SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus)
4 / 6 LYS A  85
ALA A  82
GLU A  19
GLU A  18
None
1.24A 1qhyA-4zsxA:
undetectable
1qhyA-4zsxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Aquifex
aeolicus;
Pseudomonas
aeruginosa)
5 / 10 TYR A  87
PHE A  77
TYR A 131
LEU A  50
LEU A  48
None
1.49A 2w98A-4zsxA:
undetectable
2w98A-4zsxA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus)
5 / 10 ILE A  15
GLY A  79
PHE A  78
VAL A  66
LEU A  42
None
1.23A 3elzB-4zsxA:
2.6
3elzB-4zsxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus)
4 / 6 TYR A 101
GLY A 114
THR A 107
GLU A 174
None
1.00A 3fpjA-4zsxA:
undetectable
3fpjA-4zsxA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus)
3 / 3 HIS A 208
HIS A 212
ILE A 211
None
0.85A 3u52A-4zsxA:
undetectable
3u52C-4zsxA:
undetectable
3u52A-4zsxA:
19.49
3u52C-4zsxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus)
5 / 12 LEU A 218
GLY A 273
ASP A 274
ARG A 216
ALA A 232
None
1.14A 5h5fA-4zsxA:
undetectable
5h5fA-4zsxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Aquifex
aeolicus;
Pseudomonas
aeruginosa)
4 / 5 LEU A 218
CYH A 214
CYH A 285
ASP A 234
None
1.50A 5mafA-4zsxA:
3.0
5mafA-4zsxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus)
3 / 3 LEU A  42
ILE A  22
TYR A  87
None
0.69A 5uunB-4zsxA:
undetectable
5uunB-4zsxA:
23.89