SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.26A 1fkfA-4zwoA:
undetectable		 1fkfA-4zwoA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.40A 1tcoC-4zwoA:
undetectable		 1tcoC-4zwoA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		4 / 6 ILE A  63
VAL A  52
VAL A 149
ILE A  22
 None
 0.75A 1uwhA-4zwoA:
undetectable		 1uwhA-4zwoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		4 / 6 TYR A  99
TYR A 103
GLN A  16
ILE A  12
 None
 1.28A 2pgzD-4zwoA:
undetectable
2pgzE-4zwoA:
undetectable		 2pgzD-4zwoA:
19.41
2pgzE-4zwoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 LYS A  57
LYS A  51
VAL A  52
 None
 1.10A 3brfA-4zwoA:
undetectable		 3brfA-4zwoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 11 ALA A 253
ALA A 254
LEU A 439
HIS A 336
PHE A 212
 None
None
None
MN  A 501 ( 3.5A)
GOA  A 506 (-3.5A)
 1.23A 3bszE-4zwoA:
undetectable		 3bszE-4zwoA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 PHE A  82
CYH A  68
PHE A  56
 None
 1.04A 3cr5X-4zwoA:
undetectable		 3cr5X-4zwoA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 GLU A 294
LEU A 297
ASP A 298
 None
 0.19A 3ko0A-4zwoA:
undetectable		 3ko0A-4zwoA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 GLU A 294
LEU A 297
ASP A 298
 None
 0.19A 3ko0T-4zwoA:
undetectable		 3ko0T-4zwoA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 9 THR A 203
ALA A 202
LEU A 200
ALA A 198
ASN A 214
 None
 1.37A 3kp6B-4zwoA:
undetectable		 3kp6B-4zwoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 12 LEU A 225
GLY A 333
GLY A 383
LEU A 282
ILE A 380
 None
 1.07A 3ku1G-4zwoA:
undetectable		 3ku1G-4zwoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 12 ILE A 320
SER A 389
ASP A 393
PRO A 331
LEU A 225
 None
 1.13A 3v8vA-4zwoA:
2.1		 3v8vA-4zwoA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 12 LEU A 242
GLU A 267
GLY A 415
ALA A 223
PHE A 386
 None
 1.22A 4hytC-4zwoA:
2.5		 4hytC-4zwoA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 LEU A 242
ARG A 258
MET A 433
 None
 0.83A 4m11C-4zwoA:
undetectable		 4m11C-4zwoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 12 ILE A 256
GLY A 246
ALA A 254
GLU A 381
THR A 434
 None
None
None
MN  A 501 ( 2.6A)
None
 1.31A 4xt8A-4zwoA:
undetectable		 4xt8A-4zwoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 12 GLY A 335
GLY A 293
LEU A 295
GLU A 381
HIS A 336
 None
None
None
MN  A 501 ( 2.6A)
MN  A 501 ( 3.5A)
 0.99A 5c0oF-4zwoA:
undetectable		 5c0oF-4zwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		5 / 12 LEU A 200
ALA A 202
ILE A 195
ALA A 185
ILE A 243
 None
 1.06A 5eypB-4zwoA:
undetectable		 5eypB-4zwoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 CYH A 368
LYS A 365
HIS A 296
 None
 1.20A 5js5A-4zwoA:
undetectable		 5js5A-4zwoA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		4 / 4 VAL A  52
LEU A 340
ASN A  65
ASP A  64
 None
 1.31A 5vcyA-4zwoA:
undetectable		 5vcyA-4zwoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 THR A 161
THR A  14
ARG A  18
 None
 0.93A 5wm2A-4zwoA:
undetectable		 5wm2A-4zwoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		4 / 6 ALA A 273
GLN A 277
GLN A 279
ASP A 421
 None
 1.47A 5y9aA-4zwoA:
undetectable		 5y9aA-4zwoA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		4 / 5 ALA A 202
TYR A 199
GLN A 177
ILE A 174
 None
 1.15A 6f6sA-4zwoA:
undetectable
6f6sB-4zwoA:
undetectable		 6f6sA-4zwoA:
11.35
6f6sB-4zwoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		3 / 3 PHE A 230
ARG A 232
GLN A 197
 None
 0.99A 6g1pB-4zwoA:
undetectable		 6g1pB-4zwoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E
(Alteromonas
sp.) 		4 / 7 TYR A 128
HIS A  34
LEU A 119
VAL A 115
 None
 1.17A 6g2pA-4zwoA:
undetectable		 6g2pA-4zwoA:
21.77