SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 ALA A 382
GLY A  99
GLY A 219
LEU A  53
LEU A 104
 None
 1.01A 1ej0A-4zyjA:
undetectable		 1ej0A-4zyjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 11 LEU A 172
MET A 220
MET A 264
ILE A 267
HIS A 105
 None
 1.27A 1g50A-4zyjA:
undetectable		 1g50A-4zyjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 9 LEU A  57
LEU A  37
ILE A  93
VAL A  66
MET A  61
 None
 1.39A 1gx8A-4zyjA:
undetectable		 1gx8A-4zyjA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 11 ASP A  48
SER A 370
ASN A 369
ARG A 378
GLY A 366
 None
 1.30A 1jr1A-4zyjA:
undetectable		 1jr1A-4zyjA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 VAL A  12
LEU A 265
LEU A 307
ALA A 272
ALA A  94
 None
 1.15A 1sa1A-4zyjA:
undetectable
1sa1B-4zyjA:
undetectable		 1sa1A-4zyjA:
24.22
1sa1B-4zyjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 6 LEU A  78
ALA A  25
LEU A  29
THR A  23
 None
 1.30A 1tyrA-4zyjA:
undetectable		 1tyrA-4zyjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 10 ALA A  94
MET A 264
LEU A  90
MET A 175
SER A 225
 None
 1.39A 1wrlC-4zyjA:
undetectable
1wrlD-4zyjA:
undetectable		 1wrlC-4zyjA:
11.30
1wrlD-4zyjA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 5 ILE A 267
ILE A 278
MET A 220
LEU A 304
 None
 0.94A 1zgyA-4zyjA:
undetectable		 1zgyA-4zyjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 9 GLU A 273
LEU A  33
LEU A  37
ALA A  98
ALA A  91
 None
 1.45A 2bxcB-4zyjA:
2.5		 2bxcB-4zyjA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 5 ASN A 348
ALA A 310
LEU A  18
GLY A 266
 None
 0.90A 3dl9A-4zyjA:
undetectable		 3dl9A-4zyjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 8 VAL A  71
GLY A 111
ARG A 110
GLY A  68
 None
 0.78A 3n9jB-4zyjA:
undetectable		 3n9jB-4zyjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 ALA A  25
GLY A  68
ARG A 110
GLU A  73
VAL A  71
 None
 1.09A 3o7wA-4zyjA:
undetectable		 3o7wA-4zyjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 5 TYR A 268
VAL A 347
SER A 351
GLY A 384
 None
 1.35A 3v4tA-4zyjA:
undetectable
3v4tD-4zyjA:
undetectable		 3v4tA-4zyjA:
24.18
3v4tD-4zyjA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 5 TYR A 268
VAL A 380
SER A 351
GLY A 270
 None
 1.48A 3v4tA-4zyjA:
undetectable
3v4tD-4zyjA:
undetectable		 3v4tA-4zyjA:
24.18
3v4tD-4zyjA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 ILE A  93
ILE A 178
LEU A  40
LEU A  67
LEU A  32
 None
 0.96A 3vw1B-4zyjA:
3.1		 3vw1B-4zyjA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 11 GLY A  99
ALA A 263
PRO A  54
MET A 175
PHE A  58
 None
 1.29A 4j4vA-4zyjA:
1.3		 4j4vA-4zyjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 10 GLY A  99
ALA A 263
PRO A  54
MET A 175
PHE A  58
 None
 1.28A 4j4vB-4zyjA:
undetectable		 4j4vB-4zyjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 8 GLY A  99
PRO A  54
MET A 175
PHE A  58
 None
 1.00A 4j4vC-4zyjA:
undetectable		 4j4vC-4zyjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 10 GLY A  99
ALA A 263
PRO A  54
MET A 175
PHE A  58
 None
 1.31A 4j4vA-4zyjA:
1.3
4j4vE-4zyjA:
undetectable		 4j4vA-4zyjA:
20.28
4j4vE-4zyjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 5 LEU A  37
PRO A  38
LEU A  40
ILE A  93
 None
 1.04A 4klrA-4zyjA:
undetectable		 4klrA-4zyjA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4zyj DNMZ
(Streptomyces
peucetius) 		3 / 3 ASN A 369
ASP A  48
ASP A 216
 None
 0.65A 4obwD-4zyjA:
undetectable		 4obwD-4zyjA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 VAL A 259
HIS A 120
ALA A 255
MET A 336
ASP A 323
 TYD  A 501 (-4.3A)
None
TYD  A 501 ( 3.8A)
None
None
 1.27A 4qckA-4zyjA:
undetectable		 4qckA-4zyjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		3 / 3 ASP A 236
ARG A 165
PRO A 234
 None
 1.00A 4wanC-4zyjA:
undetectable		 4wanC-4zyjA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4zyj DNMZ
(Streptomyces
peucetius) 		3 / 5 GLY A  68
GLY A  76
GLU A  73
 None
 0.50A 4z2eA-4zyjA:
undetectable
4z2eD-4zyjA:
undetectable		 4z2eA-4zyjA:
23.64
4z2eD-4zyjA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 7 LEU A  88
LYS A  22
PRO A  21
LEU A  18
 None
 0.97A 4z4fA-4zyjA:
undetectable		 4z4fA-4zyjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 PRO A  72
MET A 136
LEU A 133
VAL A  80
LEU A 104
 None
 1.26A 5bykA-4zyjA:
undetectable		 5bykA-4zyjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 LEU A 166
PHE A 230
VAL A 202
PRO A 200
GLY A 244
 None
 1.35A 5f9zB-4zyjA:
undetectable		 5f9zB-4zyjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 PHE A  58
ALA A 103
PRO A  54
SER A 222
ILE A  93
 None
 1.38A 5ljbA-4zyjA:
undetectable		 5ljbA-4zyjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 LEU A 307
VAL A 355
GLY A 270
ALA A  91
LEU A 315
 None
 1.39A 5x23A-4zyjA:
undetectable		 5x23A-4zyjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4zyj DNMZ
(Streptomyces
peucetius) 		5 / 12 VAL A 184
SER A 185
THR A 186
VAL A 229
GLY A 168
 None
 1.05A 6a94B-4zyjA:
3.3		 6a94B-4zyjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4zyj DNMZ
(Streptomyces
peucetius) 		4 / 8 ALA A  89
GLY A  26
LEU A  29
ALA A  69
 None
 0.78A 6mdqA-4zyjA:
2.6		 6mdqA-4zyjA:
10.53