:
undetectable		 5eajB-4zslA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 9 ILE A  61
GLY A  62
VAL A  69
ALA A  82
ILE A 115
LEU A 189
 None
 1.46A 5lw1B-4zslA:
33.8		 5lw1B-4zslA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 GLY A  62
VAL A  69
ALA A  82
ILE A 115
LEU A 139
 None
 0.79A 5lw1E-4zslA:
33.4		 5lw1E-4zslA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 10 MET A 203
ALA A 204
PHE A 365
PHE A 363
VAL A 178
 None
 1.48A 6hu9C-4zslA:
undetectable		 6hu9C-4zslA:
20.25