SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zv1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4zv1 ANCQR
(synthetic
construct) 		5 / 10 LEU A 115
VAL A 122
VAL A 161
GLY A 121
LEU A 112
 None
 1.46A 1fkoA-4zv1A:
undetectable		 1fkoA-4zv1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4zv1 ANCQR
(synthetic
construct) 		4 / 8 TYR A  93
PHE A  94
GLY A  76
PHE A  35
 None
None
ARG  A 301 (-4.5A)
None
 0.73A 1gsfA-4zv1A:
undetectable		 1gsfA-4zv1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4zv1 ANCQR
(synthetic
construct) 		4 / 8 TYR A  93
PHE A  94
GLY A  76
PHE A  35
 None
None
ARG  A 301 (-4.5A)
None
 0.73A 1gsfB-4zv1A:
undetectable		 1gsfB-4zv1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4zv1 ANCQR
(synthetic
construct) 		4 / 8 TYR A  93
PHE A  94
GLY A  76
PHE A  35
 None
None
ARG  A 301 (-4.5A)
None
 0.73A 1gsfC-4zv1A:
undetectable		 1gsfC-4zv1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4zv1 ANCQR
(synthetic
construct) 		4 / 8 TYR A  93
PHE A  94
GLY A  76
PHE A  35
 None
None
ARG  A 301 (-4.5A)
None
 0.73A 1gsfD-4zv1A:
undetectable		 1gsfD-4zv1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4zv1 ANCQR
(synthetic
construct) 		4 / 8 SER A 108
ASN A 106
ILE A 109
ASP A 162
 None
 1.09A 2v57A-4zv1A:
undetectable		 2v57A-4zv1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4zv1 ANCQR
(synthetic
construct) 		4 / 8 SER A 108
ASN A 106
ILE A 109
ASP A 162
 None
 1.09A 2v57C-4zv1A:
undetectable		 2v57C-4zv1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4zv1 ANCQR
(synthetic
construct) 		5 / 9 PHE A  23
PHE A  20
PHE A  94
GLY A  97
PHE A 231
 None
ARG  A 301 (-3.4A)
None
None
None
 1.26A 3t3rB-4zv1A:
undetectable		 3t3rB-4zv1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4zv1 ANCQR
(synthetic
construct) 		5 / 12 ILE A  37
VAL A  51
ILE A  70
LEU A  65
VAL A  87
 None
 1.18A 3w67C-4zv1A:
undetectable		 3w67C-4zv1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4zv1 ANCQR
(synthetic
construct) 		4 / 5 PHE A  23
PHE A  20
LEU A  32
PRO A  55
 None
ARG  A 301 (-3.4A)
None
None
 1.42A 4o8zA-4zv1A:
undetectable		 4o8zA-4zv1A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4zv1 ANCQR
(synthetic
construct) 		4 / 8 ASP A 167
PHE A 149
VAL A 101
ILE A 185
 ARG  A 301 (-2.9A)
None
None
None
 0.84A 5hw8H-4zv1A:
undetectable		 5hw8H-4zv1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4zv1 ANCQR
(synthetic
construct) 		5 / 12 LYS A  45
LYS A  46
GLU A 208
LEU A 206
GLU A 205
 None
 1.22A 5nwuA-4zv1A:
undetectable		 5nwuA-4zv1A:
11.52