SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 ILE A 413
ASP A 218
ALA A 389
GLY A 211
TYR A 419
 None
 1.14A 1kiaB-4zweA:
undetectable		 1kiaB-4zweA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 ILE A 413
ASP A 218
ALA A 389
GLY A 211
TYR A 419
 None
 1.14A 1kiaC-4zweA:
undetectable		 1kiaC-4zweA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 4 LEU A 182
VAL A 340
CYH A 341
ALA A 529
 None
 1.25A 1mz9E-4zweA:
undetectable		 1mz9E-4zweA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		3 / 3 LEU A 476
PRO A 477
ARG A 470
 None
 0.58A 2qd4B-4zweA:
undetectable		 2qd4B-4zweA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		3 / 3 LEU A 476
PRO A 477
ARG A 470
 None
 0.49A 2qd5A-4zweA:
undetectable		 2qd5A-4zweA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 LEU A 132
ILE A 136
LEU A 128
VAL A 196
PHE A 141
 None
 1.24A 2qo6A-4zweA:
undetectable		 2qo6A-4zweA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 ILE A 222
ARG A 164
PHE A 217
ILE A 426
LEU A 422
 None
DGT  A 701 (-3.3A)
None
None
None
 1.09A 2w3bA-4zweA:
undetectable		 2w3bA-4zweA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 ASP A 311
HIS A 210
ASP A 218
HIS A 215
 DGT  A 701 (-2.4A)
DGT  A 701 (-4.5A)
None
DGT  A 701 (-3.6A)
 1.05A 3c0zC-4zweA:
undetectable		 3c0zC-4zweA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.18A 3galA-4zweA:
undetectable		 3galA-4zweA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.16A 3galB-4zweA:
undetectable		 3galB-4zweA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 LEU A 132
GLY A 176
ILE A 136
LEU A 169
ARG A 318
 None
 1.32A 3gyqA-4zweA:
undetectable
3gyqB-4zweA:
undetectable		 3gyqA-4zweA:
18.29
3gyqB-4zweA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 8 ASP A 311
SER A 302
ASP A 506
TYR A 374
 DGT  A 701 (-2.4A)
None
None
DGT  A 701 (-3.5A)
 1.14A 3havA-4zweA:
undetectable		 3havA-4zweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 210
HIS A 233
HIS A 215
ASP A 311
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.8A)
DGT  A 701 (-3.6A)
DGT  A 701 (-2.4A)
 1.13A 3nvcA-4zweA:
undetectable		 3nvcA-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 6 HIS A 233
HIS A 215
HIS A 210
ASP A 311
 DGT  A 701 (-3.8A)
DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
DGT  A 701 (-2.4A)
 0.90A 3nvcA-4zweA:
undetectable		 3nvcA-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 5 LEU A 150
GLY A 151
PHE A 157
ASN A 380
 None
None
DGT  A 702 (-3.5A)
None
 1.06A 3uq6B-4zweA:
undetectable		 3uq6B-4zweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 5 LEU A 150
GLY A 152
PHE A 157
ASN A 380
 None
None
DGT  A 702 (-3.5A)
None
 1.29A 3uq6B-4zweA:
undetectable		 3uq6B-4zweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 ILE A 191
GLU A 270
TYR A 298
VAL A 179
PHE A 267
 None
 1.43A 4a97A-4zweA:
2.1
4a97B-4zweA:
1.7		 4a97A-4zweA:
20.23
4a97B-4zweA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 7 LEU A 150
TYR A 315
ASP A 319
HIS A 370
 None
DGT  A 701 (-3.6A)
DGT  A 701 (-3.2A)
DGT  A 701 (-4.6A)
 1.30A 4arcA-4zweA:
undetectable		 4arcA-4zweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 7 SER A 214
ARG A 164
GLU A 234
ASP A 218
 None
DGT  A 701 (-3.3A)
None
None
 1.06A 4d33B-4zweA:
undetectable		 4d33B-4zweA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		3 / 3 TYR A 315
ARG A 164
HIS A 215
 DGT  A 701 (-3.6A)
DGT  A 701 (-3.3A)
DGT  A 701 (-3.6A)
 1.16A 4fubA-4zweA:
undetectable		 4fubA-4zweA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 5 GLY A 124
ASP A 120
GLU A 127
VAL A 133
 None
 0.87A 4nkvD-4zweA:
undetectable		 4nkvD-4zweA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 HIS A 215
HIS A 210
GLY A 211
PHE A 217
GLY A 219
 DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
None
None
None
 1.20A 4qa0A-4zweA:
undetectable		 4qa0A-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 HIS A 215
HIS A 210
GLY A 211
PHE A 217
GLY A 219
 DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
None
None
None
 1.12A 4qa2A-4zweA:
undetectable		 4qa2A-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 HIS A 215
HIS A 210
GLY A 211
PHE A 217
GLY A 219
 DGT  A 701 (-3.6A)
DGT  A 701 (-4.5A)
None
None
None
 1.13A 4qa2B-4zweA:
undetectable		 4qa2B-4zweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 12 VAL A 156
GLY A 151
TYR A 154
ILE A 147
ASN A 163
 DGT  A 703 ( 3.6A)
None
None
None
None
 1.42A 4xueB-4zweA:
undetectable		 4xueB-4zweA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 7 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.13A 6b8kA-4zweA:
undetectable		 6b8kA-4zweA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		4 / 8 HIS A 210
ASN A 207
ARG A 206
GLU A 234
 DGT  A 701 (-4.5A)
DGT  A 701 (-3.6A)
DGT  A 701 ( 4.2A)
None
 1.13A 6b94A-4zweA:
undetectable		 6b94A-4zweA:
8.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		5 / 5 SER A 192
ARG A 194
ASP A 195
ARG A 290
LYS A 294
 None
 0.26A 6dwdA-4zweA:
56.0		 6dwdA-4zweA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		3 / 3 ARG A 305
HIS A 517
ARG A 531
 None
 0.67A 6dwdD-4zweA:
57.7		 6dwdD-4zweA:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens) 		3 / 3 HIS A 123
ARG A 318
ILE A 122
 None
 0.87A 6fgdA-4zweA:
undetectable		 6fgdA-4zweA:
20.90