SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zve DIGUANYLATE CYCLASE
DOSC
(Escherichia
coli) 		4 / 8 GLY A 411
ALA A 408
THR A 348
ILE A 340
 None
 0.84A 3jusA-4zveA:
undetectable		 3jusA-4zveA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zve DIGUANYLATE CYCLASE
DOSC
(Escherichia
coli) 		4 / 8 GLY A 411
ALA A 408
THR A 348
ILE A 340
 None
 0.84A 3jusA-4zveA:
undetectable		 3jusA-4zveA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4zve DIGUANYLATE CYCLASE
DOSC
(Escherichia
coli) 		4 / 5 ILE A 420
ARG A 450
ASP A 376
VAL A 370
 None
CIT  A 501 ( 3.2A)
CIT  A 501 (-3.6A)
None
 1.27A 4nkxD-4zveA:
undetectable		 4nkxD-4zveA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4zve DIGUANYLATE CYCLASE
DOSC
(Escherichia
coli) 		5 / 9 VAL A 401
ILE A 420
LEU A 418
ILE A 332
ILE A 380
 None
 0.86A 5nunA-4zveA:
undetectable		 5nunA-4zveA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4zve DIGUANYLATE CYCLASE
DOSC
(Escherichia
coli) 		5 / 11 GLY A 421
ALA A 422
ALA A 441
ILE A 444
ARG A 452
 None
None
None
None
EDO  A 502 ( 3.9A)
 1.08A 5yk2A-4zveA:
undetectable		 5yk2A-4zveA:
17.86