SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ztx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 ARG A 144
PHE A  63
LEU A  18
LEU A  35
LEU A  91
 GOL  A3001 (-3.5A)
None
None
None
GOL  A3001 (-4.5A)
 1.22A 1e7wA-4ztxA:
undetectable		 1e7wA-4ztxA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 SER A 547
HIS A 492
TYR A 503
PHE A 504
 None
 1.27A 1eqbA-4ztxA:
undetectable
1eqbB-4ztxA:
undetectable		 1eqbA-4ztxA:
20.10
1eqbB-4ztxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 TYR A 503
PHE A 504
SER A 547
HIS A 492
 None
 1.25A 1eqbA-4ztxA:
undetectable
1eqbB-4ztxA:
undetectable		 1eqbA-4ztxA:
20.10
1eqbB-4ztxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 SER A 547
HIS A 492
TYR A 503
PHE A 504
 None
 1.27A 1eqbC-4ztxA:
undetectable
1eqbD-4ztxA:
undetectable		 1eqbC-4ztxA:
20.10
1eqbD-4ztxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 TYR A 503
PHE A 504
SER A 547
HIS A 492
 None
 1.25A 1eqbC-4ztxA:
undetectable
1eqbD-4ztxA:
undetectable		 1eqbC-4ztxA:
20.10
1eqbD-4ztxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 SER A 554
GLY A 560
HIS A 492
ALA A 551
ILE A 603
 None
 1.28A 1gtnG-4ztxA:
undetectable
1gtnH-4ztxA:
undetectable		 1gtnG-4ztxA:
6.50
1gtnH-4ztxA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A 560
HIS A 492
ALA A 551
ILE A 603
SER A 554
 None
 1.26A 1gtnS-4ztxA:
undetectable
1gtnT-4ztxA:
undetectable		 1gtnS-4ztxA:
6.50
1gtnT-4ztxA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 6 ALA A  45
LYS A  48
ASP A  52
ALA A  53
 None
 0.24A 1iwhA-4ztxA:
undetectable		 1iwhA-4ztxA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 11 ALA A 245
GLU A 210
ASP A 209
ILE A 232
LEU A 195
 None
 1.00A 1jomA-4ztxA:
undetectable		 1jomA-4ztxA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 6 ILE A 733
ARG A 762
ASP A 488
LEU A 487
 None
 1.04A 1mt1B-4ztxA:
undetectable
1mt1C-4ztxA:
undetectable		 1mt1B-4ztxA:
9.55
1mt1C-4ztxA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 5 HIS A 705
ARG A 742
ILE A 733
HIS A 652
 None
None
None
ZN  A1000 (-3.2A)
 1.40A 1osvB-4ztxA:
undetectable		 1osvB-4ztxA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 LEU A 629
ILE A 665
PHE A 658
TYR A 628
PHE A 653
 None
 1.40A 1td7A-4ztxA:
undetectable		 1td7A-4ztxA:
8.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		6 / 8 ARG A  16
LYS A  19
HIS A 122
SER A 521
VAL A 527
TRP A 571
 None
 0.44A 1u1jA-4ztxA:
53.2		 1u1jA-4ztxA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 ALA A 550
GLY A 442
GLY A 493
LEU A 739
ILE A 441
 None
 0.97A 1x1aA-4ztxA:
undetectable		 1x1aA-4ztxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 ASN A 300
TRP A 302
GLN A 580
 None
 1.43A 1xoqA-4ztxA:
undetectable		 1xoqA-4ztxA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XPG_A_C2FA1882_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		6 / 9 LYS A  19
LYS A 115
ASP A 499
SER A 521
CYH A 526
GLU A 615
 None
 1.10A 1xpgA-4ztxA:
52.1		 1xpgA-4ztxA:
40.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XPG_A_C2FA1882_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 LYS A  19
LYS A 115
SER A 521
CYH A 526
TRP A 571
 None
 0.82A 1xpgA-4ztxA:
52.1		 1xpgA-4ztxA:
40.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XPG_B_C2FB1883_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		7 / 10 ARG A  16
LYS A  19
LYS A 115
TRP A 518
SER A 521
CYH A 526
TRP A 571
 None
 0.84A 1xpgB-4ztxA:
52.8		 1xpgB-4ztxA:
40.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XPG_B_C2FB1883_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		7 / 10 LYS A  19
LYS A 115
TRP A 518
SER A 521
CYH A 526
TRP A 571
GLU A 615
 None
 1.17A 1xpgB-4ztxA:
52.8		 1xpgB-4ztxA:
40.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 11 ASP A 297
ASN A 300
LEU A 346
LYS A 360
LEU A 340
 None
 1.31A 1xpqC-4ztxA:
0.0		 1xpqC-4ztxA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XR2_A_C2FA1200_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		7 / 9 ARG A  16
LYS A  19
LYS A 115
SER A 521
CYH A 526
PRO A 611
GLU A 615
 None
 0.99A 1xr2A-4ztxA:
50.2		 1xr2A-4ztxA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XR2_A_C2FA1200_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		7 / 9 ARG A  16
