SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 9 GLY A 393
GLY A 358
ALA A 347
THR A 375
ILE A 354
 None
 0.93A 1gtfD-4zwlA:
undetectable
1gtfE-4zwlA:
undetectable		 1gtfD-4zwlA:
9.48
1gtfE-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A 393
GLY A 358
ALA A 347
THR A 375
ILE A 354
 None
 0.98A 1gtnL-4zwlA:
undetectable
1gtnV-4zwlA:
undetectable		 1gtnL-4zwlA:
9.48
1gtnV-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 LEU A 187
THR A 188
GLU A 194
ILE A  37
GLY A   0
 None
 0.93A 1qknA-4zwlA:
undetectable		 1qknA-4zwlA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A 358
ALA A 347
THR A 375
ILE A 354
GLY A 393
 None
 0.97A 1utdL-4zwlA:
undetectable
1utdM-4zwlA:
undetectable		 1utdL-4zwlA:
9.48
1utdM-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 11 GLY A 358
ALA A 347
THR A 375
ILE A 354
GLY A 393
 None
 0.93A 1utdP-4zwlA:
undetectable
1utdQ-4zwlA:
undetectable		 1utdP-4zwlA:
9.48
1utdQ-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 11 GLY A 358
ALA A 347
THR A 375
ILE A 354
GLY A 393
 None
 0.96A 1utdS-4zwlA:
undetectable
1utdT-4zwlA:
undetectable		 1utdS-4zwlA:
9.48
1utdT-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 11 GLY A 393
GLY A 358
ALA A 347
THR A 375
ILE A 354
 None
 0.96A 1utdL-4zwlA:
undetectable
1utdV-4zwlA:
undetectable		 1utdL-4zwlA:
9.48
1utdV-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 SER A 414
SER A 462
LEU A 418
GLY A 417
 None
None
NAD  A 501 (-4.4A)
None
 0.77A 2j2pA-4zwlA:
undetectable
2j2pC-4zwlA:
undetectable		 2j2pA-4zwlA:
17.80
2j2pC-4zwlA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 SER A 414
SER A 462
LEU A 418
GLY A 417
 None
None
NAD  A 501 (-4.4A)
None
 0.78A 2j2pD-4zwlA:
undetectable
2j2pF-4zwlA:
undetectable		 2j2pD-4zwlA:
17.80
2j2pF-4zwlA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 11 GLY A 281
ILE A 377
ALA A 347
VAL A 391
ILE A 340
 None
 1.06A 2nnhA-4zwlA:
undetectable		 2nnhA-4zwlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 10 SER A  41
ILE A 190
LEU A 208
ASN A 207
ILE A  13
 None
 1.21A 2nnhB-4zwlA:
undetectable		 2nnhB-4zwlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 10 ILE A 354
ALA A 347
VAL A 391
VAL A 395
ILE A 340
 None
 1.02A 2nnjA-4zwlA:
undetectable		 2nnjA-4zwlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A 329
GLY A  99
THR A  95
LEU A 102
GLY A 319
 None
 1.08A 3sglA-4zwlA:
2.1		 3sglA-4zwlA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 8 ASP A 218
GLY A 217
VAL A 229
HIS A 240
 NAD  A 501 (-4.5A)
NAD  A 501 (-3.4A)
None
NAD  A 501 (-4.1A)
 0.80A 4c5nC-4zwlA:
3.2		 4c5nC-4zwlA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 7 GLU A 104
GLU A 103
GLY A 319
LYS A 317
 None
 0.83A 4fgzA-4zwlA:
undetectable		 4fgzA-4zwlA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		3 / 3 GLY A 329
PRO A 330
GLN A 287
 None
 0.44A 4oltB-4zwlA:
undetectable		 4oltB-4zwlA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 ARG A  87
ALA A  91
ASP A 110
LEU A 102
 None
 0.82A 4ot2A-4zwlA:
undetectable		 4ot2A-4zwlA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A 292
ALA A 291
VAL A 288
TYR A 158
PHE A 448
 None
 1.14A 4pd5A-4zwlA:
undetectable		 4pd5A-4zwlA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A 292
ALA A 291
VAL A 288
TYR A 158
PHE A 448
 None
 1.11A 4pd9A-4zwlA:
undetectable		 4pd9A-4zwlA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		3 / 3 GLY A 329
PRO A 330
GLN A 287
 None
 0.35A 4qwpB-4zwlA:
0.8		 4qwpB-4zwlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		3 / 4 ARG A 466
GLY A 472
GLU A 471
 None
 0.60A 4z2dB-4zwlA:
undetectable
4z2dC-4zwlA:
2.1		 4z2dB-4zwlA:
21.38
4z2dC-4zwlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 5 GLY A 465
ARG A 466
GLY A 472
GLU A 471
 None
 1.02A 4z2eB-4zwlA:
undetectable
4z2eC-4zwlA:
2.1		 4z2eB-4zwlA:
21.38
4z2eC-4zwlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 ILE A 263
PHE A 265
ILE A 408
GLU A 404
 None
 1.30A 4zzcA-4zwlA:
undetectable
4zzcB-4zwlA:
undetectable		 4zzcA-4zwlA:
22.20
4zzcB-4zwlA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 ILE A 263
PHE A 265
ILE A 408
GLU A 404
 None
 1.35A 4zzcB-4zwlA:
undetectable
4zzcC-4zwlA:
undetectable		 4zzcB-4zwlA:
22.20
4zzcC-4zwlA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 11 ASP A 266
SER A 300
ASP A 267
GLU A 406
GLU A 404
 None
 1.24A 5iqbC-4zwlA:
0.0		 5iqbC-4zwlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		3 / 3 GLY A 148
ASP A 227
ASN A 248
 None
 0.40A 5jglA-4zwlA:
3.8		 5jglA-4zwlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 10 PRO A 181
GLY A 217
GLU A 215
GLY A 213
ALA A  48
 None
NAD  A 501 (-3.4A)
None
NAD  A 501 (-3.3A)
None
 1.11A 5o96E-4zwlA:
2.7
5o96F-4zwlA:
undetectable		 5o96E-4zwlA:
18.98
5o96F-4zwlA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 ALA A 291
GLY A 258
GLY A 257
GLU A 467
LEU A 468
 None
None
NAD  A 501 (-2.9A)
None
None
 1.21A 5ul4A-4zwlA:
3.9		 5ul4A-4zwlA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 8 ALA A  91
THR A  95
THR A  98
TRP A 156
 None
None
None
NAD  A 501 (-4.3A)
 0.72A 5x2tI-4zwlA:
undetectable
5x2tJ-4zwlA:
undetectable
5x2tK-4zwlA:
undetectable
5x2tL-4zwlA:
undetectable		 5x2tI-4zwlA:
14.09
5x2tJ-4zwlA:
15.34
5x2tK-4zwlA:
14.09
5x2tL-4zwlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4zwl BETAINE-ALDEHYDE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 8 THR A  95
THR A  98
ALA A 285
TRP A 156
 None
None
None
NAD  A 501 (-4.3A)
 0.89A 5x2tI-4zwlA:
undetectable
5x2tJ-4zwlA:
undetectable
5x2tK-4zwlA:
undetectable
5x2tL-4zwlA:
undetectable		 5x2tI-4zwlA:
14.09
5x2tJ-4zwlA:
15.34
5x2tK-4zwlA:
14.09
5x2tL-4zwlA:
15.34