SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zxs VIRION EGRESS
PROTEIN UL31
VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		5 / 12 ALA B  67
PHE B  65
ARG A  22
LEU B  68
ALA B  69
 None
 1.03A 1fm6U-4zxsB:
undetectable		 1fm6U-4zxsB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4zxs VIRION EGRESS
PROTEIN UL34
VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1;
Human
alphaherpesvirus
1) 		5 / 11 ILE A 119
ALA A 165
LEU B 116
ILE B 231
LEU B  98
 None
None
None
NA  B 402 (-3.8A)
None
 1.32A 2zzaB-4zxsA:
undetectable		 2zzaB-4zxsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4zxs VIRION EGRESS
PROTEIN UL31
VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		5 / 12 PHE B 243
ILE A 119
LEU B 116
VAL B  92
ILE B 231
 None
None
None
None
NA  B 402 (-3.8A)
 1.12A 3gwxB-4zxsB:
undetectable		 3gwxB-4zxsB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4zxs VIRION EGRESS
PROTEIN UL31
VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 119
ALA A 165
LEU B 116
ILE B 231
LEU B  98
 None
None
None
NA  B 402 (-3.8A)
None
 1.30A 3ia4B-4zxsA:
undetectable		 3ia4B-4zxsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4zxs VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		5 / 12 ASN A  82
PRO A  83
GLY A 127
VAL A 118
ILE A 111
 None
 1.47A 3jb2A-4zxsA:
undetectable		 3jb2A-4zxsA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4zxs VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		4 / 8 ILE A  87
PHE A 166
ALA A 165
VAL A  94
 None
 0.72A 3me6B-4zxsA:
undetectable		 3me6B-4zxsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		4 / 6 ARG B 257
LEU B 185
MET B 214
ASP B 207
 None
 1.40A 4cevA-4zxsB:
undetectable
4cevB-4zxsB:
undetectable		 4cevA-4zxsB:
22.39
4cevB-4zxsB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		4 / 6 MET B 214
ASP B 207
ARG B 257
LEU B 185
 None
 1.42A 4cevA-4zxsB:
undetectable
4cevC-4zxsB:
undetectable		 4cevA-4zxsB:
22.39
4cevC-4zxsB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		4 / 6 ARG B 257
LEU B 185
MET B 214
ASP B 207
 None
 1.44A 4cevD-4zxsB:
undetectable
4cevE-4zxsB:
undetectable		 4cevD-4zxsB:
22.39
4cevE-4zxsB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		4 / 6 PHE B 219
ALA B 224
ALA B 245
LEU B 226
 None
 0.97A 4dtzA-4zxsB:
undetectable		 4dtzA-4zxsB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		4 / 6 PHE B 219
ALA B 224
ALA B 245
LEU B 226
 None
 0.96A 4dtzB-4zxsB:
undetectable		 4dtzB-4zxsB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		3 / 3 TYR B 228
HIS B 227
ARG B 229
 None
 1.13A 4e7bC-4zxsB:
undetectable		 4e7bC-4zxsB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		4 / 7 VAL B 256
ILE B 191
ALA B 237
ARG B 155
 None
 0.75A 4uxqA-4zxsB:
undetectable		 4uxqA-4zxsB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		3 / 3 ARG B 257
THR B 209
ASP B 207
 None
 0.89A 5g5gA-4zxsB:
undetectable
5g5gB-4zxsB:
undetectable		 5g5gA-4zxsB:
24.56
5g5gB-4zxsB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		5 / 12 MET B 234
ILE B 231
VAL B 188
VAL B 256
THR B 251
 None
NA  B 402 (-3.8A)
None
None
None
 0.90A 5igjA-4zxsB:
0.8		 5igjA-4zxsB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zxs VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		4 / 4 LEU A 164
ARG A 167
ILE A 153
PHE A 166
 None
 1.23A 5kirB-4zxsA:
undetectable		 5kirB-4zxsA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4zxs VIRION EGRESS
PROTEIN UL34
VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1;
Human
alphaherpesvirus
1) 		5 / 12 MET A 169
MET A 151
ILE B 118
VAL B 102
TYR B 228
 None
 1.41A 5vlmE-4zxsA:
undetectable		 5vlmE-4zxsA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zxs VIRION EGRESS
PROTEIN UL31
(Human
alphaherpesvirus
1) 		5 / 12 LEU B 176
MET B 280
LEU B 289
LEU B 202
TYR B 293
 None
 1.45A 5y2oA-4zxsB:
undetectable		 5y2oA-4zxsB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4zxs VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		5 / 11 LEU A  85
GLY A 109
ILE A 111
ILE A 153
ILE A  87
 None
 1.04A 6gp2A-4zxsA:
undetectable		 6gp2A-4zxsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4zxs VIRION EGRESS
PROTEIN UL34
(Human
alphaherpesvirus
1) 		5 / 11 LEU A  85
GLY A 109
ILE A 111
ILE A 153
ILE A  87
 None
 1.03A 6gp2B-4zxsA:
undetectable		 6gp2B-4zxsA:
19.08