SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4zv6 ALPHAREP-7
(synthetic
construct) 		3 / 3 ASP A 120
ARG A 122
ASP A  89
 None
 0.95A 1vptA-4zv6A:
undetectable		 1vptA-4zv6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 THR A 250
LEU A 224
ILE A 237
MET A 267
TYR A 285
 None
 1.13A 3gwxA-4zv6A:
undetectable		 3gwxA-4zv6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 11 ALA A 130
ILE A 134
GLY A 104
LEU A 112
ALA A 108
 None
 1.28A 3kw2A-4zv6A:
undetectable		 3kw2A-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 11 ALA A 192
ILE A 196
GLY A 166
LEU A 174
ALA A 170
 None
 1.26A 3kw2A-4zv6A:
undetectable		 3kw2A-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 11 ALA A 223
ILE A 227
GLY A 197
LEU A 205
ALA A 201
 None
 1.22A 3kw2A-4zv6A:
undetectable		 3kw2A-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 11 ALA A 192
ILE A 196
GLY A 166
LEU A 174
ALA A 170
 None
 1.28A 3kw2B-4zv6A:
undetectable		 3kw2B-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 11 ALA A 223
ILE A 227
GLY A 197
LEU A 205
ALA A 201
 None
 1.24A 3kw2B-4zv6A:
undetectable		 3kw2B-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 11 ALA A 254
ILE A 258
GLY A 228
LEU A 236
ALA A 232
 None
 1.24A 3kw2B-4zv6A:
undetectable		 3kw2B-4zv6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLY A 132
GLY A 135
VAL A 140
ALA A 158
ALA A 157
 None
 1.03A 3mteA-4zv6A:
undetectable		 3mteA-4zv6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLY A 163
GLY A 166
VAL A 171
ALA A 189
ALA A 188
 None
 1.00A 3mteA-4zv6A:
undetectable		 3mteA-4zv6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLY A 194
GLY A 197
VAL A 202
ALA A 220
ALA A 219
 None
 0.93A 3mteA-4zv6A:
undetectable		 3mteA-4zv6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLY A 194
GLY A 197
VAL A 202
ALA A 220
ALA A 219
 None
 1.02A 3p2kC-4zv6A:
undetectable		 3p2kC-4zv6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLY A 132
GLY A 135
VAL A 140
ALA A 158
ALA A 157
 None
 1.05A 3p2kD-4zv6A:
undetectable		 3p2kD-4zv6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLY A 163
GLY A 166
VAL A 171
ALA A 189
ALA A 188
 None
 1.00A 3p2kD-4zv6A:
undetectable		 3p2kD-4zv6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLY A 194
GLY A 197
VAL A 202
ALA A 220
ALA A 219
 None
 0.91A 3p2kD-4zv6A:
undetectable		 3p2kD-4zv6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4zv6 ALPHAREP-7
(synthetic
construct) 		3 / 3 TYR A 160
LEU A 100
LYS A 102
 None
 0.73A 3sueD-4zv6A:
undetectable		 3sueD-4zv6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4zv6 ALPHAREP-7
(synthetic
construct) 		3 / 3 ASP A 120
ARG A 122
ASP A  89
 None
 0.78A 4fp9D-4zv6A:
undetectable		 4fp9D-4zv6A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4zv6 ALPHAREP-7
(synthetic
construct) 		3 / 3 ASP A 120
ARG A 122
ASP A  89
 None
 0.88A 4fzvA-4zv6A:
undetectable		 4fzvA-4zv6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLU A  75
LEU A  81
GLY A  73
LEU A  50
ALA A  65
 None
 1.31A 5kbwA-4zv6A:
undetectable		 5kbwA-4zv6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLU A 168
LEU A 174
GLY A 166
LEU A 143
ALA A 158
 None
 1.19A 5kbwA-4zv6A:
undetectable		 5kbwA-4zv6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4zv6 ALPHAREP-7
(synthetic
construct) 		5 / 12 GLU A 168
LEU A 174
GLY A 166
LEU A 143
ALA A 158
 None
 1.20A 5kc4E-4zv6A:
undetectable		 5kc4E-4zv6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4zv6 ALPHAREP-7
(synthetic
construct) 		4 / 8 GLY A  39
LEU A  38
ALA A  46
GLU A  44
 None
 0.70A 6mdqA-4zv6A:
undetectable		 6mdqA-4zv6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4zv6 ALPHAREP-7
(synthetic
construct) 		4 / 8 GLY A 194
LEU A 193
ALA A 201
GLU A 199
 None
 0.80A 6mdqA-4zv6A:
undetectable		 6mdqA-4zv6A:
15.66