LYS A  19
LYS A 115
SER A 521
CYH A 526
TRP A 571
PRO A 611
 None
 0.84A 1xr2A-4ztxA:
50.2		 1xr2A-4ztxA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 8 LYS A  19
LYS A 115
TRP A 518
SER A 521
GLU A 615
 None
 1.37A 1xr2B-4ztxA:
51.5		 1xr2B-4ztxA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 8 LYS A  19
LYS A 115
TRP A 518
SER A 521
TRP A 571
 None
 0.98A 1xr2B-4ztxA:
51.5		 1xr2B-4ztxA:
40.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 PRO A 735
LEU A 751
GLY A 749
LEU A 739
 None
 0.84A 1ya4A-4ztxA:
undetectable		 1ya4A-4ztxA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 7 PRO A 735
LEU A 751
GLY A 749
LEU A 739
 None
 0.87A 1ya4B-4ztxA:
undetectable		 1ya4B-4ztxA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 LEU A 187
VAL A 221
ALA A 224
SER A 165
LEU A 167
 None
 1.24A 2c12C-4ztxA:
undetectable		 2c12C-4ztxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 11 LEU A 187
VAL A 221
ALA A 224
SER A 165
LEU A 167
 None
 1.20A 2c12F-4ztxA:
undetectable		 2c12F-4ztxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 PHE A 444
VAL A 747
TRP A 744
 None
 0.86A 2cc8A-4ztxA:
undetectable		 2cc8A-4ztxA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 PHE A 444
VAL A 747
TRP A 744
 None
 0.86A 2ccbA-4ztxA:
undetectable		 2ccbA-4ztxA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 LEU A 508
LEU A 589
ALA A 588
MET A 542
LEU A 562
 None
 1.39A 2oaxD-4ztxA:
undetectable		 2oaxD-4ztxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 7 ILE A 733
ARG A 762
ASP A 488
LEU A 487
 None
 1.07A 2qqcB-4ztxA:
undetectable
2qqcC-4ztxA:
undetectable		 2qqcB-4ztxA:
10.31
2qqcC-4ztxA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 ARG A 157
PRO A 158
ILE A 334
HIS A 335
GLY A 298
 None
 1.39A 2vufB-4ztxA:
1.7		 2vufB-4ztxA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 PHE A 444
VAL A 747
TRP A 744
 None
 0.87A 2vx9A-4ztxA:
undetectable		 2vx9A-4ztxA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 ILE A 301
ALA A 517
ILE A 531
PHE A 354
 None
 0.75A 2w9sE-4ztxA:
undetectable		 2w9sE-4ztxA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 TYR A 503
GLU A 506
THR A 458
 None
 1.01A 2y7hB-4ztxA:
undetectable		 2y7hB-4ztxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 7 TRP A 571
VAL A 527
SER A 521
HIS A 122
 None
 1.21A 3arrA-4ztxA:
9.3		 3arrA-4ztxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 ALA A 682
LEU A 685
MET A 722
ILE A 704
 None
 0.84A 3cldB-4ztxA:
undetectable		 3cldB-4ztxA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.44A 3fhjD-4ztxA:
undetectable		 3fhjD-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.44A 3fhjF-4ztxA:
undetectable		 3fhjF-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.38A 3fi0A-4ztxA:
undetectable		 3fi0A-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.41A 3fi0C-4ztxA:
undetectable		 3fi0C-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.42A 3fi0D-4ztxA:
undetectable		 3fi0D-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.39A 3fi0F-4ztxA:
undetectable		 3fi0F-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.45A 3fi0H-4ztxA:
undetectable		 3fi0H-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.37A 3fi0J-4ztxA:
undetectable		 3fi0J-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.47A 3fi0K-4ztxA:
undetectable		 3fi0K-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.40A 3fi0L-4ztxA:
undetectable		 3fi0L-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.43A 3fi0M-4ztxA:
undetectable		 3fi0M-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.44A 3fi0N-4ztxA:
undetectable		 3fi0N-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 GLY A  54
ASP A  56
VAL A 364
VAL A 361
GLN A  50
 None
 1.39A 3fi0R-4ztxA:
undetectable		 3fi0R-4ztxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 5 ILE A 603
ARG A 497
THR A 543
GLU A 496
 None
 1.37A 3ny4A-4ztxA:
undetectable		 3ny4A-4ztxA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 LEU A 591
ARG A 592
GLY A 564
THR A 567
LEU A 638
 None
 1.25A 3okxA-4ztxA:
undetectable		 3okxA-4ztxA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 7 VAL A 178
