SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		3 / 3 TRP E 489
ARG E 498
THR E 568
 None
 0.83A 1df7A-4zxbE:
undetectable		 1df7A-4zxbE:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 ILE E 439
ALA E 458
PHE E 427
PHE E 428
ILE E 370
 None
 1.15A 1dhfA-4zxbE:
undetectable		 1dhfA-4zxbE:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA E 327
PHE E 381
SER E 373
ILE E 370
LEU E 368
 None
 1.12A 1dlsA-4zxbE:
undetectable		 1dlsA-4zxbE:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR A 122
PRO A 152
THR A 121
PRO A 123
 None
 1.32A 1dsdC-4zxbA:
undetectable		 1dsdC-4zxbA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR A 122
PRO A 152
THR A 121
PRO A 123
 None
 1.32A 1dsdC-4zxbA:
undetectable		 1dsdC-4zxbA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU E 505
LYS E 531
MET E 553
ILE E 485
LEU E 487
 None
 1.20A 1lhuA-4zxbE:
undetectable		 1lhuA-4zxbE:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		4 / 6 GLU E 755
ILE E 781
TYR E 779
GLY E 778
 None
 1.16A 1maaB-4zxbE:
undetectable
1maaD-4zxbE:
undetectable		 1maaB-4zxbE:
19.80
1maaD-4zxbE:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 11 THR E 392
GLY E 338
GLU E 318
GLU E 394
ILE E 336
 None
 1.46A 1odiA-4zxbE:
undetectable		 1odiA-4zxbE:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4zxb FAB 83-7 HEAVY CHAIN
INSULIN RECEPTOR
(Homo
sapiens;
Mus
musculus) 		5 / 12 PHE A  27
SER A  25
LEU A   4
TYR A 100
THR E 223
 None
 1.17A 2oipB-4zxbA:
undetectable		 2oipB-4zxbA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
 None
 1.19A 2pnjB-4zxbE:
undetectable		 2pnjB-4zxbE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		6 / 12 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
LEU E 426
 None
 1.45A 2po5A-4zxbE:
undetectable		 2po5A-4zxbE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 11 LEU E 385
PHE E 382
LEU E 419
SER E 446
LEU E 426
 None
 1.26A 2po5B-4zxbE:
undetectable		 2po5B-4zxbE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL A 168
VAL A 186
SER A 184
ASN A 201
ASN A 160
 None
 1.49A 2y03B-4zxbA:
undetectable		 2y03B-4zxbA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
 None
 1.12A 3aqiB-4zxbE:
undetectable		 3aqiB-4zxbE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4zxb FAB 83-7 HEAVY CHAIN
INSULIN RECEPTOR
(Homo
sapiens;
Mus
musculus) 		5 / 12 PHE A  27
SER A  25
LEU A   4
TYR A 100
THR E 223
 None
 1.19A 3hj3A-4zxbA:
undetectable		 3hj3A-4zxbA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4zxb FAB 83-7 HEAVY CHAIN
INSULIN RECEPTOR
(Homo
sapiens;
Mus
musculus) 		5 / 12 PHE A  27
SER A  25
LEU A   4
TYR A 100
THR E 223
 None
 1.19A 3hj3C-4zxbA:
undetectable		 3hj3C-4zxbA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL A 168
VAL A 186
SER A 184
ASN A 201
ASN A 160
 None
 1.42A 3nyaA-4zxbA:
undetectable		 3nyaA-4zxbA:
17.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4zxb FAB 83-7 HEAVY CHAIN
INSULIN RECEPTOR
(Homo
sapiens;
Mus
musculus) 		3 / 3 LEU A   4
ARG E 236
ASN A  73
 None
 0.51A 3qxvD-4zxbA:
19.1		 3qxvD-4zxbA:
48.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
 None
 1.08A 3w1wA-4zxbE:
undetectable		 3w1wA-4zxbE:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL E 254
PHE E 231
HIS E 247
ARG E  83
GLU E  30
 None
 1.49A 4bvaA-4zxbE:
undetectable		 4bvaA-4zxbE:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL E 254
PHE E 231
HIS E 247
ARG E  83
GLU E  30
 None
 1.45A 4bvaB-4zxbE:
undetectable		 4bvaB-4zxbE:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA A  31
PHE A  27
SER A  25
LEU A   4
VAL A  34
 None
 1.18A 4eckB-4zxbA:
undetectable		 4eckB-4zxbA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		4 / 5 TYR A  93
LEU A  80
LEU A  85
ARG A  66
 None
 1.38A 4em2A-4zxbA:
undetectable		 4em2A-4zxbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 10 ILE E 336
GLY E 338
GLY E 317
SER E 326
THR E 320
 None
 0.94A 4fakA-4zxbE:
undetectable		 4fakA-4zxbE:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		4 / 7 ILE E  13
LEU E  17
PHE E  46
GLY E  68
 None
 1.05A 4hbfA-4zxbE:
undetectable		 4hbfA-4zxbE:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 10 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.02A 4odoA-4zxbE:
undetectable		 4odoA-4zxbE:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 10 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.06A 4odoB-4zxbE:
undetectable		 4odoB-4zxbE:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 10 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.09A 4odoC-4zxbE:
undetectable		 4odoC-4zxbE:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER A 208
ALA A 203
VAL A 202
 None
 0.60A 4x1iA-4zxbA:
undetectable		 4x1iA-4zxbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		3 / 3 THR E 461
ALA E 458
ASN E 462
 None
 0.50A 5ersA-4zxbE:
undetectable		 5ersA-4zxbE:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER A 208
ALA A 203
VAL A 202
 None
 0.57A 5eypA-4zxbA:
undetectable		 5eypA-4zxbA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER A 117
ALA A 119
PHE A 151
LEU A 175
 None
 0.41A 5mthA-4zxbA:
28.5		 5mthA-4zxbA:
71.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
 None
 1.28A 5tiwA-4zxbE:
undetectable		 5tiwA-4zxbE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 ILE E 336
GLY E 338
GLY E 317
SER E 326
THR E 320
 None
 1.00A 5twjA-4zxbE:
undetectable		 5twjA-4zxbE:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 12 ALA E 636
ARG E 774
GLY E 778
ILE E 781
GLU E 782
 None
 1.18A 5ul4A-4zxbE:
2.0		 5ul4A-4zxbE:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4zxb FAB 83-7 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER A 208
ALA A 203
VAL A 202
 None
 0.52A 5xiwC-4zxbA:
undetectable		 5xiwC-4zxbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		3 / 3 ARG E 870
PHE E 823
ARG E 873
 None
 0.98A 5y9yA-4zxbE:
undetectable		 5y9yA-4zxbE:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 4zxb INSULIN RECEPTOR
(Homo
sapiens) 		5 / 11 ILE E 478
LEU E 473
ARG E 488
PRO E 549
ILE E 534
 None
 1.28A 6fgdA-4zxbE:
undetectable		 6fgdA-4zxbE:
7.16