SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  87
ASP A  51
ILE A  50
PHE A  47
ALA A  31
 None
GDP  A 501 ( 4.6A)
None
None
None
 1.38A 1oltA-4zv4A:
undetectable		 1oltA-4zv4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 134
LEU A 199
VAL A 196
ALA A  30
HIS A  79
 None
 1.28A 1q23A-4zv4A:
undetectable
1q23B-4zv4A:
undetectable		 1q23A-4zv4A:
18.29
1q23B-4zv4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  87
GLY A  16
ILE A 103
THR A 116
 None
 0.79A 1t7iB-4zv4A:
undetectable		 1t7iB-4zv4A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  87
GLY A  16
ILE A 103
THR A 116
 None
 0.75A 1t7jB-4zv4A:
undetectable		 1t7jB-4zv4A:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HCJ_B_TACB888_1
(PROTEIN CHAIN
ELONGATION FACTOR
EF-TU)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 4 THR A  26
SER A  66
ASP A  81
PRO A  83
 MG  A 502 ( 3.1A)
None
MG  A 502 (-3.7A)
MG  A 502 ( 4.1A)
 0.85A 2hcjA-4zv4A:
0.0
2hcjB-4zv4A:
42.4		 2hcjA-4zv4A:
64.44
2hcjB-4zv4A:
84.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 5 THR A  26
SER A  66
ASP A  81
PRO A  83
 MG  A 502 ( 3.1A)
None
MG  A 502 (-3.7A)
MG  A 502 ( 4.1A)
 0.54A 2hdnA-4zv4A:
undetectable
2hdnB-4zv4A:
42.2
2hdnD-4zv4A:
19.8		 2hdnA-4zv4A:
64.44
2hdnB-4zv4A:
84.41
2hdnD-4zv4A:
84.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 5 THR A  26
SER A  66
ASP A  81
PRO A  83
 MG  A 502 ( 3.1A)
None
MG  A 502 (-3.7A)
MG  A 502 ( 4.1A)
 0.54A 2hdnB-4zv4A:
42.2
2hdnC-4zv4A:
undetectable
2hdnD-4zv4A:
19.8		 2hdnB-4zv4A:
84.41
2hdnC-4zv4A:
64.44
2hdnD-4zv4A:
84.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 7 THR A  26
SER A  66
ASP A  81
PRO A  83
 MG  A 502 ( 3.1A)
None
MG  A 502 (-3.7A)
MG  A 502 ( 4.1A)
 0.56A 2hdnE-4zv4A:
undetectable
2hdnF-4zv4A:
41.6
2hdnH-4zv4A:
41.7		 2hdnE-4zv4A:
64.44
2hdnF-4zv4A:
84.41
2hdnH-4zv4A:
84.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 7 THR A  26
SER A  66
ASP A  81
PRO A  83
 MG  A 502 ( 3.1A)
None
MG  A 502 (-3.7A)
MG  A 502 ( 4.1A)
 0.56A 2hdnF-4zv4A:
41.6
2hdnG-4zv4A:
undetectable
2hdnH-4zv4A:
41.7		 2hdnF-4zv4A:
84.41
2hdnG-4zv4A:
64.44
2hdnH-4zv4A:
84.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 6 THR A  26
SER A  66
ASP A  81
PRO A  83
 MG  A 502 ( 3.1A)
None
MG  A 502 (-3.7A)
MG  A 502 ( 4.1A)
 0.55A 2hdnI-4zv4A:
undetectable
2hdnJ-4zv4A:
41.8
2hdnL-4zv4A:
41.7		 2hdnI-4zv4A:
64.44
2hdnJ-4zv4A:
84.41
2hdnL-4zv4A:
84.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 6 THR A  26
SER A  66
ASP A  81
PRO A  83
 MG  A 502 ( 3.1A)
None
MG  A 502 (-3.7A)
MG  A 502 ( 4.1A)
 0.56A 2hdnJ-4zv4A:
41.8
2hdnK-4zv4A:
undetectable
2hdnL-4zv4A:
41.7		 2hdnJ-4zv4A:
84.41
2hdnK-4zv4A:
64.44
2hdnL-4zv4A:
84.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 326
TYR A 330
VAL A 387
VAL A 312
 None
 1.17A 2zawA-4zv4A:
undetectable		 2zawA-4zv4A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 388
ALA A 389
GLY A  60
VAL A  89
ILE A  93
 None
 0.86A 3cyxA-4zv4A:
