SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		4 / 5 THR A  59
GLU A 131
THR A 133
HIS A 145
 None
 1.35A 1d4fB-4zv3A:
undetectable		 1d4fB-4zv3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		3 / 3 ALA A 162
VAL A 142
TRP A 165
 None
 1.02A 1gmkA-4zv3A:
undetectable
1gmkB-4zv3A:
undetectable		 1gmkA-4zv3A:
3.73
1gmkB-4zv3A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 9 LEU A 234
VAL A 312
ILE A 310
TYR A 336
ILE A 274
 None
 1.10A 1q6iA-4zv3A:
undetectable		 1q6iA-4zv3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 10 LEU A 234
VAL A 312
ILE A 310
TYR A 336
ILE A 274
 None
 1.24A 1q6iB-4zv3A:
undetectable		 1q6iB-4zv3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 12 VAL A 312
VAL A  75
PHE A 116
ASN A 160
TYR A 336
 None
 1.39A 2y00A-4zv3A:
undetectable		 2y00A-4zv3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 12 VAL A 312
VAL A  75
PHE A 116
ASN A 160
TYR A 336
 None
 1.42A 2y01B-4zv3A:
undetectable		 2y01B-4zv3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		3 / 3 LYS A  82
VAL A 253
HIS A 250
 None
 0.64A 3tj7A-4zv3A:
undetectable		 3tj7A-4zv3A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 12 GLY A  88
ILE A  90
ILE A  91
VAL A 142
ILE A 132
 None
 0.94A 4ax8A-4zv3A:
undetectable		 4ax8A-4zv3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 12 GLY A  88
ILE A  90
ILE A  91
VAL A 142
ILE A 132
 None
 0.91A 4azvA-4zv3A:
undetectable		 4azvA-4zv3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 10 GLY A 298
ALA A 332
VAL A 312
GLU A 311
VAL A 261
 None
 1.12A 4da7A-4zv3A:
undetectable		 4da7A-4zv3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		4 / 4 ILE A  80
ASP A 259
ARG A  62
THR A 276
 None
 1.47A 4nx6A-4zv3A:
undetectable		 4nx6A-4zv3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		4 / 4 ILE A  80
ASP A 259
ARG A  62
THR A 276
 None
 1.47A 4nx7A-4zv3A:
undetectable		 4nx7A-4zv3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		4 / 5 VAL A 111
THR A 114
ASN A 160
LEU A  81
 None
 1.30A 5m0iB-4zv3A:
undetectable		 5m0iB-4zv3A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Mus
musculus) 		5 / 12 GLY A 251
VAL A 146
GLY A  78
PHE A 334
VAL A 279
 COA  A 401 ( 3.8A)
None
None
None
None
 0.93A 5tuiB-4zv3A:
undetectable		 5tuiB-4zv3A:
21.81