SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 147
PHE A 152
ARG A  40
ASN A  88
 IOD  A 304 (-4.7A)
None
IOD  A 305 (-4.4A)
IOD  A 304 (-4.0A)
 1.35A 1t9wA-4zu2A:
3.1		 1t9wA-4zu2A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  95
ILE A 149
MET A  31
LEU A 197
VAL A 106
 None
IOD  A 304 ( 4.7A)
None
None
None
 1.36A 2n27A-4zu2A:
undetectable		 2n27A-4zu2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  53
VAL A 126
THR A 200
 None
 0.80A 2nmzA-4zu2A:
undetectable		 2nmzA-4zu2A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 114
ALA A 121
ALA A 177
PHE A 172
 None
 0.67A 2vcvP-4zu2A:
undetectable		 2vcvP-4zu2A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 137
GLY A 117
GLY A 115
ALA A 121
LEU A  94
 None
None
IOD  A 302 ( 4.6A)
None
None
 0.95A 3dh0B-4zu2A:
undetectable		 3dh0B-4zu2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  62
GLU A 110
PHE A  64
ALA A 112
ASP A  61
 None
 1.27A 3id5B-4zu2A:
undetectable		 3id5B-4zu2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  62
GLU A 110
PHE A  64
ALA A 112
ASP A  61
 None
 1.27A 3id5F-4zu2A:
undetectable		 3id5F-4zu2A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  53
VAL A 126
THR A 200
 None
 0.76A 3ndtA-4zu2A:
undetectable		 3ndtA-4zu2A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  62
GLU A 110
PHE A  64
ALA A 112
ASP A  61
 None
 1.25A 3nmuB-4zu2A:
undetectable
3nmuJ-4zu2A:
undetectable		 3nmuB-4zu2A:
22.53
3nmuJ-4zu2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  97
ILE A  20
LEU A  22
SER A  93
ARG A  89
 None
 1.46A 4djfB-4zu2A:
undetectable		 4djfB-4zu2A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 137
LEU A 180
ILE A 157
LEU A 182
PHE A 118
 None
 1.07A 4odrA-4zu2A:
undetectable
4odrB-4zu2A:
undetectable		 4odrA-4zu2A:
18.61
4odrB-4zu2A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 7 SER A  27
GLY A  67
GLY A  68
ALA A  30
ILE A  70
 None
 1.35A 4yjiA-4zu2A:
undetectable		 4yjiA-4zu2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 123
PHE A  64
LEU A  22
GLY A 117
LEU A  94
 None
 1.02A 4zbqA-4zu2A:
2.4		 4zbqA-4zu2A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 123
LEU A   9
PHE A  64
LEU A  22
THR A  21
 None
 1.20A 5hnwB-4zu2A:
undetectable		 5hnwB-4zu2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 114
CYH A  65
ALA A 121
PHE A 118
 None
 0.73A 5xu8A-4zu2A:
undetectable		 5xu8A-4zu2A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  39
GLU A   7
LEU A  11
LEU A  55
 None
 1.22A 6cbzA-4zu2A:
undetectable		 6cbzA-4zu2A:
16.41