SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 12 HIS A 161
HIS A 120
ALA A 310
HIS A 301
HIS A 302
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
None
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
 1.16A 1a4lA-4zyoA:
undetectable		 1a4lA-4zyoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 12 HIS A 161
HIS A 120
ALA A 310
HIS A 301
HIS A 302
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
None
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
 1.12A 1a4lC-4zyoA:
undetectable		 1a4lC-4zyoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 TRP A 123
ALA A 207
VAL A 211
 None
 0.95A 1av2C-4zyoA:
undetectable
1av2D-4zyoA:
undetectable		 1av2C-4zyoA:
4.47
1av2D-4zyoA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 HIS A 157
HIS A 125
HIS A 120
HIS A 302
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.3A)
ZN  A 402 (-3.5A)
 1.01A 1azmA-4zyoA:
undetectable		 1azmA-4zyoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 HIS A 157
HIS A 161
HIS A 125
HIS A 298
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.03A 1azmA-4zyoA:
undetectable		 1azmA-4zyoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 VAL A 264
TRP A 262
TRP A 184
 ST9  A 403 (-4.8A)
ST9  A 403 (-4.2A)
None
 1.10A 1c4dA-4zyoA:
undetectable
1c4dB-4zyoA:
undetectable		 1c4dA-4zyoA:
4.47
1c4dB-4zyoA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 10 ASN A 265
ASP A 169
HIS A 120
HIS A 157
HIS A 301
 ST9  A 403 (-2.9A)
None
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
 1.40A 1ivvB-4zyoA:
undetectable		 1ivvB-4zyoA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 11 THR A 116
ASN A 318
GLU A 295
ILE A 324
ASP A 325
 ST9  A 403 (-4.2A)
None
None
None
None
 1.45A 1t6zA-4zyoA:
undetectable		 1t6zA-4zyoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 TRP A 123
ALA A 207
VAL A 211
 None
 1.00A 1w5uA-4zyoA:
undetectable
1w5uB-4zyoA:
undetectable		 1w5uA-4zyoA:
4.47
1w5uB-4zyoA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 6 SER A 309
ALA A 310
SER A 311
THR A 321
 None
 0.70A 1yvpB-4zyoA:
undetectable		 1yvpB-4zyoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 12 LEU A 290
GLY A 291
HIS A 120
THR A 116
ILE A 115
 None
None
ZN  A 401 ( 3.3A)
ST9  A 403 (-4.2A)
ST9  A 403 (-4.1A)
 1.39A 1z95A-4zyoA:
undetectable		 1z95A-4zyoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 11 LEU A 113
ALA A 333
LEU A 332
MET A 327
LEU A 138
 None
 1.20A 2c12F-4zyoA:
undetectable		 2c12F-4zyoA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 7 SER A 309
ALA A 310
SER A 311
THR A 321
 None
 0.79A 2i91A-4zyoA:
undetectable		 2i91A-4zyoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 7 SER A 309
ALA A 310
SER A 311
THR A 321
 None
 0.80A 2i91B-4zyoA:
undetectable		 2i91B-4zyoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 ALA A 207
VAL A 211
TRP A 123
 None
 0.92A 2izqA-4zyoA:
undetectable
2izqB-4zyoA:
undetectable		 2izqA-4zyoA:
4.47
2izqB-4zyoA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 7 TYR A 306
HIS A 125
TYR A 300
HIS A 302
 None
ZN  A 401 (-3.2A)
None
ZN  A 402 (-3.5A)
 1.28A 2ombC-4zyoA:
undetectable
2ombD-4zyoA:
undetectable		 2ombC-4zyoA:
19.38
2ombD-4zyoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 6 TYR A 300
HIS A 161
ASP A 307
HIS A 120
 None
ZN  A 401 (-3.3A)
None
ZN  A 401 ( 3.3A)
 1.45A 2r6vA-4zyoA:
undetectable		 2r6vA-4zyoA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 120
HIS A 125
HIS A 157
HIS A 301
 ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
 0.93A 2wkoA-4zyoA:
undetectable		 2wkoA-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 161
HIS A 160
HIS A 157
HIS A 302
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.5A)
 0.83A 2wkoA-4zyoA:
undetectable		 2wkoA-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 302
HIS A 301
HIS A 298
HIS A 161
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.3A)
 0.91A 2wkoA-4zyoA:
undetectable		 2wkoA-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 5 HIS A 120
HIS A 125
HIS A 157
HIS A 301
 ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
 0.99A 2wkoF-4zyoA:
undetectable		 2wkoF-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 5 HIS A 161
HIS A 160
HIS A 157
HIS A 302
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.5A)
 0.89A 2wkoF-4zyoA:
undetectable		 2wkoF-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 5 HIS A 302
HIS A 301
HIS A 298
HIS A 161
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.3A)
 0.97A 2wkoF-4zyoA:
undetectable		 2wkoF-4zyoA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 6 TYR A 254
ALA A 255
LEU A 258
ASN A  75
 None
None
None
ST9  A 403 (-3.4A)
 0.88A 3b6hB-4zyoA:
undetectable		 3b6hB-4zyoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 VAL A 193
LYS A 196
HIS A 302
 ST9  A 403 (-4.8A)
LMT  A 404 (-3.5A)
ZN  A 402 (-3.5A)
 0.86A 3elzA-4zyoA:
undetectable		 3elzA-4zyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 HIS A 160
HIS A 302
HIS A 269
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
 0.56A 3qpkA-4zyoA:
undetectable		 3qpkA-4zyoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 302
HIS A 161
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.27A 3qpkA-4zyoA:
undetectable		 3qpkA-4zyoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 HIS A 160
