SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 4 HIS A 196
LEU A  77
LEU A 151
LEU A 158
 None
 1.11A 1a4lD-4ztiA:
undetectable		 1a4lD-4ztiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 ASN A 146
ASN A 228
ASP A 229
ILE A 232
LEU A  77
 None
 1.13A 1r30A-4ztiA:
undetectable		 1r30A-4ztiA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 11 LEU A  77
LEU A  74
ILE A  56
PHE A  66
LEU A 117
 None
 1.22A 2qeiA-4ztiA:
undetectable		 2qeiA-4ztiA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 6 GLY A 101
GLY A  94
PHE A 212
PHE A 208
 None
 0.84A 2qx6A-4ztiA:
undetectable
2qx6B-4ztiA:
undetectable		 2qx6A-4ztiA:
23.78
2qx6B-4ztiA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		3 / 3 LYS A 281
LYS A 274
VAL A 277
 None
 1.04A 3brfA-4ztiA:
undetectable		 3brfA-4ztiA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 ASP A 226
GLY A 148
ALA A 147
ASN A 146
LEU A 214
 None
 0.90A 3uq6B-4ztiA:
undetectable		 3uq6B-4ztiA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 8 GLN A 175
HIS A 179
VAL A 178
GLN A 182
 None
 1.15A 3uy4A-4ztiA:
undetectable		 3uy4A-4ztiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 12 ASP A 226
GLY A 148
ALA A 147
ASN A 146
LEU A 214
 None
 0.93A 3vaqB-4ztiA:
undetectable		 3vaqB-4ztiA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 6 ARG A 298
LEU A 244
ALA A 294
LEU A 284
 None
 0.87A 4wboC-4ztiA:
undetectable		 4wboC-4ztiA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		5 / 9 ALA A 297
GLY A 243
LEU A 244
LEU A 287
GLU A 309
 None
 1.06A 5dqfA-4ztiA:
2.6		 5dqfA-4ztiA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 6 LEU A  79
PHE A 106
LEU A 209
HIS A 216
 None
 0.98A 5gs4A-4ztiA:
undetectable		 5gs4A-4ztiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN
(Zaire
ebolavirus) 		4 / 5 ARG A 240
PHE A 296
LEU A 158
LEU A 245
 None
 1.09A 5veuH-4ztiA:
undetectable		 5veuH-4ztiA:
22.72