SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 ILE A 269
ASN A 169
SER A 172
THR A 278
 None
 1.25A 1h7xA-4zxkA:
undetectable		 1h7xA-4zxkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 ILE A 269
ASN A 169
SER A 172
THR A 278
 None
 1.25A 1h7xB-4zxkA:
undetectable		 1h7xB-4zxkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 ILE A 269
ASN A 169
SER A 172
THR A 278
 None
 1.24A 1h7xC-4zxkA:
undetectable		 1h7xC-4zxkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 ILE A 269
ASN A 169
SER A 172
THR A 278
 None
 1.25A 1h7xD-4zxkA:
undetectable		 1h7xD-4zxkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 6 GLN A 268
ALA A 275
ALA A 176
THR A 265
 None
 1.09A 2xfhA-4zxkA:
undetectable		 2xfhA-4zxkA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		3 / 3 TRP A 280
VAL A 154
ARG A 304
 None
 0.75A 3b0wA-4zxkA:
undetectable		 3b0wA-4zxkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 11 ASN A 293
LEU A 149
VAL A 173
ILE A 122
PHE A 171
 None
 1.24A 3jw5A-4zxkA:
undetectable		 3jw5A-4zxkA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 TYR A 205
LEU A 146
VAL A 267
PHE A 171
VAL A 291
 None
 1.47A 3u9fE-4zxkA:
undetectable		 3u9fE-4zxkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 12 TYR A 205
LEU A 146
VAL A 267
PHE A 171
VAL A 291
 None
 1.42A 3u9fH-4zxkA:
undetectable
3u9fI-4zxkA:
undetectable		 3u9fH-4zxkA:
21.05
3u9fI-4zxkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 9 TYR A 205
LEU A 146
VAL A 267
PHE A 171
VAL A 291
 None
 1.45A 3u9fP-4zxkA:
undetectable		 3u9fP-4zxkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		4 / 8 LEU A 170
THR A 193
TYR A 188
GLN A 203
 None
 1.06A 5hbsA-4zxkA:
undetectable		 5hbsA-4zxkA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 SER A 174
LEU A 289
LEU A 146
ILE A 269
SER A 140
 None
 1.33A 6dlzB-4zxkA:
undetectable
6dlzC-4zxkA:
undetectable		 6dlzB-4zxkA:
15.03
6dlzC-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 11 ILE A 269
SER A 140
SER A 174
LEU A 289
LEU A 146
 None
 1.32A 6dlzA-4zxkA:
undetectable
6dlzD-4zxkA:
undetectable		 6dlzA-4zxkA:
15.03
6dlzD-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 SER A 174
LEU A 289
LEU A 146
ILE A 269
SER A 140
 None
 1.33A 6dm1B-4zxkA:
undetectable
6dm1C-4zxkA:
undetectable		 6dm1B-4zxkA:
15.03
6dm1C-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 11 ILE A 269
SER A 140
SER A 174
LEU A 289
LEU A 146
 None
 1.32A 6dm1A-4zxkA:
undetectable
6dm1D-4zxkA:
undetectable		 6dm1A-4zxkA:
15.03
6dm1D-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 SER A 174
LEU A 289
LEU A 146
ILE A 269
SER A 140
 None
 1.37A 6dm2B-4zxkA:
undetectable
6dm2C-4zxkA:
undetectable		 6dm2B-4zxkA:
15.03
6dm2C-4zxkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zxk SIALIDASE A
(Streptococcus
pneumoniae) 		5 / 10 ILE A 269
SER A 140
SER A 174
LEU A 289
LEU A 146
 None
 1.37A 6dm2A-4zxkA:
undetectable
6dm2D-4zxkA:
undetectable		 6dm2A-4zxkA:
15.03
6dm2D-4zxkA:
15.03