PHE A 166
GLY A 170
PHE A 134
 None
 1.00A 4ejjB-4ztxA:
undetectable		 4ejjB-4ztxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 11 TYR A 604
GLY A 560
GLU A 494
HIS A 492
GLY A 493
 None
 1.26A 4ey7A-4ztxA:
undetectable		 4ey7A-4ztxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 LEU A 267
LEU A 291
LEU A 320
ILE A 251
THR A 315
 None
 1.11A 4f4dB-4ztxA:
undetectable		 4f4dB-4ztxA:
18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 7 LYS A  19
TRP A 518
SER A 521
VAL A 527
TRP A 571
 None
 0.29A 4l64A-4ztxA:
64.0		 4l64A-4ztxA:
60.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L65_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 LYS A  19
ASN A 120
ASP A 499
VAL A 527
TRP A 571
 None
GOL  A3002 (-4.2A)
None
None
None
 0.94A 4l65A-4ztxA:
64.5		 4l65A-4ztxA:
60.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L65_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 9 LYS A  19
ASN A 120
SER A 521
VAL A 527
TRP A 571
 None
GOL  A3002 (-4.2A)
None
None
None
 0.61A 4l65A-4ztxA:
64.5		 4l65A-4ztxA:
60.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		7 / 10 LYS A  19
ASP A 499
TRP A 518
SER A 521
VAL A 527
PRO A 530
TRP A 571
 None
 0.38A 4l6hA-4ztxA:
63.7		 4l6hA-4ztxA:
60.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		7 / 10 LYS A  19
TRP A 518
SER A 521
TYR A 522
VAL A 527
PRO A 530
TRP A 571
 None
 0.93A 4l6hA-4ztxA:
63.7		 4l6hA-4ztxA:
60.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 GLY A 286
PRO A 287
LEU A 258
THR A 246
GLY A 266
 None
 1.21A 4n48A-4ztxA:
undetectable		 4n48A-4ztxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 4 ALA A 383
ALA A 386
ALA A 387
ALA A 390
 None
 0.10A 4oadA-4ztxA:
undetectable		 4oadA-4ztxA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 4 ALA A 383
ALA A 386
ALA A 387
ALA A 390
 None
 0.09A 4oaeA-4ztxA:
undetectable		 4oaeA-4ztxA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 PRO A 445
LEU A 739
GLN A 482
 None
 0.69A 4pevB-4ztxA:
2.0		 4pevB-4ztxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 ASP A 107
LYS A 103
LEU A  88
 None
 0.99A 4ptjA-4ztxA:
undetectable		 4ptjA-4ztxA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 ASP A 499
GLU A 494
SER A 521
 None
 0.84A 5bw4B-4ztxA:
undetectable		 5bw4B-4ztxA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 LEU A 169
GLY A 162
VAL A 212
PRO A 211
GLY A   8
 None
 1.35A 5f9zA-4ztxA:
undetectable		 5f9zA-4ztxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 GLY A 700
ALA A 750
VAL A 491
LEU A 739
GLY A 738
 None
 0.84A 5hieD-4ztxA:
undetectable		 5hieD-4ztxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 VAL A 161
GLU A 210
HIS A  68
SER A 165
PHE A 117
 None
 1.31A 5hnxB-4ztxA:
1.5		 5hnxB-4ztxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 VAL A 161
GLU A 210
HIS A  68
SER A 165
PHE A 117
 None
 1.35A 5hnzB-4ztxA:
2.7		 5hnzB-4ztxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 4 CYH A 568
LEU A 591
LEU A 587
ALA A 590
 None
 1.09A 5hpuA-4ztxA:
undetectable
5hpuB-4ztxA:
undetectable		 5hpuA-4ztxA:
2.24
5hpuB-4ztxA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 ILE A 232
SER A 165
VAL A 244
ILE A 208
PRO A 163
 None
 1.37A 5mlmA-4ztxA:
2.1		 5mlmA-4ztxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 VAL A 161
GLU A 210
HIS A  68
SER A 165
PHE A 117
 None
 1.39A 5nd2B-4ztxA:
undetectable		 5nd2B-4ztxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 4 VAL A 269
LEU A 282
ASN A 274
ASP A 250
 None
 1.02A 5vcyA-4ztxA:
undetectable		 5vcyA-4ztxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		4 / 8 ILE A 334
GLN A  50
ASP A  62
ASP A  71
 None
 1.02A 5vlmH-4ztxA:
undetectable		 5vlmH-4ztxA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 GLU A 494
ARG A 497
VAL A 747
LEU A 751
GLY A 738
 None
 1.15A 5vooE-4ztxA:
7.7		 5vooE-4ztxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		5 / 12 HIS A 268
GLY A 294
ILE A 334
GLY A 298
PHE A 248
 None
 1.17A 6c2mB-4ztxA:
undetectable		 6c2mB-4ztxA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE
(Neurospora
crassa) 		3 / 3 ARG A 391
ARG A 575
ASP A 577
 None
 0.47A 6d8pA-4ztxA:
2.3		 6d8pA-4ztxA:
22.37