SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  48
PHE A  49
SER A 123
MET A 124
HIS A 281
 None
 0.68A 1a8uA-4zwnA:
22.9		 1a8uA-4zwnA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  48
SER A 123
MET A 124
LEU A 151
HIS A 281
 None
 0.93A 1a8uA-4zwnA:
22.9		 1a8uA-4zwnA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  48
PHE A  49
SER A 123
MET A 124
HIS A 281
 None
 0.68A 1a8uB-4zwnA:
23.0		 1a8uB-4zwnA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  48
SER A 123
MET A 124
LEU A 151
HIS A 281
 None
 0.95A 1a8uB-4zwnA:
23.0		 1a8uB-4zwnA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 133
TYR A 145
LEU A 130
GLY A 127
GLY A 121
 None
 1.29A 1ncwH-4zwnA:
undetectable
1ncwL-4zwnA:
undetectable		 1ncwH-4zwnA:
18.34
1ncwL-4zwnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 123
SER A 282
ILE A 189
ASN A 254
 None
 1.00A 1pnlA-4zwnA:
undetectable
1pnlB-4zwnA:
undetectable		 1pnlA-4zwnA:
21.18
1pnlB-4zwnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 198
LEU A 199
TYR A  52
LEU A 208
TYR A   4
 None
 1.41A 1qabE-4zwnA:
undetectable		 1qabE-4zwnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 133
TYR A 145
LEU A 130
GLY A 127
GLY A 121
 None
 1.25A 1ru9H-4zwnA:
undetectable
1ru9L-4zwnA:
undetectable		 1ru9H-4zwnA:
18.34
1ru9L-4zwnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 133
TYR A 145
LEU A 130
GLY A 127
GLY A 121
 None
 1.25A 1ruaH-4zwnA:
undetectable
1ruaL-4zwnA:
undetectable		 1ruaH-4zwnA:
18.34
1ruaL-4zwnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 133
TYR A 145
LEU A 130
GLY A 127
GLY A 121
 None
 1.25A 1rulH-4zwnA:
undetectable
1rulL-4zwnA:
undetectable		 1rulH-4zwnA:
18.34
1rulL-4zwnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 133
TYR A 145
LEU A 130
GLY A 127
GLY A 121
 None
 1.25A 1rumH-4zwnA:
undetectable
1rumL-4zwnA:
undetectable		 1rumH-4zwnA:
18.34
1rumL-4zwnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 133
TYR A 145
LEU A 130
GLY A 127
GLY A 121
 None
 1.26A 1rupH-4zwnA:
undetectable
1rupL-4zwnA:
undetectable		 1rupH-4zwnA:
18.34
1rupL-4zwnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 258
ILE A 233
CYH A 134
PHE A  96
 None
 0.97A 3ko0B-4zwnA:
undetectable
3ko0J-4zwnA:
undetectable		 3ko0B-4zwnA:
14.98
3ko0J-4zwnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 200
LEU A 184
LEU A 186
ILE A 189
 None
 0.93A 3nbqB-4zwnA:
2.3		 3nbqB-4zwnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 200
LEU A 184
LEU A 186
ILE A 189
 None
 0.91A 3nbqC-4zwnA:
2.7		 3nbqC-4zwnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 262
ILE A 245
GLY A 127
CYH A 129
 None
 1.21A 3r0lD-4zwnA:
undetectable		 3r0lD-4zwnA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A   4
PHE A 198
PRO A   5
LEU A 199
 None
 1.42A 3tgvB-4zwnA:
undetectable		 3tgvB-4zwnA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A   4
PHE A 198
PRO A   5
LEU A 199
 None
 1.38A 3tgvC-4zwnA:
undetectable		 3tgvC-4zwnA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 218
PRO A 169
LEU A 170
ILE A 166
ALA A 223
 None
NO3  A 401 ( 4.9A)
None
NO3  A 401 ( 4.5A)
None
 1.13A 4a83A-4zwnA:
undetectable		 4a83A-4zwnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 253
THR A 252
THR A 288
VAL A 291
ILE A 283
 None
 1.22A 4i41A-4zwnA:
undetectable		 4i41A-4zwnA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 125
HIS A  47
ILE A 152
SER A 259
HIS A 247
 None
 1.23A 4pooB-4zwnA:
2.4		 4pooB-4zwnA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  42
LYS A 105
GLU A 109
 None
 0.70A 5d0yA-4zwnA:
undetectable		 5d0yA-4zwnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 213
ARG A 221
ARG A  76
 None
 1.02A 5vcgA-4zwnA:
undetectable		 5vcgA-4zwnA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  63
GLY A 121
ILE A 146
MET A 299
HIS A 281
 None
 1.24A 5y2tA-4zwnA:
undetectable		 5y2tA-4zwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B2W_A_AG2A401_1
(PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 185
ASP A 251
THR A 252
HIS A 157
ASN A 254
 None
 1.49A 6b2wA-4zwnA:
0.0		 6b2wA-4zwnA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 286
SER A 282
ASP A 251
ILE A  55
SER A 123
 None
 1.32A 6dlzB-4zwnA:
3.1
6dlzC-4zwnA:
undetectable		 6dlzB-4zwnA:
12.58
6dlzC-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  55
SER A 123
LEU A 286
SER A 282
ASP A 251
 None
 1.32A 6dlzA-4zwnA:
undetectable
6dlzD-4zwnA:
3.3		 6dlzA-4zwnA:
12.58
6dlzD-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 286
SER A 282
ASP A 251
ILE A  55
SER A 123
 None
 1.38A 6dm0A-4zwnA:
undetectable
6dm0D-4zwnA:
2.6		 6dm0A-4zwnA:
12.58
6dm0D-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A  55
SER A 123
LEU A 286
SER A 282
ASP A 251
 None
 1.38A 6dm0B-4zwnA:
0.5
6dm0C-4zwnA:
3.2		 6dm0B-4zwnA:
12.58
6dm0C-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 286
SER A 282
ASP A 251
ILE A  55
SER A 123
 None
 1.31A 6dm1B-4zwnA:
3.2
6dm1C-4zwnA:
undetectable		 6dm1B-4zwnA:
12.58
6dm1C-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  55
SER A 123
LEU A 286
SER A 282
ASP A 251
 None
 1.32A 6dm1A-4zwnA:
undetectable
6dm1D-4zwnA:
3.2		 6dm1A-4zwnA:
12.58
6dm1D-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 286
SER A 282
ASP A 251
ILE A  55
SER A 123
 None
 1.39A 6dm2A-4zwnA:
2.0
6dm2D-4zwnA:
3.2		 6dm2A-4zwnA:
12.58
6dm2D-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 286
SER A 282
ASP A 251
ILE A  55
SER A 123
 None
 1.33A 6dm2B-4zwnA:
3.2
6dm2C-4zwnA:
undetectable		 6dm2B-4zwnA:
12.58
6dm2C-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A  55
SER A 123
LEU A 286
SER A 282
ASP A 251
 None
 1.38A 6dm2B-4zwnA:
3.2
6dm2C-4zwnA:
2.0		 6dm2B-4zwnA:
12.58
6dm2C-4zwnA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zwn MONOGLYCERIDE LIPASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  55
SER A 123
LEU A 286
SER A 282
ASP A 251
 None
 1.33A 6dm2A-4zwnA:
undetectable
6dm2D-4zwnA:
3.3		 6dm2A-4zwnA:
12.58
6dm2D-4zwnA:
12.58