HIS A 302
HIS A 269
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
 0.58A 3qpkB-4zyoA:
undetectable		 3qpkB-4zyoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 302
HIS A 161
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.25A 3qpkB-4zyoA:
undetectable		 3qpkB-4zyoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 10 PHE A 323
VAL A 293
PHE A 319
PHE A 137
GLY A 114
 None
ST9  A 403 (-4.8A)
None
None
None
 1.20A 3t3rD-4zyoA:
undetectable		 3t3rD-4zyoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 ASN A 318
ALA A 310
ARG A 121
 None
 0.88A 3tj7C-4zyoA:
undetectable
3tj7D-4zyoA:
undetectable		 3tj7C-4zyoA:
19.30
3tj7D-4zyoA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 12 ILE A 115
GLN A 147
HIS A 160
PRO A 282
VAL A 264
 ST9  A 403 (-4.1A)
ST9  A 403 (-3.5A)
ZN  A 402 (-3.2A)
None
ST9  A 403 (-4.8A)
 1.03A 3w1wB-4zyoA:
undetectable		 3w1wB-4zyoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 HIS A 157
HIS A 125
HIS A 120
HIS A 302
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.3A)
ZN  A 402 (-3.5A)
 1.01A 3w6hA-4zyoA:
undetectable		 3w6hA-4zyoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 HIS A 157
HIS A 161
HIS A 125
HIS A 298
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.03A 3w6hA-4zyoA:
undetectable		 3w6hA-4zyoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1226_0
(THAUMATIN-LIKE
PROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 5 GLU A 152
TYR A 218
ASP A 149
PHE A 146
 None
None
None
ST9  A 403 (-4.4A)
 1.19A 3zs3A-4zyoA:
undetectable		 3zs3A-4zyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 161
HIS A 157
HIS A 302
HIS A 301
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
 1.11A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 161
HIS A 120
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
 1.12A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 302
HIS A 269
HIS A 161
HIS A 160
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
 1.14A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 302
HIS A 298
HIS A 161
HIS A 160
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
 1.02A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 5 HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.25A 4ef3A-4zyoA:
undetectable		 4ef3A-4zyoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 7 PHE A 323
VAL A 293
PHE A 137
GLY A 114
 None
ST9  A 403 (-4.8A)
None
None
 0.78A 4ejjB-4zyoA:
undetectable		 4ejjB-4zyoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 5 HIS A 269
HIS A 157
HIS A 161
HIS A 302
 ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.5A)
 0.94A 4h9mA-4zyoA:
undetectable		 4h9mA-4zyoA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 TRP A 103
GLN A 243
THR A 231
 None
 1.00A 4m2xA-4zyoA:
undetectable		 4m2xA-4zyoA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 7 HIS A 302
HIS A 120
HIS A 157
ARG A 158
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
None
 0.99A 4p6sB-4zyoA:
undetectable		 4p6sB-4zyoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 THR A 241
ASN A 244
SER A 245
 None
 0.70A 4tvtA-4zyoA:
undetectable		 4tvtA-4zyoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 12 HIS A 120
SER A 127
GLU A 295
GLY A 294
GLY A 114
 ZN  A 401 ( 3.3A)
None
None
None
None
 1.24A 4uilH-4zyoA:
undetectable
4uilL-4zyoA:
undetectable		 4uilH-4zyoA:
20.81
4uilL-4zyoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 12 HIS A 120
SER A 127
GLU A 295
GLY A 294
GLY A 114
 ZN  A 401 ( 3.3A)
None
None
None
None
 1.24A 4uinH-4zyoA:
undetectable
4uinL-4zyoA:
undetectable		 4uinH-4zyoA:
20.48
4uinL-4zyoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 ASP A 325
ILE A 344
ASP A 307
TYR A 306
 None
 0.94A 4xjeA-4zyoA:
1.0		 4xjeA-4zyoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 ASP A 325
ILE A 344
ASP A 307
TYR A 306
 None
 0.97A 5cfsA-4zyoA:
1.0		 5cfsA-4zyoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 THR A 321
SER A 309
TYR A 308
 None
 0.79A 5jsdA-4zyoA:
undetectable		 5jsdA-4zyoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 THR A 321
SER A 309
TYR A 308
 None
 0.79A 5jsdB-4zyoA:
undetectable		 5jsdB-4zyoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 THR A 321
SER A 309
TYR A 308
 None
 0.79A 5jsdC-4zyoA:
undetectable		 5jsdC-4zyoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 THR A 321
SER A 309
TYR A 308
 None
 0.81A 5jseA-4zyoA:
undetectable		 5jseA-4zyoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 THR A 321
SER A 309
TYR A 308
 None
 0.82A 5jseB-4zyoA:
undetectable		 5jseB-4zyoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 THR A 321
SER A 309
TYR A 308
 None
 0.81A 5jseC-4zyoA:
undetectable		 5jseC-4zyoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 5 HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.17A 5mejA-4zyoA:
undetectable		 5mejA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 5 HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.17A 5mewA-4zyoA:
undetectable		 5mewA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 5 HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.17A 5mhuA-4zyoA:
undetectable		 5mhuA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		5 / 5 HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.17A 5mhvA-4zyoA:
