SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 7 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.89A 1gtiA-4zwjA:
undetectable		 1gtiA-4zwjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 6 THR A 229
LEU A 226
GLY A 224
TYR A 136
 None
 1.07A 1gtiC-4zwjA:
undetectable		 1gtiC-4zwjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifA-4zwjA:
undetectable		 1kifA-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifB-4zwjA:
undetectable		 1kifB-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifC-4zwjA:
undetectable		 1kifC-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifD-4zwjA:
undetectable		 1kifD-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifE-4zwjA:
undetectable		 1kifE-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifF-4zwjA:
undetectable		 1kifF-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifG-4zwjA:
undetectable		 1kifG-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifH-4zwjA:
undetectable		 1kifH-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 LEU A2047
VAL A2045
TYR A2026
THR A2116
 None
 0.88A 1nw3A-4zwjA:
undetectable		 1nw3A-4zwjA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 12 ASP A2043
LEU A2108
ILE A2025
ILE A2175
PHE A2119
 None
 0.97A 1pbkA-4zwjA:
undetectable		 1pbkA-4zwjA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 7 PHE A  13
TYR A  30
LEU A  31
THR A   4
 None
 1.25A 1rmtB-4zwjA:
undetectable		 1rmtB-4zwjA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1ve9A-4zwjA:
undetectable		 1ve9A-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		3 / 3 LYS A2164
ASP A2072
CYH A 316
 None
 1.07A 2br4F-4zwjA:
undetectable		 2br4F-4zwjA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.25A 2du8G-4zwjA:
undetectable		 2du8G-4zwjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 5 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.15A 2du8J-4zwjA:
undetectable		 2du8J-4zwjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 4 LEU A1033
ILE A1058
ILE A1050
ALA A1049
 None
 0.84A 2i30A-4zwjA:
2.1		 2i30A-4zwjA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.09A 2xytE-4zwjA:
1.9		 2xytE-4zwjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.03A 2xytH-4zwjA:
undetectable		 2xytH-4zwjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 7 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.08A 2xytI-4zwjA:
undetectable		 2xytI-4zwjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 8 VAL A2249
GLY A2323
PRO A2128
LYS A 141
 None
 0.96A 3bjwA-4zwjA:
1.8		 3bjwA-4zwjA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 12 VAL A 227
ALA A 233
ALA A 234
GLN A 237
VAL A 254
 None
 0.77A 3fc6C-4zwjA:
2.1		 3fc6C-4zwjA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 10 ASP A2043
LEU A2108
ILE A2025
ILE A2175
PHE A2119
 None
 1.03A 3kz7A-4zwjA:
undetectable		 3kz7A-4zwjA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 6 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.24A 3peoG-4zwjA:
2.0		 3peoG-4zwjA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 8 PHE A 261
ALA A 298
ASN A 302
ALA A 124
 None
 0.80A 3t3sD-4zwjA:
undetectable		 3t3sD-4zwjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 8 PHE A 261
ALA A 298
ASN A 302
ALA A 124
 None
 0.67A 3t3sF-4zwjA:
1.3		 3t3sF-4zwjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 6 SER A 127
LEU A 125
HIS A 211
THR A 160
 None
 1.49A 3thrB-4zwjA:
undetectable		 3thrB-4zwjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 7 ALA A 124
TRP A 265
MET A  86
ALA A  82
 None
 1.32A 3tx2A-4zwjA:
undetectable		 3tx2A-4zwjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 6 ARG A 135
ASP A  83
GLU A 122
LEU A 131
 None
 1.36A 4ax8A-4zwjA:
undetectable		 4ax8A-4zwjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 8 VAL A 130
TYR A 223
CYH A 222
ILE A 218
 None
 1.31A 4bqtC-4zwjA:
2.0
4bqtD-4zwjA:
undetectable		 4bqtC-4zwjA:
13.67
4bqtD-4zwjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 7 TYR A  30
TYR A  26
GLU A  25
PHE A   9
 None
 1.17A 5aclA-4zwjA:
undetectable		 5aclA-4zwjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		5 / 12 GLY A1028
ILE A1058
LEU A1032
LYS A1065
LEU A1066
 None
 1.15A 5bw4A-4zwjA:
undetectable		 5bw4A-4zwjA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 11 ASP A2043
LEU A2108
ILE A2025
ILE A2175
PHE A2119
 None
 1.13A 5d75A-4zwjA:
undetectable		 5d75A-4zwjA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 7 VAL A2326
THR A2311
LEU A2133
VAL A2146
 None
 0.97A 5e4dA-4zwjA:
undetectable
5e4dB-4zwjA:
undetectable		 5e4dA-4zwjA:
13.24
5e4dB-4zwjA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 11 ASP A2043
LEU A2108
ILE A2025
ILE A2175
PHE A2119
 None
 1.11A 5gpgA-4zwjA:
undetectable		 5gpgA-4zwjA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 6 VAL A 157
SER A 127
ARG A 135
ILE A 133
 None
 0.98A 5jw1B-4zwjA:
undetectable		 5jw1B-4zwjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		4 / 8 LEU A  47
ILE A 286
THR A 289
GLN A  36
 None
 1.06A 5ljbA-4zwjA:
undetectable		 5ljbA-4zwjA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		4 / 8 PRO A  53
ILE A  48
VAL A  87
ILE A 300
 None
 0.85A 5mzrE-4zwjA:
3.6		 5mzrE-4zwjA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 12 GLN A2188
LEU A2210
ARG A2355
PRO A2182
ILE A2214
 None
 1.41A 5uhbC-4zwjA:
1.5		 5uhbC-4zwjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		3 / 3 ASP A2114
ASN A2115
ASP A2049
 None
 0.82A 5vopA-4zwjA:
undetectable		 5vopA-4zwjA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		3 / 3 ASP A2114
ASN A2115
ASP A2049
 None
 0.82A 5vopB-4zwjA:
undetectable		 5vopB-4zwjA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Homo
sapiens;
Mus
musculus;
Escherichia
virus
T4) 		5 / 12 GLY A2298
VAL A2150
ARG A2176
ILE A2175
ASP A2031
 None
 1.22A 6bxmA-4zwjA:
undetectable		 6bxmA-4zwjA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A2279
PRO A2222
VAL A2240
SER A2190
ILE A2330
 None
 1.25A 6fdyU-4zwjA:
undetectable		 6fdyU-4zwjA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus) 		5 / 9 PRO A2222
VAL A2240
SER A2190
LEU A2210
ILE A2330
 None
 1.32A 6fdyU-4zwjA:
undetectable		 6fdyU-4zwjA:
14.54