SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 6 LYS A 237
GLY A  37
ASN A 426
PRO A  41
 None
 1.29A 1dedA-4zxwA:
undetectable		 1dedA-4zxwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 LEU A  78
HIS A  85
ASP A  28
LEU A  24
 None
 0.98A 1e7cA-4zxwA:
undetectable		 1e7cA-4zxwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 7 PHE A 266
PHE A 368
ALA A 370
ILE A 413
 None
 1.00A 1fxhA-4zxwA:
undetectable
1fxhB-4zxwA:
undetectable		 1fxhA-4zxwA:
18.80
1fxhB-4zxwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 LEU A 133
LEU A  78
LEU A  24
SER A  18
 None
 1.13A 1hk2A-4zxwA:
undetectable		 1hk2A-4zxwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 LEU A  74
ALA A 159
ALA A 161
VAL A  68
HIS A 154
 None
None
None
None
4T7  A 501 (-4.1A)
 1.22A 1kt4A-4zxwA:
undetectable		 1kt4A-4zxwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.88A 1rxcB-4zxwA:
undetectable		 1rxcB-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 7 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.91A 1rxcD-4zxwA:
undetectable		 1rxcD-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.89A 1rxcE-4zxwA:
undetectable		 1rxcE-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 7 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.85A 1rxcF-4zxwA:
undetectable		 1rxcF-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.91A 1rxcI-4zxwA:
undetectable		 1rxcI-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.89A 1rxcK-4zxwA:
undetectable		 1rxcK-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 9 LEU A  64
ALA A 152
LEU A 126
GLU A 122
LEU A 118
 None
None
None
SUC  A 502 ( 4.8A)
None
 1.33A 2azqA-4zxwA:
undetectable		 2azqA-4zxwA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 GLY A 248
ILE A 411
LEU A 446
LEU A 443
TYR A 442
 None
 1.13A 3cs8A-4zxwA:
undetectable		 3cs8A-4zxwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 ALA A 159
VAL A  46
GLY A  47
HIS A 412
VAL A 371
 None
SUC  A 502 (-3.9A)
SUC  A 502 ( 4.8A)
None
None
 0.76A 3f8wA-4zxwA:
undetectable		 3f8wA-4zxwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 9 LEU A 277
THR A 281
GLU A 283
ILE A 365
LEU A 225
 None
 1.33A 3hy7A-4zxwA:
undetectable		 3hy7A-4zxwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		3 / 3 ARG A  80
ASP A 402
GLN A 364
 None
 0.91A 3lcvB-4zxwA:
undetectable		 3lcvB-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 6 VAL A 371
VAL A 367
ILE A 308
ARG A 243
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-4.7A)
 1.09A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 6 VAL A 371
VAL A 367
ILE A 308
ARG A 393
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-3.7A)
 1.05A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 5 ILE A  45
ALA A 157
MET A 162
ARG A 295
 SUC  A 502 (-4.3A)
None
None
None
 1.29A 4ac9B-4zxwA:
undetectable
4ac9C-4zxwA:
undetectable		 4ac9B-4zxwA:
21.91
4ac9C-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 5 ILE A  45
ALA A 157
MET A 162
ARG A 295
 SUC  A 502 (-4.3A)
None
None
None
 1.30A 4acaB-4zxwA:
undetectable
4acaC-4zxwA:
undetectable		 4acaB-4zxwA:
21.91
4acaC-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.78A 4e1vA-4zxwA:
undetectable		 4e1vA-4zxwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.85A 4e1vD-4zxwA:
undetectable		 4e1vD-4zxwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.84A 4e1vG-4zxwA:
undetectable		 4e1vG-4zxwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		3 / 3 HIS A 154
TRP A 241
SER A 306
 4T7  A 501 (-4.1A)
SUC  A 502 (-4.5A)
None
 0.99A 4lrhD-4zxwA:
undetectable		 4lrhD-4zxwA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 ALA A 373
ALA A 166
ALA A  48
GLY A  47
LEU A 150
 None
None
None
SUC  A 502 ( 4.8A)
None
 1.01A 4oaeA-4zxwA:
undetectable		 4oaeA-4zxwA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 GLU A  98
LEU A 169
LEU A  64
ARG A 135
LEU A 134
 None
 1.20A 5v0vA-4zxwA:
undetectable		 5v0vA-4zxwA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 PHE A 212
PHE A 338
SER A 264
PHE A 270
ALA A 271
 None
 1.11A 5vc0A-4zxwA:
undetectable		 5vc0A-4zxwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 4 SER A  29
THR A 155
ASP A 158
ASP A 402
 None
 1.48A 5vimA-4zxwA:
undetectable		 5vimA-4zxwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 GLY A 103
ARG A  50
ASP A 145
ASP A 106
 SO4  A 505 ( 4.6A)
None
None
None
 0.92A 5vlmB-4zxwA:
undetectable		 5vlmB-4zxwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		3 / 3 ARG A 295
PHE A  19
PHE A 300
 None
 0.92A 6nknC-4zxwA:
undetectable
6nknJ-4zxwA:
undetectable		 6nknC-4zxwA:
19.76
6nknJ-4zxwA:
8.16