SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 5 GLU A 795
LEU A 816
ASP A 812
LEU A 809
 None
 1.12A 1n13B-4zuzA:
undetectable
1n13C-4zuzA:
undetectable		 1n13B-4zuzA:
8.18
1n13C-4zuzA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 6 LEU A 616
GLU A 620
THR A  55
TYR A  68
 None
 1.32A 1qvuA-4zuzA:
undetectable		 1qvuA-4zuzA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 11 ARG A 797
LEU A 780
PHE A 777
ALA A 773
GLU A 795
 None
 1.36A 2v0mA-4zuzA:
2.6		 2v0mA-4zuzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 11 LEU A 368
ILE A 408
ALA A 359
GLU A 375
LEU A 178
 None
 1.28A 2v0mA-4zuzA:
2.6		 2v0mA-4zuzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 11 ARG A 797
LEU A 780
PHE A 777
ALA A 773
GLU A 795
 None
 1.31A 2v0mD-4zuzA:
undetectable		 2v0mD-4zuzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 12 ALA A 785
VAL A 788
ILE A 799
PHE A 776
LYS A 778
 None
 1.14A 2v95A-4zuzA:
undetectable		 2v95A-4zuzA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4zuz SIDC
(Legionella
pneumophila) 		3 / 3 LEU A 816
ARG A 797
ILE A 813
 None
 0.67A 2xn5B-4zuzA:
undetectable		 2xn5B-4zuzA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4zuz SIDC
(Legionella
pneumophila) 		3 / 3 CYH A 469
HIS A 470
PHE A 461
 None
 1.14A 3cr4X-4zuzA:
undetectable		 3cr4X-4zuzA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 6 LYS A 678
GLN A 680
LEU A 682
GLU A 683
 None
 0.83A 3h5gB-4zuzA:
undetectable
3h5gC-4zuzA:
undetectable		 3h5gB-4zuzA:
2.95
3h5gC-4zuzA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 11 SER A 613
LEU A 727
ASP A 728
LEU A 617
ILE A 724
 None
 1.21A 3ko0A-4zuzA:
undetectable
3ko0B-4zuzA:
undetectable
3ko0I-4zuzA:
undetectable
3ko0J-4zuzA:
undetectable		 3ko0A-4zuzA:
7.52
3ko0B-4zuzA:
7.52
3ko0I-4zuzA:
7.52
3ko0J-4zuzA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 10 TYR A  20
ILE A  31
TYR A  77
ILE A 113
ILE A 117
 None
 1.17A 3p4wD-4zuzA:
4.8		 3p4wD-4zuzA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 10 TYR A  20
ILE A  31
TYR A  77
ILE A 113
ILE A 117
 None
 1.17A 3p4wE-4zuzA:
4.7		 3p4wE-4zuzA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 8 GLY A 393
PRO A 402
GLN A 426
GLU A 401
 None
 0.87A 3s3mA-4zuzA:
undetectable		 3s3mA-4zuzA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 4 TRP A 324
LEU A 264
LEU A 280
THR A 318
 None
 1.24A 4bboD-4zuzA:
undetectable		 4bboD-4zuzA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 7 GLY A 147
ILE A 133
LEU A 123
PHE A  57
 None
 0.64A 4ejjD-4zuzA:
undetectable		 4ejjD-4zuzA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4zuz SIDC
(Legionella
pneumophila) 		4 / 6 GLN A 334
PRO A 331
PHE A 332
PHE A 394
 None
 0.97A 4fgkA-4zuzA:
undetectable		 4fgkA-4zuzA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 11 HIS A 767
ARG A 797
TYR A 796
CYH A 768
ALA A 773
 None
 1.48A 4ir0A-4zuzA:
undetectable
4ir0B-4zuzA:
undetectable		 4ir0A-4zuzA:
11.06
4ir0B-4zuzA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 11 CYH A 768
ALA A 773
HIS A 767
ARG A 797
TYR A 796
 None
 1.46A 4ir0A-4zuzA:
undetectable
4ir0B-4zuzA:
undetectable		 4ir0A-4zuzA:
11.06
4ir0B-4zuzA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 12 HIS A 767
ARG A 797
TYR A 796
CYH A 768
ALA A 773
 None
 1.48A 4jd1A-4zuzA:
undetectable
4jd1B-4zuzA:
undetectable		 4jd1A-4zuzA:
11.06
4jd1B-4zuzA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 8 TYR A  20
ASP A 618
GLU A  76
ARG A  17
 None
 1.38A 4kr4C-4zuzA:
undetectable		 4kr4C-4zuzA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 8 SER A 154
GLU A 156
THR A 476
ARG A 477
 None
 1.10A 4lnwA-4zuzA:
undetectable		 4lnwA-4zuzA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 6 SER A 154
GLU A 156
THR A 476
ARG A 477
 None
 1.09A 4lnxA-4zuzA:
undetectable		 4lnxA-4zuzA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 11 VAL A 326
LEU A 226
LEU A 264
VAL A 323
TYR A 275
 None
 1.29A 5eb5A-4zuzA:
undetectable		 5eb5A-4zuzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 12 LEU A 628
GLU A 713
GLY A 627
VAL A  51
LEU A 660
 None
 1.33A 5jo9A-4zuzA:
undetectable		 5jo9A-4zuzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 12 LEU A 710
ILE A 699
LEU A 660
LEU A 628
LEU A 692
 None
 1.12A 5nfjB-4zuzA:
undetectable		 5nfjB-4zuzA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 12 LEU A 710
ILE A 699
LEU A 660
LEU A 628
LEU A 692
 None
 1.13A 5nfjC-4zuzA:
undetectable		 5nfjC-4zuzA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 12 LYS A 556
GLN A 572
LEU A 589
LEU A 575
LEU A 540
 None
 1.06A 5nwwA-4zuzA:
undetectable		 5nwwA-4zuzA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 7 TYR A  77
GLN A  73
ASP A  19
HIS A 463
 None
 1.42A 5ov9B-4zuzA:
undetectable		 5ov9B-4zuzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 8 GLY A 627
GLU A 713
ILE A 634
GLN A 135
 None
 1.06A 5vlmD-4zuzA:
undetectable		 5vlmD-4zuzA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 12 SER A 155
ILE A 152
PHE A 450
PHE A 461
LEU A 503
 None
 1.39A 6a93A-4zuzA:
4.0		 6a93A-4zuzA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_C_9F2C302_1
(BETA-LACTAMASE)		 4zuz SIDC
(Legionella
pneumophila) 		5 / 10 GLN A 143
ILE A 141
TYR A 635
THR A 709
ASP A 175
 None
 1.50A 6b5yC-4zuzA:
undetectable
6b5yD-4zuzA:
undetectable		 6b5yC-4zuzA:
6.48
6b5yD-4zuzA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4zuz SIDC
(Legionella
pneumophila) 		4 / 5 GLN A 656
GLU A 702
ASN A 650
TYR A 635
 None
 1.34A 6iftA-4zuzA:
undetectable		 6iftA-4zuzA:
16.32