SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 9 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ALA A  90
ILE A  94
THR A 165
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.40A 1aj6A-4zviA:
31.5		 1aj6A-4zviA:
99.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 12 ASP A  49
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
ARG A 136
THR A 165
 None
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.59A 1kijA-4zviA:
42.3		 1kijA-4zviA:
45.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.48A 1kijB-4zviA:
42.4		 1kijB-4zviA:
45.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 ALA A 287
VAL A 349
GLY A 284
ALA A 321
ILE A 222
 None
 1.22A 1kxhA-4zviA:
undetectable		 1kxhA-4zviA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  46
ASP A  49
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
None
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.61A 1s14A-4zviA:
25.4		 1s14A-4zviA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  46
ASP A  49
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ALA A  90
ILE A  94
ARG A 136
 4S4  A 401 (-4.3A)
None
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.5A)
None
None
None
 0.69A 1s14B-4zviA:
27.5		 1s14B-4zviA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 1.16A 2eimJ-4zviA:
undetectable		 2eimJ-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 1.21A 2eimW-4zviA:
undetectable		 2eimW-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 PHE A 225
ALA A 224
GLY A 221
TYR A 218
 None
 1.20A 3bcrA-4zviA:
undetectable		 3bcrA-4zviA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		3 / 3 PRO A 153
LEU A 154
GLN A 143
 None
 0.60A 3hznG-4zviA:
undetectable
3hznH-4zviA:
undetectable		 3hznG-4zviA:
21.01
3hznH-4zviA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 GLN A 275
PRO A 330
SER A 342
VAL A 345
VAL A 325
 None
IOD  A 402 (-4.7A)
None
None
None
 1.22A 3iw1A-4zviA:
undetectable		 3iw1A-4zviA:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  46
ASP A  49
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
None
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.64A 3lpsA-4zviA:
39.6		 3lpsA-4zviA:
38.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 7 ASN A 265
ILE A 266
PHE A 285
MET A 289
 None
 1.20A 3tvxB-4zviA:
undetectable		 3tvxB-4zviA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 8 TYR A 360
HIS A 237
VAL A 372
ILE A 375
LEU A 319
 None
 1.17A 4jq1B-4zviA:
undetectable		 4jq1B-4zviA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 9 TYR A 360
HIS A 237
VAL A 372
ILE A 375
LEU A 319
 None
 1.19A 4jqaA-4zviA:
undetectable		 4jqaA-4zviA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 9 TYR A 360
HIS A 237
VAL A 372
ILE A 375
LEU A 319
 None
 1.15A 4jqaB-4zviA:
1.3		 4jqaB-4zviA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 10 TYR A 360
HIS A 237
VAL A 372
ILE A 375
LEU A 319
 None
 1.15A 4jtqA-4zviA:
undetectable		 4jtqA-4zviA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 9 TYR A 360
HIS A 237
VAL A 372
ILE A 375
LEU A 319
 None
 1.15A 4jtqB-4zviA:
1.0		 4jtqB-4zviA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 7 ARG A 204
PHE A 216
SER A 202
HIS A 217
 None
 1.08A 4o4dA-4zviA:
undetectable		 4o4dA-4zviA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 11 ASN A  46
ASP A  49
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
None
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.58A 4urnA-4zviA:
30.1		 4urnA-4zviA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 11 ASN A  46
ASP A  49
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
None
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.43A 4urnB-4zviA:
27.7		 4urnB-4zviA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 11 ASN A  46
ASP A  49
GLU A  50
ASP A  73
ARG A  76
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
None
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.45A 4urnC-4zviA:
29.7		 4urnC-4zviA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		8 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
ARG A 136
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
 0.44A 4uroA-4zviA:
30.6		 4uroA-4zviA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		8 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
ARG A 136
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
 0.47A 4uroB-4zviA:
30.9		 4uroB-4zviA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ALA A  90
ILE A  94
ARG A 136
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
None
 0.48A 4uroC-4zviA:
30.8		 4uroC-4zviA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		9 / 12 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.44A 4uroD-4zviA:
30.0		 4uroD-4zviA:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 11 VAL A  69
VAL A  61
VAL A  71
PHE A  41
LEU A 187
 None
None
4S4  A 401 ( 4.9A)
None
None
 1.08A 5e4dB-4zviA:
undetectable		 5e4dB-4zviA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 GLU A 253
GLY A 220
SER A 199
GLY A 200
 None
 1.14A 5kprA-4zviA:
undetectable		 5kprA-4zviA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 1.06A 5w97J-4zviA:
undetectable		 5w97J-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 1.05A 5wauJ-4zviA:
undetectable		 5wauJ-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 7 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 1.01A 5xdqA-4zviA:
undetectable
5xdqJ-4zviA:
undetectable		 5xdqA-4zviA:
20.00
5xdqJ-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 0.95A 5z86J-4zviA:
undetectable		 5z86J-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 6 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 0.96A 5z86N-4zviA:
undetectable
5z86W-4zviA:
undetectable		 5z86N-4zviA:
20.00
5z86W-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 6 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 0.98A 5zcoN-4zviA:
undetectable
5zcoW-4zviA:
undetectable		 5zcoN-4zviA:
20.00
5zcoW-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 VAL A 123
LEU A 191
PHE A 182
LEU A 187
ARG A 190
 None
 1.17A 6ew0G-4zviA:
undetectable		 6ew0G-4zviA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zvi DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 ARG A 286
MET A 289
THR A 290
LEU A 293
 None
 0.72A 6nknW-4zviA:
undetectable		 6nknW-4zviA:
10.18