SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zud'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASN A  46
ILE A 245
SER A 115
ASN A 111
 None
 1.09A 1h7xA-4zudA:
undetectable		 1h7xA-4zudA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASN A  46
ILE A 245
SER A 115
ASN A 111
 None
 1.08A 1h7xB-4zudA:
undetectable		 1h7xB-4zudA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASN A  46
ILE A 245
SER A 115
ASN A 111
 None
 1.10A 1h7xC-4zudA:
undetectable		 1h7xC-4zudA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASN A  46
ILE A 245
SER A 115
ASN A 111
 None
 1.10A 1h7xD-4zudA:
undetectable		 1h7xD-4zudA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A1073
ARG A1034
ASP A1066
 None
 0.89A 1vptA-4zudA:
undetectable		 1vptA-4zudA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 MET A 243
VAL A 246
LEU A 247
PHE A 251
 None
 1.04A 1x8vA-4zudA:
2.0		 1x8vA-4zudA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ILE A 242
ILE A 241
LEU A  67
ASN A  69
VAL A  49
 None
 1.09A 2nnhB-4zudA:
undetectable		 2nnhB-4zudA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 9 PHE A 117
ALA A 114
TYR A 113
ALA A 159
GLY A 157
 None
 1.09A 2v7bA-4zudA:
undetectable		 2v7bA-4zudA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ALA A1036
ALA A1035
ALA A1040
VAL A1016
ILE A1017
 None
 1.12A 3falA-4zudA:
undetectable		 3falA-4zudA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A  52
ILE A  51
LEU A  78
LEU A  75
 None
 0.82A 4l1wA-4zudA:
undetectable		 4l1wA-4zudA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 246
ASP A  74
SER A 123
PRO A 207
GLY A 203
 None
 1.22A 5syeB-4zudA:
undetectable		 5syeB-4zudA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 5 THR A  88
THR A 287
HIS A 256
GLY A  22
 OLM  A1201 ( 4.6A)
None
None
None
 1.21A 6gbnC-4zudA:
undetectable		 6gbnC-4zudA:
22.38