SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ztb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 8 GLY A 240
SER A 242
PHE A 296
PHE A 275
 None
 0.95A 1ax9A-4ztbA:
undetectable		 1ax9A-4ztbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 11 HIS A 140
HIS A 309
THR A 308
ILE A 268
ALA A 280
 None
 1.11A 1gtnM-4ztbA:
undetectable
1gtnN-4ztbA:
undetectable		 1gtnM-4ztbA:
14.60
1gtnN-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 5 SER A  66
ASN A  91
ALA A  94
GLU A  93
 None
 1.41A 1lqtA-4ztbA:
undetectable
1lqtB-4ztbA:
undetectable		 1lqtA-4ztbA:
20.39
1lqtB-4ztbA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 5 SER A  66
ASN A  91
ALA A  94
GLU A  93
 None
 1.41A 1lquA-4ztbA:
undetectable
1lquB-4ztbA:
undetectable		 1lquA-4ztbA:
20.39
1lquB-4ztbA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 LEU A 157
LEU A 174
GLU A 291
HIS A 217
TYR A 172
 GOL  A 401 ( 4.8A)
None
None
None
None
 1.39A 1mmkA-4ztbA:
undetectable		 1mmkA-4ztbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 11 LEU A 157
LEU A 174
GLU A 291
HIS A 217
TYR A 172
 GOL  A 401 ( 4.8A)
None
None
None
None
 1.36A 1mmtA-4ztbA:
undetectable		 1mmtA-4ztbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 CYH A 285
TYR A 172
LEU A 174
LEU A 253
HIS A 217
 GOL  A 401 ( 4.5A)
None
None
None
None
 1.09A 1zgyA-4ztbA:
undetectable		 1zgyA-4ztbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 ASN A 110
LEU A  13
ILE A  51
ALA A  47
LEU A  60
 None
 1.02A 3a50A-4ztbA:
undetectable		 3a50A-4ztbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 CYH A 285
TYR A 172
LEU A 174
LEU A 253
HIS A 217
 GOL  A 401 ( 4.5A)
None
None
None
None
 1.14A 3dzyD-4ztbA:
undetectable		 3dzyD-4ztbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 TYR A 172
LEU A 174
VAL A 158
LEU A 253
HIS A 217
 None
 1.35A 3dzyD-4ztbA:
undetectable		 3dzyD-4ztbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 CYH A 285
ARG A 153
TYR A 172
LEU A 174
HIS A 217
 GOL  A 401 ( 4.5A)
None
None
None
None
 1.15A 3qt0A-4ztbA:
undetectable		 3qt0A-4ztbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		3 / 3 THR A 308
ASN A 312
GLU A 265
 None
 0.76A 3v4tA-4ztbA:
2.9
3v4tC-4ztbA:
undetectable		 3v4tA-4ztbA:
22.56
3v4tC-4ztbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 CYH A 285
TYR A 172
LEU A 174
LEU A 253
HIS A 217
 GOL  A 401 ( 4.5A)
None
None
None
None
 0.99A 3vn2A-4ztbA:
undetectable		 3vn2A-4ztbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 HIS A 217
ILE A 216
LEU A 238
LEU A 206
TYR A 172
 None
 1.37A 3vn2A-4ztbA:
undetectable		 3vn2A-4ztbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 5 HIS A 146
SER A 288
GLN A 227
VAL A 286
 None
 1.34A 4a99D-4ztbA:
undetectable		 4a99D-4ztbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 8 ARG A 136
MET A 292
PHE A 294
ILE A 268
 None
 0.95A 4j4vC-4ztbA:
undetectable		 4j4vC-4ztbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 7 ASN A 173
TYR A 194
TYR A 196
LEU A 198
 None
 1.23A 4yv5A-4ztbA:
undetectable		 4yv5A-4ztbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 7 ASN A 173
TYR A 194
TYR A 196
LEU A 198
 None
 1.17A 4yv5B-4ztbA:
undetectable		 4yv5B-4ztbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5eeuF-4ztbA:
undetectable
5eeuG-4ztbA:
undetectable		 5eeuF-4ztbA:
14.60
5eeuG-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.04A 5eeuI-4ztbA:
undetectable
5eeuJ-4ztbA:
undetectable		 5eeuI-4ztbA:
14.60
5eeuJ-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 HIS A 140
HIS A 309
THR A 308
ILE A 268
ALA A 280
 None
 1.08A 5eeuQ-4ztbA:
undetectable
5eeuR-4ztbA:
undetectable		 5eeuQ-4ztbA:
14.60
5eeuR-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5eevF-4ztbA:
undetectable
5eevG-4ztbA:
undetectable		 5eevF-4ztbA:
14.60
5eevG-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.04A 5eevI-4ztbA:
undetectable
5eevJ-4ztbA:
undetectable		 5eevI-4ztbA:
14.60
5eevJ-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 HIS A 140
HIS A 309
THR A 308
ILE A 268
ALA A 280
 None
 1.08A 5eevQ-4ztbA:
undetectable
5eevR-4ztbA:
undetectable		 5eevQ-4ztbA:
14.60
5eevR-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5eewF-4ztbA:
undetectable
5eewG-4ztbA:
undetectable		 5eewF-4ztbA:
14.60
5eewG-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 12 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.05A 5eewI-4ztbA:
undetectable
5eewJ-4ztbA:
undetectable		 5eewI-4ztbA:
14.60
5eewJ-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 HIS A 140
HIS A 309
THR A 308
ILE A 268
ALA A 280
 None
 1.08A 5eewQ-4ztbA:
undetectable
5eewR-4ztbA:
undetectable		 5eewQ-4ztbA:
14.60
5eewR-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5eexF-4ztbA:
undetectable
5eexG-4ztbA:
undetectable		 5eexF-4ztbA:
14.60
5eexG-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5eeyF-4ztbA:
undetectable
5eeyG-4ztbA:
undetectable		 5eeyF-4ztbA:
14.60
5eeyG-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5eezF-4ztbA:
undetectable
5eezG-4ztbA:
undetectable		 5eezF-4ztbA:
14.60
5eezG-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5ef0F-4ztbA:
undetectable
5ef0G-4ztbA:
undetectable		 5ef0F-4ztbA:
14.60
5ef0G-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5ef1F-4ztbA:
undetectable
5ef1G-4ztbA:
undetectable		 5ef1F-4ztbA:
14.60
5ef1G-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5ef2F-4ztbA:
undetectable
5ef2G-4ztbA:
undetectable		 5ef2F-4ztbA:
14.60
5ef2G-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		5 / 10 ALA A 280
HIS A 140
HIS A 309
THR A 308
ILE A 268
 None
 1.03A 5ef3F-4ztbA:
undetectable
5ef3G-4ztbA:
undetectable		 5ef3F-4ztbA:
14.60
5ef3G-4ztbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 4ztb PROTEASE NSP2
(Chikungunya
virus) 		4 / 4 ARG A 262
SER A  62
ASP A  61
ASN A  49
 None
 1.34A 6ag0A-4ztbA:
undetectable		 6ag0A-4ztbA:
16.61