SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 6 LYS A  90
LEU A  88
THR A  98
LEU A 129
 None
 1.08A 1etb2-4zv9A:
undetectable		 1etb2-4zv9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		3 / 3 ASN A 268
ALA A 279
ASN A  -1
 None
 0.82A 1n4fA-4zv9A:
undetectable		 1n4fA-4zv9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 7 LYS A  90
LEU A  88
THR A  98
LEU A 129
 None
 1.00A 1tyrB-4zv9A:
undetectable		 1tyrB-4zv9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 7 ALA A 278
ALA A 282
THR A 286
LEU A 226
 None
 0.91A 2wx2A-4zv9A:
undetectable		 2wx2A-4zv9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 109
GLY A 133
VAL A 104
LEU A 150
SER A 136
 None
 0.90A 3mteA-4zv9A:
2.9		 3mteA-4zv9A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 109
GLY A 133
VAL A 104
LEU A 150
SER A 136
 None
 0.97A 3p2kD-4zv9A:
undetectable		 3p2kD-4zv9A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 8 GLY A  80
ALA A 165
SER A  77
GLU A 168
 None
GOL  A 302 (-3.5A)
GOL  A 302 ( 4.6A)
GOL  A 302 (-2.8A)
 0.90A 3u9hA-4zv9A:
undetectable		 3u9hA-4zv9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 8 GLY A  80
ALA A 165
SER A  77
GLU A 168
 None
GOL  A 302 (-3.5A)
GOL  A 302 ( 4.6A)
GOL  A 302 (-2.8A)
 0.89A 3u9hB-4zv9A:
undetectable		 3u9hB-4zv9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 6 GLU A  71
ILE A  73
PHE A  69
TYR A 173
 None
 1.24A 4a97I-4zv9A:
undetectable		 4a97I-4zv9A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 8 GLY A  80
ALA A 165
SER A  77
GLU A 168
 None
GOL  A 302 (-3.5A)
GOL  A 302 ( 4.6A)
GOL  A 302 (-2.8A)
 0.85A 4bjcA-4zv9A:
undetectable		 4bjcA-4zv9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 8 TRP A 240
GLU A 255
GLU A 244
LYS A 248
 None
 1.19A 4bqfB-4zv9A:
4.9		 4bqfB-4zv9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 6 GLU A 106
ILE A 114
ASN A 111
VAL A 154
 CME  A 186 ( 4.8A)
None
None
None
 1.07A 4ejwB-4zv9A:
undetectable		 4ejwB-4zv9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 VAL A 121
ALA A 122
PHE A 290
GLY A 125
THR A 183
 None
 1.30A 4mm4A-4zv9A:
undetectable		 4mm4A-4zv9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 210
ASN A 237
TRP A 240
ALA A 196
ALA A 213
 CME  A 186 ( 3.4A)
None
None
None
None
 1.12A 4uckB-4zv9A:
undetectable		 4uckB-4zv9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		4 / 7 LYS A  90
LEU A  88
THR A  98
LEU A 129
 None
 1.04A 5bojB-4zv9A:
undetectable		 5bojB-4zv9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		6 / 12 ALA A 278
HIS A 267
LEU A 281
ALA A 282
THR A 286
PHE A 208
 None
 1.42A 5k9dA-4zv9A:
undetectable		 5k9dA-4zv9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4zv9 UNCHARACTERIZED
PROTEIN
(Escherichia
coli) 		6 / 12 ALA A 278
LEU A 281
ALA A 282
THR A 286
PHE A 208
TYR A 209
 None
None
None
None
None
CME  A 186 ( 4.8A)
 1.48A 5k9dA-4zv9A:
undetectable		 5k9dA-4zv9A:
20.42