SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 8 ASP A 214
TRP A 216
TYR A 291
THR A 211
 None
GLC  A 503 ( 3.9A)
GLC  A 502 ( 4.2A)
None
 1.00A 1ceaA-4zzeA:
undetectable
1ceaB-4zzeA:
undetectable		 1ceaA-4zzeA:
12.43
1ceaB-4zzeA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 GLY A 227
VAL A 230
ALA A 166
SER A 167
TYR A 396
 None
None
None
GLC  A 501 ( 4.6A)
None
 1.40A 1kiaD-4zzeA:
undetectable		 1kiaD-4zzeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		6 / 12 ILE A 106
LEU A 348
GLY A 159
PHE A 123
VAL A 327
ALA A 163
 None
 1.34A 1tlsA-4zzeA:
undetectable		 1tlsA-4zzeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 LEU A 348
GLY A 159
PHE A 123
VAL A 327
ALA A 163
 None
 1.29A 2kceA-4zzeA:
undetectable		 2kceA-4zzeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 9 ILE A 403
ILE A 397
PHE A 419
ALA A 226
LEU A 222
 None
 1.10A 2m9qA-4zzeA:
undetectable		 2m9qA-4zzeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 ALA A 312
THR A 228
ALA A 166
PHE A 307
MET A 196
 None
 1.21A 2nyrA-4zzeA:
undetectable		 2nyrA-4zzeA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 6 SER A 120
PHE A 123
ILE A 106
PHE A 108
 None
 1.15A 2qeiA-4zzeA:
undetectable		 2qeiA-4zzeA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 10 THR A 313
ILE A 320
LEU A 321
GLY A 168
THR A 228
 None
 1.03A 2wd9C-4zzeA:
undetectable		 2wd9C-4zzeA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 7 LEU A 197
PHE A 193
LEU A 259
PHE A 260
 None
 1.05A 3asoP-4zzeA:
undetectable
3asoW-4zzeA:
undetectable		 3asoP-4zzeA:
21.66
3asoW-4zzeA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 4 LEU A 354
ALA A 163
VAL A 327
PRO A 161
 None
 0.80A 3gv1B-4zzeA:
undetectable		 3gv1B-4zzeA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 7 PHE A 347
PHE A 344
PHE A  65
PHE A  54
 None
 1.16A 3ko0D-4zzeA:
undetectable
3ko0E-4zzeA:
undetectable		 3ko0D-4zzeA:
13.74
3ko0E-4zzeA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 5 PHE A  65
PHE A  54
PHE A 347
PHE A 344
 None
 1.24A 3ko0F-4zzeA:
undetectable
3ko0G-4zzeA:
undetectable		 3ko0F-4zzeA:
13.74
3ko0G-4zzeA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 5 PHE A 347
PHE A 344
PHE A  65
PHE A  54
 None
 1.15A 3ko0F-4zzeA:
undetectable
3ko0G-4zzeA:
undetectable		 3ko0F-4zzeA:
13.74
3ko0G-4zzeA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		3 / 3 LEU A 348
MET A 342
ASP A 104
 None
 0.92A 3v5wA-4zzeA:
undetectable		 3v5wA-4zzeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 6 LEU A 197
PHE A 193
LEU A 259
PHE A 260
 None
 1.05A 3wg7P-4zzeA:
undetectable
3wg7W-4zzeA:
undetectable		 3wg7P-4zzeA:
21.66
3wg7W-4zzeA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 5 THR A 228
LEU A 229
GLU A 251
LYS A 255
 None
 1.02A 4a3pA-4zzeA:
undetectable		 4a3pA-4zzeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 ASN A 417
ILE A 420
ILE A 248
THR A 250
THR A 243
 None
 1.05A 4k8cB-4zzeA:
undetectable		 4k8cB-4zzeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 ASN A 417
ILE A 420
ILE A 248
THR A 250
THR A 243
 None
 1.05A 4kanB-4zzeA:
undetectable		 4kanB-4zzeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 ASN A 417
ILE A 420
ILE A 248
THR A 250
THR A 243
 None
 1.04A 4kbeA-4zzeA:
undetectable		 4kbeA-4zzeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 ASN A 417
ILE A 420
ILE A 248
THR A 250
THR A 243
 None
 1.06A 4kbeB-4zzeA:
undetectable		 4kbeB-4zzeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 ASN A 417
ILE A 420
ILE A 248
THR A 250
THR A 243
 None
 1.06A 4lcaB-4zzeA:
undetectable		 4lcaB-4zzeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		3 / 3 LEU A 160
ILE A 345
ARG A 346
 None
 0.56A 4mk4B-4zzeA:
undetectable		 4mk4B-4zzeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		3 / 3 ASP A 104
HIS A 337
LYS A 338
 None
 0.95A 4qzuD-4zzeA:
undetectable		 4qzuD-4zzeA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		3 / 3 SER A 167
TYR A 291
ASP A 394
 GLC  A 501 ( 4.6A)
GLC  A 502 ( 4.2A)
GLC  A 501 ( 3.0A)
 0.89A 4rp8C-4zzeA:
undetectable		 4rp8C-4zzeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 PHE A 123
GLY A 332
ASP A  53
PHE A  55
ARG A  96
 None
 1.17A 4u95B-4zzeA:
undetectable		 4u95B-4zzeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		4 / 7 ASN A 172
TYR A 169
LEU A 377
PHE A 372
 None
 1.24A 4yv5A-4zzeA:
undetectable		 4yv5A-4zzeA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM
(Bifidobacterium
animalis) 		5 / 12 ALA A 312
LEU A 225
TYR A 171
PHE A 200
MET A 196
 None
 1.10A 5eshA-4zzeA:
1.3		 5eshA-4zzeA:
22.18