SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		5 / 9 LEU A  75
VAL A 155
GLY A 140
PRO A 153
ILE A 123
 None
GOL  A 401 (-4.0A)
None
None
None
 1.00A 1hpvA-4zwvA:
undetectable		 1hpvA-4zwvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 7 ILE A 123
PRO A 153
PHE A 151
ALA A 145
 None
 1.13A 1oniD-4zwvA:
undetectable
1oniE-4zwvA:
undetectable		 1oniD-4zwvA:
21.21
1oniE-4zwvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 6 PHE A 151
ALA A 145
ILE A 123
PRO A 153
 None
 1.12A 1oniH-4zwvA:
undetectable
1oniI-4zwvA:
undetectable		 1oniH-4zwvA:
21.21
1oniI-4zwvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 4 LEU A 199
PRO A 200
LEU A 204
ARG A 211
 None
 1.17A 2hrcA-4zwvA:
undetectable		 2hrcA-4zwvA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 8 HIS A 188
HIS A 260
ALA A 264
VAL A 349
 LLP  A 187 ( 4.8A)
None
None
None
 0.84A 2it4A-4zwvA:
undetectable		 2it4A-4zwvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		3 / 3 SER A 283
ASP A 101
ASP A 134
 None
 0.68A 2plwA-4zwvA:
undetectable		 2plwA-4zwvA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 4 LEU A 199
PRO A 200
LEU A 204
ARG A 211
 None
 1.16A 2pnjB-4zwvA:
2.5		 2pnjB-4zwvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		5 / 12 SER A 346
LEU A 105
VAL A 100
HIS A 161
LEU A   4
 None
None
None
LLP  A 187 ( 3.6A)
None
 1.32A 2prgB-4zwvA:
undetectable		 2prgB-4zwvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		3 / 3 LEU A 199
PRO A 200
LEU A 204
 None
 0.44A 2qd5B-4zwvA:
undetectable		 2qd5B-4zwvA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 4 LEU A 199
PRO A 200
LEU A 204
ARG A 211
 None
 1.05A 3hcoB-4zwvA:
2.0		 3hcoB-4zwvA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		3 / 3 SER A  53
GLY A  54
THR A  55
 LLP  A 187 ( 3.7A)
LLP  A 187 ( 3.4A)
LLP  A 187 ( 3.6A)
 0.16A 3k9wA-4zwvA:
undetectable		 3k9wA-4zwvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 8 ASP A 285
SER A 283
LEU A 138
ASP A 136
 None
 0.98A 3m0wE-4zwvA:
undetectable
3m0wF-4zwvA:
undetectable
3m0wG-4zwvA:
undetectable
3m0wH-4zwvA:
undetectable		 3m0wE-4zwvA:
14.13
3m0wF-4zwvA:
14.13
3m0wG-4zwvA:
14.13
3m0wH-4zwvA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		3 / 3 LEU A 199
PRO A 200
LEU A 204
 None
 0.49A 3w1wB-4zwvA:
2.4		 3w1wB-4zwvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 5 VAL A 170
GLY A 169
TYR A 167
ASP A 285
 None
 1.42A 3w9tA-4zwvA:
undetectable		 3w9tA-4zwvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 5 VAL A 170
GLY A 169
TYR A 167
ASP A 285
 None
 1.42A 3w9tB-4zwvA:
undetectable		 3w9tB-4zwvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 5 VAL A 170
GLY A 169
TYR A 167
ASP A 285
 None
 1.42A 3w9tC-4zwvA:
undetectable		 3w9tC-4zwvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 5 VAL A 170
GLY A 169
TYR A 167
ASP A 285
 None
 1.42A 3w9tD-4zwvA:
undetectable		 3w9tD-4zwvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 5 VAL A 170
GLY A 169
TYR A 167
ASP A 285
 None
 1.42A 3w9tE-4zwvA:
undetectable		 3w9tE-4zwvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 5 VAL A 170
GLY A 169
TYR A 167
ASP A 285
 None
 1.43A 3w9tF-4zwvA:
undetectable		 3w9tF-4zwvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 5 VAL A 170
GLY A 169
TYR A 167
ASP A 285
 None
 1.43A 3w9tG-4zwvA:
undetectable		 3w9tG-4zwvA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		5 / 11 LEU A  75
VAL A 155
GLY A 140
PRO A 153
ILE A 123
 None
GOL  A 401 (-4.0A)
None
None
None
 0.99A 4dqhA-4zwvA:
undetectable		 4dqhA-4zwvA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		5 / 11 VAL A 155
ALA A 122
THR A  77
LEU A 109
VAL A 125
 GOL  A 401 (-4.0A)
None
None
None
None
 1.44A 4kyaA-4zwvA:
undetectable		 4kyaA-4zwvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		6 / 12 ALA A  87
GLY A  54
GLY A  57
LEU A 196
LEU A 197
ALA A  83
 None
LLP  A 187 ( 3.4A)
None
None
None
LLP  A 187 ( 3.9A)
 1.43A 4lg1C-4zwvA:
undetectable		 4lg1C-4zwvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		5 / 11 LEU A 280
VAL A 345
SER A 346
LEU A 347
LEU A 105
 None
 1.03A 4or0B-4zwvA:
undetectable		 4or0B-4zwvA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 7 HIS A 205
ASN A  45
LEU A  43
VAL A  49
 None
 1.04A 5m8rA-4zwvA:
undetectable		 5m8rA-4zwvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 8 HIS A 205
ASN A  45
LEU A  43
VAL A  49
 None
 1.02A 5m8rB-4zwvA:
undetectable		 5m8rB-4zwvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 8 HIS A 205
ASN A  45
LEU A  43
VAL A  49
 None
 0.97A 5m8rD-4zwvA:
undetectable		 5m8rD-4zwvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		5 / 10 LEU A  58
HIS A 127
ALA A 162
SER A 289
LEU A  43
 None
 1.45A 5mm4B-4zwvA:
undetectable		 5mm4B-4zwvA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 6 PRO A  11
VAL A   9
ALA A 248
THR A 252
 None
 1.17A 5t7bA-4zwvA:
undetectable		 5t7bA-4zwvA:
16.71