undetectable		 3cyxA-4zv4A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 5 ALA A  30
ALA A  78
TYR A  77
MET A  99
 None
 1.25A 3d91A-4zv4A:
undetectable		 3d91A-4zv4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 104
ASP A 162
GLY A 127
VAL A 126
ILE A 131
 None
 1.00A 3oxxD-4zv4A:
undetectable		 3oxxD-4zv4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  41
TYR A  70
ALA A  44
SER A  37
 None
 0.83A 3u9hA-4zv4A:
undetectable		 3u9hA-4zv4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  41
TYR A  70
ALA A  44
SER A  37
 None
 0.84A 3u9hB-4zv4A:
undetectable		 3u9hB-4zv4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		3 / 3 THR A  65
ASN A  91
GLU A  56
 None
 0.76A 3v4tA-4zv4A:
undetectable
3v4tC-4zv4A:
undetectable		 3v4tA-4zv4A:
22.66
3v4tC-4zv4A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  41
TYR A  70
ALA A  44
SER A  37
 None
 0.86A 4bjcA-4zv4A:
undetectable		 4bjcA-4zv4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 315
THR A 386
THR A  94
GLY A 390
 None
 0.94A 4eqlA-4zv4A:
1.4		 4eqlA-4zv4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  41
TYR A  70
ALA A  44
SER A  37
 None
 0.78A 4hyfA-4zv4A:
undetectable		 4hyfA-4zv4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  41
TYR A  70
ALA A  44
SER A  37
 None
 0.79A 4hyfB-4zv4A:
undetectable		 4hyfB-4zv4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  41
TYR A  70
ALA A  44
SER A  37
 None
 0.83A 4hyfC-4zv4A:
undetectable		 4hyfC-4zv4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 315
THR A 386
THR A  94
GLY A 390
 None
 0.92A 4l39B-4zv4A:
1.1		 4l39B-4zv4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 136
ASP A 110
THR A  17
VAL A 105
 GDP  A 501 (-3.6A)
None
None
None
 0.98A 4yoaA-4zv4A:
1.9		 4yoaA-4zv4A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 297
ARG A 237
ALA A 371
GLU A 373
 None
 1.18A 5a06C-4zv4A:
5.6
5a06D-4zv4A:
2.9		 5a06C-4zv4A:
23.64
5a06D-4zv4A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.13A 5n0oA-4zv4A:
2.1		 5n0oA-4zv4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.13A 5n0oB-4zv4A:
undetectable		 5n0oB-4zv4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
GLY A  19
HIS A  23
ALA A 102
VAL A  80
 None
 1.20A 5n0rA-4zv4A:
undetectable		 5n0rA-4zv4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.15A 5n0rA-4zv4A:
undetectable		 5n0rA-4zv4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
GLY A  19
HIS A  23
ALA A 102
VAL A  80
 None
 1.19A 5n0wA-4zv4A:
2.1		 5n0wA-4zv4A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.13A 5n0wA-4zv4A:
2.1		 5n0wA-4zv4A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
GLY A  19
HIS A  23
ALA A 102
VAL A  80
 None
 1.21A 5n0xB-4zv4A:
2.1		 5n0xB-4zv4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zv4 ELONGATION FACTOR TU
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  18
TYR A  88
HIS A  23
ALA A 102
VAL A  80
 None
 1.14A 5n0xB-4zv4A:
2.1		 5n0xB-4zv4A:
23.76