SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)		 4zys EXOTOXIN 6
(Staphylococcus
aureus) 		5 / 12 ARG A 165
LEU A 103
ASP A  99
SER A 115
ILE A  80
 None
 1.46A 1i6vC-4zysA:
undetectable		 1i6vC-4zysA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4zys EXOTOXIN 6
(Staphylococcus
aureus) 		5 / 12 LEU A 159
ILE A 116
ASP A 163
ILE A 186
ASP A 211
 None
 1.23A 3axtA-4zysA:
undetectable		 3axtA-4zysA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4zys EXOTOXIN 6
(Staphylococcus
aureus) 		4 / 6 ASN A  97
ASP A 156
GLY A 118
THR A  57
 None
 1.06A 4l1aB-4zysA:
undetectable		 4l1aB-4zysA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4zys EXOTOXIN 6
(Staphylococcus
aureus) 		3 / 3 ASP A  94
LYS A  60
LEU A  82
 None
 1.07A 4ptjA-4zysA:
undetectable		 4ptjA-4zysA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4zys EXOTOXIN 6
(Staphylococcus
aureus) 		4 / 5 HIS A 196
ILE A 221
ILE A 218
TYR A 150
 CL  A 301 (-4.3A)
None
None
None
 1.14A 5dnvA-4zysA:
undetectable		 5dnvA-4zysA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4zys EXOTOXIN 6
(Staphylococcus
aureus) 		5 / 12 ILE A  98
PHE A  90
ASN A  97
ILE A  80
LEU A  82
 None
 1.15A 6dwnC-4zysA:
undetectable		 6dwnC-4zysA:
19.68