SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ztd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		5 / 11 THR A 224
PHE A 144
LEU A 182
VAL A 167
PHE A 169
 None
 1.46A 1q23G-4ztdA:
undetectable		 1q23G-4ztdA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		5 / 12 LEU A 182
PHE A 144
ILE A 160
LEU A 235
CYH A 148
 None
 0.99A 2oipD-4ztdA:
undetectable		 2oipD-4ztdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		5 / 12 VAL A  15
LEU A  16
LEU A  99
ILE A  88
LEU A  52
 None
 1.06A 3n8zB-4ztdA:
undetectable		 3n8zB-4ztdA:
18.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		6 / 6 MET A  40
LEU A  47
PRO A 129
GLN A 131
PRO A 234
TYR A 250
 None
 0.86A 3vkxA-4ztdA:
36.5		 3vkxA-4ztdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		5 / 12 ALA A 218
SER A  10
MET A 244
LEU A   6
VAL A   7
 None
 1.11A 4eckA-4ztdA:
undetectable		 4eckA-4ztdA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		3 / 3 PHE A 144
TYR A 249
TYR A 239
 None
 1.02A 4ffwA-4ztdA:
undetectable		 4ffwA-4ztdA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		4 / 6 LEU A  79
MET A 116
LEU A  90
ILE A  87
 None
 1.12A 4okxA-4ztdA:
undetectable		 4okxA-4ztdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		4 / 7 PHE A  57
ASP A  58
THR A  89
ILE A  88
 None
 1.09A 4pcuA-4ztdA:
undetectable		 4pcuA-4ztdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		4 / 7 LEU A 227
VAL A 136
GLU A 198
ILE A 128
 None
 1.11A 5jh7C-4ztdA:
undetectable		 5jh7C-4ztdA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		5 / 9 VAL A  35
LEU A  52
ILE A  88
MET A  75
ALA A   4
 None
 1.10A 5og9A-4ztdA:
undetectable		 5og9A-4ztdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		5 / 12 VAL A  35
LEU A  52
ILE A  88
LEU A  16
ALA A   4
 None
 1.16A 5og9B-4ztdA:
undetectable		 5og9B-4ztdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens) 		5 / 12 ASN A  36
LEU A  50
ASP A 243
GLY A  56
PHE A  57
 None
 1.37A 6dwnA-4ztdA:
undetectable		 6dwnA-4ztdA:
15.98