SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		5 / 9 VAL A  67
VAL A  81
LEU A  85
ALA A  13
LEU A  69
 None
 1.14A 1eqgA-4zylA:
undetectable		 1eqgA-4zylA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		5 / 11 VAL A  67
VAL A  81
LEU A  85
ALA A  13
LEU A  69
 None
 1.14A 1eqgB-4zylA:
undetectable		 1eqgB-4zylA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		5 / 10 ILE A 133
PHE A  27
ILE A  32
ILE A  66
LEU A  36
 None
 1.31A 3o1xA-4zylA:
undetectable		 3o1xA-4zylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		5 / 9 TYR A 129
LEU A 120
LEU A  99
VAL A  10
VAL A  12
 None
 1.44A 4c9kB-4zylA:
undetectable		 4c9kB-4zylA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 ILE A 114
VAL A  82
LEU A  85
VAL A  67
LEU A  71
 None
 1.44A 4m11D-4zylA:
undetectable		 4m11D-4zylA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 ASP A  19
ASP A  70
ALA A  98
TYR A 119
 None
 0.95A 4mdaA-4zylA:
undetectable		 4mdaA-4zylA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 ASP A  19
ASP A  70
ALA A  98
TYR A 119
 None
 0.95A 4mdbA-4zylA:
undetectable		 4mdbA-4zylA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		3 / 3 PRO A   8
LEU A 136
SER A  33
 None
 0.78A 5fsaB-4zylA:
undetectable		 5fsaB-4zylA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		4 / 5 VAL A  81
THR A  45
ASP A  41
LEU A  76
 None
 1.19A 5m0iB-4zylA:
undetectable		 5m0iB-4zylA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		4 / 8 ASP A  77
HIS A 107
ARG A  79
GLU A 110
 None
 1.22A 6mn4A-4zylA:
undetectable		 6mn4A-4zylA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4zyl RPHYB PROTEIN
(Rhodopseudomonas
palustris) 		4 / 8 ASP A  77
HIS A 107
ARG A  79
GLU A 110
 None
 1.16A 6mn4B-4zylA:
undetectable		 6mn4B-4zylA:
20.22