undetectable		 5mhvA-4zyoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 0.98A 5mhwA-4zyoA:
undetectable		 5mhwA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 0.99A 5mhxA-4zyoA:
undetectable		 5mhxA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 302
HIS A 161
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.31A 5mhxA-4zyoA:
undetectable		 5mhxA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 0.99A 5mhyA-4zyoA:
undetectable		 5mhyA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 302
HIS A 161
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.31A 5mhyA-4zyoA:
undetectable		 5mhyA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.00A 5mhzA-4zyoA:
undetectable		 5mhzA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 302
HIS A 161
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.32A 5mhzA-4zyoA:
undetectable		 5mhzA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 0.99A 5mi1A-4zyoA:
undetectable		 5mi1A-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 302
HIS A 161
HIS A 125
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.32A 5mi1A-4zyoA:
undetectable		 5mi1A-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 0.99A 5mi2A-4zyoA:
undetectable		 5mi2A-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.00A 5miaA-4zyoA:
undetectable		 5miaA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.00A 5mibA-4zyoA:
undetectable		 5mibA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.00A 5micA-4zyoA:
undetectable		 5micA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.00A 5midA-4zyoA:
undetectable		 5midA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.00A 5mieA-4zyoA:
undetectable		 5mieA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 HIS A 160
HIS A 302
HIS A 269
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
 0.53A 5migA-4zyoA:
undetectable		 5migA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 HIS A 171
ASP A 169
HIS A 160
 ST9  A 403 (-4.3A)
None
ZN  A 402 (-3.2A)
 0.92A 5n1tW-4zyoA:
undetectable		 5n1tW-4zyoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 HIS A 298
HIS A 302
TRP A 153
HIS A 171
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ST9  A 403 (-4.0A)
ST9  A 403 (-4.3A)
 0.93A 5nekD-4zyoA:
undetectable		 5nekD-4zyoA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 6 HIS A 157
HIS A 269
HIS A 302
HIS A 171
 ZN  A 401 ( 3.2A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ST9  A 403 (-4.3A)
 1.09A 5nelB-4zyoA:
undetectable
5nelC-4zyoA:
undetectable		 5nelB-4zyoA:
22.43
5nelC-4zyoA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 GLY A  89
LEU A  92
ASN A 244
SER A 245
 None
 0.87A 5xu8A-4zyoA:
undetectable		 5xu8A-4zyoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 8 LEU A  92
ASN A 244
SER A 245
ALA A 249
 None
 0.98A 5xu8A-4zyoA:
undetectable		 5xu8A-4zyoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		3 / 3 HIS A 120
HIS A 125
HIS A 157
 ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
 0.50A 5zrdA-4zyoA:
undetectable		 5zrdA-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 5 HIS A 125
HIS A 157
HIS A 120
HIS A 301
 ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.4A)
 1.10A 5zrdB-4zyoA:
undetectable		 5zrdB-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 5 HIS A 157
HIS A 120
HIS A 125
HIS A 161
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
 1.09A 5zrdB-4zyoA:
undetectable		 5zrdB-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 125
HIS A 120
HIS A 301
HIS A 161
 ZN  A 401 (-3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 1.14A 5zrdC-4zyoA:
undetectable		 5zrdC-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 125
HIS A 157
HIS A 120
HIS A 301
 ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.4A)
 1.12A 5zrdC-4zyoA:
undetectable		 5zrdC-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 157
HIS A 120
HIS A 125
HIS A 161
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
 1.07A 5zrdC-4zyoA:
undetectable		 5zrdC-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 160
HIS A 269
HIS A 298
HIS A 302
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.04A 5zrdC-4zyoA:
undetectable		 5zrdC-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 161
HIS A 157
HIS A 125
HIS A 301
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.09A 5zrdC-4zyoA:
undetectable		 5zrdC-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 125
HIS A 120
HIS A 301
HIS A 161
 ZN  A 401 (-3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 1.11A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 125
HIS A 157
HIS A 120
HIS A 301
 ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.4A)
 1.12A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 157
HIS A 120
HIS A 125
HIS A 161
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
 1.07A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 160
HIS A 269
HIS A 298
HIS A 302
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.02A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4zyo ACYL-COA DESATURASE
(Homo
sapiens) 		4 / 4 HIS A 161
HIS A 157
HIS A 125
HIS A 301
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.07A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57