SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ztc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		5 / 12 ILE A 237
GLY A 182
SER A   6
GLY A 191
SER A 179
 None
4RA  A 401 (-3.1A)
None
None
4RA  A 401 (-2.6A)
 1.16A 1nbiA-4ztcA:
undetectable		 1nbiA-4ztcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		5 / 12 ILE A 237
GLY A 182
SER A   6
GLY A 191
SER A 179
 None
4RA  A 401 (-3.1A)
None
None
4RA  A 401 (-2.6A)
 1.16A 1nbiB-4ztcA:
undetectable		 1nbiB-4ztcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 6 ALA A  77
LEU A  76
SER A  79
CYH A  90
 None
 0.98A 1sbrA-4ztcA:
undetectable
1sbrB-4ztcA:
undetectable		 1sbrA-4ztcA:
20.97
1sbrB-4ztcA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		3 / 3 ARG A 280
TYR A 256
LYS A 260
 None
 0.89A 1uujB-4ztcA:
0.1		 1uujB-4ztcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 5 PHE A 267
LEU A 317
PHE A 269
SER A 364
 None
 1.29A 1wrkB-4ztcA:
undetectable		 1wrkB-4ztcA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 6 TYR A 178
TYR A  44
TYR A 180
ILE A 186
 None
 1.29A 2pgzD-4ztcA:
undetectable
2pgzE-4ztcA:
undetectable		 2pgzD-4ztcA:
19.11
2pgzE-4ztcA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		5 / 12 TYR A 180
PRO A  29
ALA A  28
ALA A  56
ALA A  59
 None
None
None
4RA  A 401 (-3.4A)
None
 1.30A 2x2nB-4ztcA:
undetectable		 2x2nB-4ztcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		3 / 3 VAL A 249
LYS A 252
HIS A 130
 None
 0.78A 3elzA-4ztcA:
undetectable		 3elzA-4ztcA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 7 ASN A 106
ALA A 136
ARG A 277
ALA A 159
 None
 1.06A 3twpC-4ztcA:
undetectable		 3twpC-4ztcA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 7 VAL A 373
SER A 283
TYR A 259
MET A 368
 None
 1.05A 4hxyB-4ztcA:
undetectable		 4hxyB-4ztcA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 5 VAL A  75
LEU A  64
ILE A 127
LEU A 126
 None
 0.85A 4mghA-4ztcA:
undetectable		 4mghA-4ztcA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		5 / 10 ALA A  63
VAL A 151
GLY A 196
ILE A 195
ILE A 153
 None
 1.08A 4njuB-4ztcA:
undetectable		 4njuB-4ztcA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		5 / 10 ALA A  63
VAL A 151
GLY A 196
ILE A 195
ILE A 153
 None
 1.10A 4njuD-4ztcA:
undetectable		 4njuD-4ztcA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 6 LEU A 160
ILE A 185
LEU A 245
GLU A 246
 None
 0.92A 4w5nA-4ztcA:
undetectable		 4w5nA-4ztcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		3 / 3 MET A 138
HIS A 130
GLY A 173
 None
 0.86A 5gwzB-4ztcA:
undetectable		 5gwzB-4ztcA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 5 TYR A 132
VAL A 109
PHE A 356
GLY A 359
 None
 1.41A 6hd4A-4ztcA:
undetectable		 6hd4A-4ztcA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4ztc AMINOTRANSFERASE
HOMOLOG
(Campylobacter
jejuni) 		4 / 4 ASP A  73
ILE A  89
PRO A  88
LEU A  92
 None
 1.33A 6mkeA-4ztcA:
undetectable		 6mkeA-4ztcA:
11.83