SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 6 ILE A  86
PRO A 151
GLU A 100
PHE A 148
 None
None
None
NAD  A 501 (-4.1A)
 1.31A 1oniA-4zz7A:
undetectable
1oniC-4zz7A:
undetectable		 1oniA-4zz7A:
16.34
1oniC-4zz7A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 5 PRO A 443
GLY A 411
ASN A 410
GLY A 451
 None
None
NAD  A 501 (-3.2A)
None
 0.75A 1zlqA-4zz7A:
undetectable		 1zlqA-4zz7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		3 / 3 TYR A 408
GLU A 382
ASN A 149
 None
NAD  A 501 (-3.0A)
NAD  A 501 (-3.1A)
 0.97A 2y7hC-4zz7A:
undetectable		 2y7hC-4zz7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 6 HIS A 461
PHE A 449
LEU A 456
LEU A 246
 None
NAD  A 501 (-4.5A)
None
NAD  A 501 (-3.5A)
 1.19A 3bgdA-4zz7A:
undetectable		 3bgdA-4zz7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 11 LEU A 118
ALA A  65
PHE A  69
MET A 161
TYR A 110
 None
 0.94A 3bszF-4zz7A:
undetectable		 3bszF-4zz7A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 11 LEU A  74
ALA A 191
LEU A 188
MET A 198
VAL A 108
 None
 1.13A 3e22B-4zz7A:
undetectable		 3e22B-4zz7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 11 LEU A  74
ALA A 191
LEU A 188
MET A 198
VAL A 108
 None
 1.10A 3e22D-4zz7A:
undetectable		 3e22D-4zz7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 1.01A 3erdA-4zz7A:
undetectable		 3erdA-4zz7A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 10 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 0.99A 3erdB-4zz7A:
undetectable		 3erdB-4zz7A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 0.98A 3hm1A-4zz7A:
undetectable		 3hm1A-4zz7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 GLU A 382
GLY A 385
VAL A 442
ASN A 149
PHE A 148
 NAD  A 501 (-3.0A)
None
None
NAD  A 501 (-3.1A)
NAD  A 501 (-4.1A)
 1.29A 3k13A-4zz7A:
undetectable		 3k13A-4zz7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 ILE A  46
ALA A  45
GLU A  43
ALA A  37
ALA A 210
 None
 0.94A 3mdvB-4zz7A:
undetectable		 3mdvB-4zz7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		3 / 3 PRO A 178
ASP A 177
GLU A 175
 None
None
NAD  A 501 (-2.8A)
 0.79A 3v4tC-4zz7A:
undetectable		 3v4tC-4zz7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 10 TYR A 110
VAL A 164
ALA A  65
GLY A 464
GLY A 113
 None
 1.11A 4mmdA-4zz7A:
undetectable		 4mmdA-4zz7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 TYR A 110
VAL A 164
ALA A  65
GLY A 464
GLY A 113
 None
 1.13A 4mmdB-4zz7A:
undetectable		 4mmdB-4zz7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 8 ASP A  96
SER A 276
ARG A 279
PRO A 322
 None
 1.22A 4uhxA-4zz7A:
undetectable		 4uhxA-4zz7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 8 ASP A  96
SER A 276
ARG A 279
PRO A 322
 None
 1.22A 4uhxA-4zz7A:
undetectable		 4uhxA-4zz7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 10 ALA A 286
ASP A 370
LEU A 368
LEU A 268
ALA A 264
 None
 1.12A 4zbrA-4zz7A:
undetectable		 4zbrA-4zz7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 6 ILE A  46
ALA A  45
THR A  41
ALA A  37
 None
 0.79A 4zf8A-4zz7A:
undetectable		 4zf8A-4zz7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 SER A 284
PHE A 148
PHE A 150
GLY A 411
MET A 433
 None
NAD  A 501 (-4.1A)
None
None
None
 1.47A 4zjlA-4zz7A:
undetectable		 4zjlA-4zz7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 1.00A 4zn7A-4zz7A:
undetectable		 4zn7A-4zz7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 11 MET A 198
ALA A 191
GLU A 190
LEU A  75
LEU A  74
 None
 1.04A 4zn7B-4zz7A:
undetectable		 4zn7B-4zz7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 4 ALA A 185
PRO A 178
LEU A  36
HIS A   6
 None
 1.41A 5eskA-4zz7A:
undetectable		 5eskA-4zz7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 9 LEU A  75
ILE A 163
LEU A 171
ALA A 191
MET A  68
 None
 0.99A 5og9A-4zz7A:
undetectable		 5og9A-4zz7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		5 / 12 VAL A 348
PHE A 320
LEU A 269
LEU A 308
VAL A 310
 None
 1.14A 5tudA-4zz7A:
undetectable		 5tudA-4zz7A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 8 THR A   3
HIS A   6
ASN A 202
PRO A 178
 None
 0.96A 5v4vB-4zz7A:
undetectable		 5v4vB-4zz7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 7 VAL A 393
VAL A 287
ILE A 403
ASP A 401
 None
 0.75A 5ywmX-4zz7A:
undetectable		 5ywmX-4zz7A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE
(Oceanimonas
doudoroffii) 		4 / 5 GLU A  89
VAL A  22
LEU A  34
HIS A   6
 None
 1.47A 6dyoA-4zz7A:
undetectable		 6dyoA-4zz7A:
10.28